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Prenatal Exposure to Influenza Does Not Cause Schizophrenia

Published online by Cambridge University Press:  02 January 2018

T. J. Crow  and
D. J. Done
T. J. Crow*
Affiliation:
Division of Psychiatry, Clinical Research Centre, Northwick Park Hospital, Harrow HA1 3UJ
D. J. Done
Affiliation:
Department of Psychology, Hatfield Polytechnic, College Lane, Hatfield, Herts AL10 9AB
*
∗Correspondence
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Abstract

Claims have been made that maternal infection with influenza during pregnancy is a cause of schizophrenia in the child. These assertions are based upon some apparently significant associations between the timing of influenza epidemics in the general population and birth rates of people who later suffered from schizophrenia. Such associations have not been present in studies of the 1919 and 1957 epidemics, with sample sizes larger than those on which the claims were made. More decisively, in an investigation of the subsequent psychiatric admissions of people born a few months after the 1957 epidemic, it was found that the children of 945 mothers who actually suffered from influenza during the second trimester of pregnancy were at no greater risk of developing schizophrenia than children of mothers who were not infected. In contrast to the predictions of the influenza hypothesis of 26.5 extra cases by broad diagnostic criteria and 15.8 cases by narrow criteria, the numbers observed in children of mothers exposed to influenza in the second trimester were 3 and 1 cases respectively, close to the expected rate. It is concluded that prenatal influenza and schizophrenia are unrelated.

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Information
The British Journal of Psychiatry , Volume 161 , Issue 3 , September 1992 , pp. 390 - 393
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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References

Barr, C. E., Mednick, S. A. & Munk-Jorgenson, P. (1990) Exposure to influenza epidemic during gestation and adult schizophrenia. Archives of General Psychiatry, 47, 869–874.Google Scholar
Crow, T. J. (1983) Is schizophrenia an infectious disease? Lancet, i, 173–175.Google Scholar
Crow, T. J. & Done, D. J. (1986) Age of onset of schizophrenia in siblings: a test of the contagion hypothesis. Psychiatry Research, 18, 107–117.Google Scholar
Crow, T. J., Done, D. J. & Johnstone, E. C. (1991) Schizophrenia and influenza. Lancet, 338, 116–117.Google Scholar
Done, D. J., Johnstone, E. C., Frith, C. D., et al (1991) Complications of pregnancy and delivery in relation to psychosis in adult life: a study using the British perinatal mortality survey. British Medical Journal, 302, 1576–1580.Google Scholar
Goodall, E. (1932) The exciting cause of certain states, at present classified under schizophrenia by psychiatrists, may be infection. Journal of Mental Science, 78, 746–755.Google Scholar
Hare, E. H. (1983) Was insanity on the increase? British Journal of Psychiatry, 142, 439–455.Google Scholar
Jablensky, A. (1988) Epidemiology of schizophrenia. In Schizophrenia: The Major Issues (eds Bebbington, P. & McGuffin, P.), pp. 19–35. London: Heinemann.Google Scholar
Jablensky, A., Sartorius, N., Ernberg, G., et at (1992) Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten country study. Psychological Medicine (suppl. 20).Google Scholar
Kendell, R. E. & Kemp, I. W. (1989) Maternal influenza in the etiology of schizophrenia. Archives of General Psychiatry, 46, 878–882.Google Scholar
Mednick, S. A., Machon, R. A., Huttunen, M. O., et al (1988) Adult schizophrenia following prenatal exposure to an influenza epidemic. Archives of General Psychiatry, 45, 189–192.Google Scholar
Menninger, K. A. (1926) Influenza and schizophrenia: an analysis of post-influenzal “dementia praecox” as of 1918 and five years later. American Journal of Psychiatry, 5, 469–529.Google Scholar
Menninger, K. A. (1928) The schizophrenic syndrome as the product of acute infectious disease. Archives of Neurology and Psychiatry, 20, 464–481.Google Scholar
O'Callaghan, E., Sham, P., Takei, N., et al (1991) Schizophrenia after prenatal exposure to the 1957 A2 influenza epidemic. Lancet, 337, 1248–1250.Google Scholar
Payne, A. N. M. (1958) Symposium on the Asian influenza epidemic 1957. Proceedings of the Royal Society of Medicine, 51, 1009–1018.Google Scholar
Shepherd, P. M. (1985) The National Child Development Study: An Introduction to the Background to the Study and Methods of Data Collection. London: Social Statistics Research Unit, City University.Google Scholar
Torrey, E. F. & Peterson, M. R. (1973) Slow and latent viruses in schizophrenia. Lancet, 2, 22–24.Google ScholarPubMed
Torrey, E. F., Bowler, A. E. & Rawlings, R. (1991) An influenza epidemic and the seasonality of schizophrenic births. In Psychiatry and Biological Factors (ed. Kurstat, E.), pp. 109–116. New York: Plenum.Google Scholar
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