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Pre-morbid Psychopathology in Schizophrenia Spectrum

Published online by Cambridge University Press:  02 January 2018

Josef Parnas*
Affiliation:
University Department of Psychiatry, Kommunehospitalet, and Psykologisk Institut, Kommunehospitalet, Copenhagen, Denmark
Aage Jørgensen
Affiliation:
University Department of Psychiatry, Kommunehospitalet, Copenhagen, Denmark
*
Correspondence

Abstract

In a prospective, longitudinal study of high-risk offspring of schizophrenic mothers, of several dimensions of pre-morbid behaviour ‘peculiarity’ predicted subsequent schizophrenia or schizotypy. Peculiarity/eccentricity may represent a subtle marker of the schizophrenic genotype. ‘Pre-schizophrenics', as compared with ‘pre-schizotypes', were characterised by affective dyscontrol, reflected in less introverted and more disturbed behaviour.

Type
Papers
Copyright
Copyright © Royal College of Psychiatrists, 1989 

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References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.Google Scholar
Bilder, R. M., Mukherjee, S., Rieder, R. O., et al (1985) Symptomatic and neuropsychologic components of defect states. Schizophrenia Bulletin, 11, 409419.Google Scholar
Bleuler, E. (1950) Dementia Praecox or the Group of Schizophrenias. New York: International University Press.Google Scholar
Cannon, T., Mednick, S. A. & Parnas, J. (1989) Two pathways to schizophrenia in children at risk. In Straight and Devious Pathways from Childhood to Adulthood (eds L. Robins & M. Rutter). Cambridge: Cambridge University Press (in press).Google Scholar
Cronbach, L. J. (1951) Coefficient alpha and internal structure of tests. Psychometrica, 16, 297334.CrossRefGoogle Scholar
Endicott, J. & Spitzer, R. L. (1972) Current and past psychopathology scales (CAPPS). Archives of General Psychiatry, 27, 678687.Google Scholar
Fleiss, J. L., William, J. B. W. & Dubro, A. F. (1986) The logistic regression analysis of psychiatric data. Journal of Psychiatric Research, 20, 195209.CrossRefGoogle ScholarPubMed
Gibbons, R. D., Lewine, R. R. J., Davis, J. M., et al (1985) An empirical test of a Kraepelinian vs. a Bleulerian view of negative symptoms. Schizophrenia Bulletin, 11, 390396.CrossRefGoogle Scholar
Gottesman, E. E. & Shields, J. S. (1972) Schizophrenia and Genetics: A Twin Study Vantage Point. New York: Academic Press.Google Scholar
Gunderson, J. G., Siever, L. J. & Spaulding, E. (1983) The search for a schizotype. Archives of General Psychiatry, 40, 1522.Google Scholar
Inouye, E. (1970) Personality deviations seen in monozygotic co-twins of the index cases with classical schizophrenia. Acta Psychiatrica Scandinavica (suppl. 219), 9096.Google Scholar
Jaspers, K. (1963) General Psychopathology. Chicage: University of Chicago Press.Google Scholar
Jørgensen, A., Teasdale, T. W., Parnas, J., et al (1987) The Copenhagen high risk project. The diagnosis of maternal schizophrenia and its relation to offspring diagnosis. British Journal of Psychiatry, 151, 753757.CrossRefGoogle Scholar
Jung, C. G. (1960) Uber die Psychologie der Dementia Praecox: Ein Versucht. In The Psychology of Dementia Praecox (trans. Hull, R. F. C.), Bollinger Series. Princeton: Princeton University Press.Google Scholar
Kety, S. S., Rosenthal, D., Wender, P. H., et al (1978) The biological and adoptive families of adopted individuals who later became schizophrenic: prevalence of mental illness and other characteristics. In The Nature of Schizophrenia (eds L. C. Wynne, R. L. Cromwell & S. Matthysse), pp. 2537. New York: Wiley.Google Scholar
Kraepelin, E. (1971) Dementia Praecox and Paraphrenia. New York: Robert E. Krieger Publishing Corporation.Google Scholar
Kretschmer, E. (1925) Physique and Character. London: Kegan Paul.Google Scholar
Mednik, S. A. & Schulsinger, F. (1965) A Longitudinal Study of Children with a High Risk for Schizophrenia: a preliminary report, pp. 255296. New York: Academic Press.Google Scholar
Minkowski, E. (1927) La Schizophrenic Paris: Payot.Google Scholar
Parnas, J., Schulsinger, F., Schulsinger, H., et al (1982a) Behavioural precursors of the schizophrenia spectrum. Archives of General Psychiatry, 39, 658664.Google Scholar
Parnas, J., Schulsinger, F., Teasdale, T. W., et al (1982b) Perinatal complications and clinical outcome within the schizophrenia spectrum. British Journal of Psychiatry, 140, 416420.Google Scholar
Parnas, J., Teasdale, T. W. & Schulsinger, H. (1985) Institutional rearing and diagnostic outcome in children of schizophrenic mothers: a prospective high risk study. Archives of General Psychiatry, 42, 762769.Google Scholar
Parnas, J., Jørgensen, A., Teasdale, T. W., et al (1988) Temporal course of symptoms and social functioning in relapsing schizophrenics: a six year follow up. Comprehensive Psychiatry, 29, 361371.Google Scholar
Ruemke, H. C. (1942) Das Kernsymptom der Schizophrenic und das “Praecox Gefuhl”. Zentralblatt Gesamte Neurologie Psychiatric, 102, 168169.Google Scholar
Schulsinger, F., Parnas, J., Petersen, T. E., et al (1984) Cerebral ventricular size in offspring of schizophrenic mothers: a preliminary study. Archives of General Psychiatry, 41, 602606.Google Scholar
Schulsinger, H. (1976) A ten year follow up of schizophrenic mothers. Clinical assessment. Acta Psychiatrica Scandinavica, 53, 371386.CrossRefGoogle Scholar
Schulsinger, H. & Parnas, J. (1988) Temporal stability of schizotypal disorders. In Proceedings of First International Congress on Personality Disorders, 1988. Copenhagen: Munksgaard.Google Scholar
Sommers, A. A. (1985) “Negative symptoms”: conceptual and methodological problems. Schizophrenia Bulletin, 11, 364379.CrossRefGoogle ScholarPubMed
Stransky, E. (1903) Zur Kenntnis gewisser erworbener Bloedsinnsformen. Neurologisches Zentralblatt, 24, 1149.Google Scholar
Stransky, E. (1904) Zur Auffassung gewisser Symptome der Dementia Praecox. Neurologisches Zentralblatt, 24, 1074–1065, 1137–1143.Google Scholar
Torgersen, S. (1985) Relationship of schizotypal personality disorder to schizophrenia: genetics. Schizophrenia Bulletin, 11, 554563.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Syndromes. London: Cambridge University Press.Google Scholar
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