Hostname: page-component-848d4c4894-nmvwc Total loading time: 0 Render date: 2024-07-05T12:40:20.316Z Has data issue: false hasContentIssue false
  • English
  • Français

Prediction in Drug Abuse: Cocaine Interactions with Alcohol and Buprenorphine

Published online by Cambridge University Press:  06 August 2018

P. Mannelli ,
L. Janiri ,
E. Tempesta  and
R. T. Jones
P. Mannelli*
Affiliation:
Drug and Alcohol Dependence Unit, Department of Psychiatry, Catholic University, Rome, Italy
L. Janiri
Affiliation:
Drug and Alcohol Dependence Unit, Department of Psychiatry, Catholic University, Rome, Italy
E. Tempesta
Affiliation:
Drug and Alcohol Dependence Unit, Department of Psychiatry, Catholic University, Rome, Italy
R. T. Jones
Affiliation:
Drug Dependence Laboratory, Langley Porter Psychiatric Institute, University of California
*
∗Correspondence
Get access Rights & Permissions [Opens in a new window]

Abstract

We describe the limitations on studying the interactions of drugs of abuse in humans. Two ‘acute’ studies were carried out. In the first study, the administration of alcohol/placebo with cocaine showed the possibility of identifying the euphoric effect of the drugs by the EEG power spectra analysis in terms of enhancement of alpha- and beta-wave activity. The results of the second study, in which cocaine and buprenorphine were administered, show the existence of low-dose interactions and the influence of buprenorphine on craving for cocaine.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 163 , Issue S21: Prediction in Psychopharmacology , September 1993 , pp. 39 - 45
Copyright
Copyright © 1993 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adams, E. H., Gfroerer, J. C. & Rouse, B. A. (1989) Epidemiology of substance abuse including alcohol and cigarette smoking. Annals of the New York Academy of Sciences, 562, 14–20.CrossRefGoogle ScholarPubMed
Adler, M. W. (1986) Critical factors in studying drug interactions. National Institute on Drug Abuse (NIDA) Research Monograph Series, 68, 6–14.Google Scholar
Balster, R. L. (1988) Pharmacological effects of cocaine relevant to its abuse. NIDA Research Monograph Series, 30, 1–13.Google Scholar
Begleiter, H. & Platz, A. (1972) The effects of alcohol on the central nervous system in humans. In The Biology of Alcoholism, Vol. 2 (eds B. Kiss & H. Begleiter). Plenum Press.Google Scholar
Berger, H. (1931) Archives of Psychiatry Nervenkr, 94, 16–30 (trans. in Electroencephalography and Clinical Neurophysiology (1969), suppl. 28, 95-132).Google Scholar
Berger, H. (1937) Archives of Psychiatry Nervenkr, 106, 577–584 (trans, in Electroencephalography and Clinical Neurophysiology (1969), suppl. 28, 291-297).Google Scholar
Braude, M. C. & Ginzburg, H. M. (1986) Introduction and overview. NIDA Research Monograph Series, 68, 1–5.Google Scholar
Brown, B. B. (1970) Recognition of aspects of consciousness through association with EEG alpha activity represented by a light signal. Psychophysiology, 6, 442–452.Google Scholar
Brown, E. E., Finlay, J. M., Wong, J. T., et al (1991) Behavioral and neurochemical interactions between cocaine and buprenorphine: implications for the pharmacotherapy of cocaine abuse. Journal of Pharmacology and Experimental Therapy, 256, 119–126.Google Scholar
Coppola, R. & Herrmann, W. M. (1987) Psychotropic drug profiles: comparison by topographic maps of absolute power. Neuropsychobiology, 18, 97–104.Google Scholar
Cornelius, J. R., Schulz, S. C., Brenner, R. F., et al (1988) Changes in EEG mean frequency associated with anxiety and with amphetamine challenge in BP. Biological Psychiatry, 24, 587–594 Google Scholar
