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Premenstrual Syndrome

A Double-blind Cross-over Study of Treatment with Dydrogesterone and Placebo

Published online by Cambridge University Press:  02 January 2018

Gwyneth A. Sampson ,
Patricia R. M. Heathcote ,
Jennifer Wordsworth ,
Philip Prescott  and
Alan Hodgson
Gwyneth A. Sampson*
Affiliation:
Whiteley Wood Clinic
Patricia R. M. Heathcote
Affiliation:
Sheffield Health Authority
Jennifer Wordsworth
Affiliation:
Family Planning Association, Sheffield
Philip Prescott
Affiliation:
University of Southampton
Alan Hodgson
Affiliation:
Duphar Laboratories, Southampton
*
∗Whiteley Wood Clinic, Woofindin Road, Sheffield S10 3TL
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Abstract

A double-blind, cross-over, placebo-controlled study of dydrogesterone (10 mg b.d.) in the treatment of premenstrual syndrome is described. Two groups of women were studied: secondarily referred hospital clinic patients, and self-referred patients. Only one-third of patients screened completed the study. All patients showed significant improvements in symptom scores during the course of the study, the only significant difference between placebo- and dydrogesterone-treated patients being an increase in frequency of breast tenderness and a decrease in pain with menstrual bleeding in the latter.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 153 , Issue 2 , August 1988 , pp. 232 - 235
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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