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Presbyophrenia: Clinical Aspects

Published online by Cambridge University Press:  29 January 2018

G. E. Berrios
G. E. Berrios*
Affiliation:
Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital (Level 4), Hills Road, Cambridge CB2 2QQ
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Summary

Fifteen cases meeting the diagnostic criteria for presbyophrenia are reported and compared with a control sample of patients suffering from dementia. The presbyophrenic patients exhibited more elevated mood, more hyperactivity, more disorientation, and had lower information scores than the controls. Traditional explanations of ‘presbyophrenic behaviour’ such as delirium, pathoplastic effect of personality, or superimposed cerebrovascular disease are not adequate. Instead, presbyophrenia may constitute a sub-type of dementia characterised by severe atrophy of the locus coeruleus, marked impairment of noradrenergic transmission, and uninhibited behaviour.

Type
Papers
Information
The British Journal of Psychiatry , Volume 147 , Issue 1 , July 1985 , pp. 76 - 79
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

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References

Ballinger, B. R., Reid, A. H. & Heather, B. B. (1982) Cluster analysis of symptoms in elderly demented patients. British Journal of Psychiatry, 140, 257–262.CrossRefGoogle ScholarPubMed
Berlyne, N. (1972) Confabulation. British Journal of Psychiatry, 120, 31–39.Google Scholar
Berrios, G. E. 1985 Presbyophrenia: The rise and fall of a concept. Psychological Medicine. In press.Google Scholar
Blessed, G., Tomlinson, B. E. & Roth, M. (1968) The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. British Journal of Psychiatry, 114, 797–811.Google Scholar
Bondareff, W., Mountjoy, C. Q. & Roth, M. (1982) Loss of Neurons of origin of the adrenergic projection of cerebral cortex (nucleus locus coeruleus) in senile dementia. Neurology, 32, 164–168.Google Scholar
Cross, A. J., Crow, T. J., Perry, E. K. et al (1981) Reduced dopamine-B-hydroxylase activity in Alzheimer's disease. British Medical Journal, 282, 93–94.Google Scholar
Crow, T. J., Deakin, J. F. W., File, S. G. et al (1978) The locus coeruleus noradrenergic system—evidence against a role in attention, habituation, anxiety and motor activity. Brain Research, 155, 249–261.Google Scholar
Devaux, A. & Log re, J. B. (1911) Amnesie et fabulation. Étude du syndrome ‘presbyophrenique’. Nouvelle Iconographie de la Salpetriere, 24, 90–115.Google Scholar
Goldstein, G. W. & Betz, A. L. (1983) Recent advances in understanding brain capillary function. Annals of Neurology, 14, 393–395.Google Scholar
Harik, S. I. & McGuginal, T. (1984) The protective influence of the locus coeruleus on the Blood-Brain Barrier. Annals of Neurology, 15, 568–574.Google Scholar
Lerner, P., Goodwin, F. K. & van Kammen, D. P. et al (1978) Dopamine-B-Hydroxylase in the cerebro-spinal fluid of psychiatric patients. Biological Psychiatry, 13, 685–694.Google Scholar
Lipowsh, Z. J. (1983) Transient cognitive disorders (delirium, acute confusional states) in the elderly. American Journal of Psychiatry, 140, 1426–1436.Google Scholar
Mann, D. M. A., Lincoln, J., Yates, P. O. et al (1980) Changes in monoamine containing neurons of the human CNS in senile dementia. British Journal of Psychiatry, 136, 533–541.Google Scholar
Mann, D. M. A., Yates, P. O. & Hawkes, J. S. (1982) The noradrenergic system in Alzheimer's and multiinfarct dementias. Journal of Neurology, Neurosurgery and Psychiatry, 45, 113–119.Google Scholar
Mann, D. M. A., Yates, P. L. & Hawkes, J. (1983) Pathology of the human locus coeruleus. Clinical Neuropathology, 2, 1–7.Google Scholar
McEntee, W. J. & Mair, R. G. (1978) Memory impairment in Korsakoff's psychosis: a correlation with brain noradrenergic activity. Science, 202, 905–907.Google Scholar
McEntee, W. J. & Mair, R. G. (1980) memory enhancement in Korsakoff's psychosis by clonidine: further evidence of a noradrenergic deficit. Annals of Neurology, 7, 406–470.Google Scholar
Mercer, B., Wapner, W., Gardner, H. & Benson, F. (1977) A study of confabulation. Archives of Neurology, 34, 429–433.Google Scholar
Sack, R. L. & Goodwin, F. K. (1974) inhibition of dopamine-B-hydroxylase in manic patients: a clinical trial with fusaric acid. Archives of General Psychiatry, 31, 649.Google Scholar
Wertheimer, J. (1974) La démence sénile et son évolution. Revue Medicale Suisse Romande, 94, 545–554.Google ScholarPubMed
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