Davis, P. A., Gibbs, F. A., Davis, H., et al (1941) The effects of alcohol upon the electroencephalogram (brain waves). Quarterly Journal of Studies on Alcohol, 1, 626–637.Google Scholar
de Wit, H. & Stewart, J. (1981) Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology, 75, 134–143.Google Scholar
Farre, M., Llorente, M., Ugena, B., et al (1990) Interaction of cocaine with ethanol: a pilot study in humans (Abstr.). In Abstracts, 1990. Richmond, VA: Committee on Problems of Drug Dependence.Google Scholar
Fruhstorfer, H., Linblom, U. & Schmidt, W. G. (1976) Method for quantitative estimation of thermal thresholds in patients. Journal of Neurology, Neurosurgery and Psychiatry, 39, 1071–1075.CrossRefGoogle ScholarPubMed
Fudala, P. J., Jaffe, J. H., Dax, E. M., et al (1990) Use of buprenorphine in the treatment of opioid addiction. 2. Physiologic and behavioral effects of daily and alternate-day administration and abrupt withdrawal. Clinical Pharmacology and Therapeutics, 47, 525–534.Google Scholar
Fudala, P. J., Johnson, R. E. & Jaffe, J. H. (1991) Outpatient comparison of buprenorphine and methadone maintenance. II. Effects on cocaine usage, retention time in study and missed clinic visits. NIDA Research Monograph Series, 105, 587–588.Google Scholar
Gerber, G. J. & Stretch, R. (1975) Drug-induced reinstatement of extinguished self-administration behavior in monkeys. Pharmacology, Biochemistry and Behavior, 3, 1055–1061.Google Scholar
Grant, B. F. & Harford, T. C. (1990) Concurrent and simultaneous use of alcohol with cocaine: results of national survey. Drug and Alcohol Dependence, 25, 97–104.Google Scholar
Hammersley, R., Lavelle, T. & Forsyth, A. (1990) Buprenorphine and temazepam abuse. British Journal of Addiction, 85, 301–303.Google Scholar
Hearn, W. L., Flynn, D. D., Hime, G. W., et al (1991) Cocaethylene: a unique cocaine metabolite displays high affinity for the dopamine transporter. Journal of Neurochemistry, 56, 698–701.Google Scholar
Herning, R. I., Jones, R. T., Hooker, W. D., et al (1985) Cocaine increases EEG beta: a replication and extension of Hans Berger's historical experiments. Electroencephalography and Clinical Neurophysiology, 60, 470–477.Google Scholar
Hubbard, R. L., Bray, R. M., Craddock, S. G., et al (1986) Issues in the assessment of multiple drug use among drug treatment clinics. NIDA Research Monograph Series, 68, 15–40.Google Scholar
Jaffe, J. H., Cascella, N. G., Kumor, K. M., et al (1989) Cocaine-induced cocaine craving. Psychopharmacology, 97, 59–64.Google Scholar
Jasinski, D. R., Pevnick, J. S. & Griffith, J. D. (1978) Human pharmacology and abuse potential of the analgesic buprenorphine. Archives of General Psychiatry, 35, 501–516.CrossRefGoogle ScholarPubMed
Jasper, H. H. (1958) The ten-twenty electrode system of the international federation. Electroencephalography and Clinical Neurophysiology, 10, 371–375.Google Scholar
Johanson, C. E. (1988) Behavioral studies of the reinforcing properties of cocaine. NIDA Research Monograph Series, 88, 107–124.Google Scholar
Kahn, E. M., Weiner, R. D., Brenner, R. P., et al (1988) Topographic maps of brain electrical activity - pitfalls and precautions. Biological Psychiatry, 23, 628–636.Google Scholar
Kamien, J. B., Mello, N. K., Mendelson, J. H., et al (1991) Buprenorphine suppresses cocaine self-administration by rhesus monkeys over 1 to 4 months of daily treatment. NIDA Research Monograph Series, 105, 619–620.Google Scholar
Kaul, B. & Davidow, B. (1981) Drug abuse patterns of patients on methadone maintenance treatment in New York City. American Journal of Drug and Alcohol Abuse, 8, 17–25.Google Scholar
Koob, G. F. & Bloom, F. E. (1988) Cellular and molecular mechanisms of drug dependence. Science, 242, 715–723.Google Scholar
