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Prediction of Outcome in Senile Dementia—A Computed Tomography Study

Published online by Cambridge University Press:  29 January 2018

Mohsen Naguib  and
Raymond Levy
Mohsen Naguib
Affiliation:
The Bethlem Royal and Maudsley Hospitals and the Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 6AF
Raymond Levy
Affiliation:
The Bethlem Royal and Maudsley Hospitals and the Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 6AF
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Summary

Forty patients suffering from senile dementia who had been subjected to detailed clinical and psychological assessment and computed tomography (CT) were followed up for a mean period of 28.78 months. All but one were traced. The deceased (27) were compared with the survivors (12). All males had died at follow-up. The mean age was not statistically significant but the survivors differed significantly from the deceased in having performed better on a number of clinical and psychological tests, particularly those involving speech functions and constructoinal ability. Measures of ventricular size and cortical atrophy were not of predictive value, but a new technique of measuring radiological density showed that this was significantly lower in the right parietal region in the original CT scans of those who subsequently died. The study confirms that clinical involvement of the parietal lobes is an indication of poor prognosis and reports the first radiological support for this view. It also suggests that a more directly quantitative approach to computed tomography may yield results which are more useful than those obtained from visual reconstructions.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 140 , Issue 3 , March 1982 , pp. 263 - 267
Copyright
Copyright © Royal College of Psychiatrists, 1982 

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