Kosten, T. R., Rounsaville, B. J. & Kleber, H. D. (1987) A 2.5 year follow-up of cocaine use among treated opioid addicts. Have our treatments helped? Archives of General Psychiatry, 44, 281–284.CrossRefGoogle ScholarPubMed
Kosten, T. R., Kleber, H. D. & Morgan, C. (1989) Role of opioid antagonists in treatment intravenous cocaine abuse. Life Sciences, 44, 887–892.Google Scholar
Kosten, T. A., Marby, D. W. & Nestler, E. J. (1991) Cocaine conditioned place preference is attenuated by chronic buprenorphine treatment. Life Sciences, 49, 201–206.Google Scholar
Lin, Y., Monrow, T. J., Kiritsy-Roy, J. A., et al (1989) Cocaine: evidence for supraspinal, dopamine-mediated, non-opiate analgesia. Brain Research, 479, 306–312.Google Scholar
Lindenbaum, G. A., Carrol, S. F., Daskal, I., et al (1989) Patterns of alcohol and drug abuse in an urban trauma center: the increasing role of cocaine abuse. Journal of Trauma, 29, 165.Google Scholar
Lukas, S. E. (1991) Topographic brain mapping during cocaine-induced intoxication and self-administration. Biological Psychiatry, 2, 25–29.Google Scholar
Lukas, S. E., Mendelson, J. H. & Benedikt, R. A. (1986) Instrumental analysis of ethanol-induced intoxication in human males. Psychopharmacology, 89, 8–13.Google Scholar
Lukas, S. E., Mendelson, J. H. & Benedikt, R. A. (1988) Electroencephalographic activity and plasma ACTH during ethanol-induced euphoria. Biological Psychiatry, 23, 141–148.Google Scholar
Lukas, S. E., Mendelson, J. H., Woods, B. T., et al (1989) Topographic distribution of EEG alpha activity during ethanol-induced intoxication of women. Journal of Studies on Alcohol, 50, 176–185.Google Scholar
Lukas, S. E., Mendelson, J. H., Amass, L., et al (1990) Problems of drug dependence. NIDA Research Monograph Series, 95, 146–151.Google Scholar
Malmo, R. B. (1959) Activation: a neuropsychological dimension. Psychology Review, 66, 367–386.Google Scholar
Matejcek, M. (1982) Vigilance and the EEG: psychological, physiological and pharmacological aspects. In EEG and Drug Research (ed. Hermann, W. M.). Stuttgart: Gustav Fischer.Google Scholar
Mello, N. K. (1991) Preclinical evaluation of the effects of buprenorphine, naltrexone and desipramine on cocaine self-administration. NIDA Research Monograph Series, 105, 189–195.Google Scholar
Misra, A. L., Pontani, R. B. & Vadlamani, N. L. (1987) Stereospecific potentiation of opiate analgesia by cocaine: predominant role of noradrenaline. Pain, 28, 129–138.Google Scholar
O'Connor, J. J., Moloney, E., Travers, R., et al (1988) Buprenorphine abuse among opiate addicts. British Journal of Addiction, 83, 1085–1087.CrossRefGoogle ScholarPubMed
Pockberger, H., Rappelsberger, P., Petsche, H., et al (1984) Computer assisted EEG topography as a tool in the evaluation of actions of psychoactive drugs in patients. Neuropsychobiology, 12, 183–187.Google Scholar
Rosen, M. I. & Kosten, T. R. (1991) Buprenorphine: beyond methadone? Hospital and Community Psychiatry, 42, 347–349.Google Scholar
Shimada, A., Tsuda, T. & Yanagita, T. (1988) Mode of potentiating action of cocaine in morphine analgesia. Japanese Journal of Pharmacology, 48, 185–193.Google Scholar
Strang, J. (1985) Abuse of buprenorphine. Lancet, ii, 725.Google Scholar
Tallarida, R. J. & Murray, R. B. (1981) Manual of Pharmacologic Calculations. New York: Springer Verlag.Google Scholar
Varga, B. & Nagy, T. (1960) Analysis of alpha-rhythm in the electroencephalogram of alcoholics. Electroencephalography and Clinical Neurophysiology, 12, 933.Google Scholar
Winger, G. (1988) Pharmacological modifications of cocaine and opioid self administration. NIDA Research Monograph Series, 88, 125–137.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.