Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-31T15:08:31.606Z Has data issue: false hasContentIssue false
  • English
  • Français

Platelet Monoamine Oxidase Activity and 5-Hydroxytryptamine Uptake in Agoraphobic Patients

Published online by Cambridge University Press:  02 January 2018

J. Flaskos ,
N. Theophilopoulos  and
A. J. George
J. Flaskos
Affiliation:
Pharmacology Department, School of Pharmacy, Liverpool Polytechnic and University Department of Psychiatry, Liverpool University
N. Theophilopoulos
Affiliation:
Pharmacology Department, School of Pharmacy, Liverpool Polytechnic and University Department of Psychiatry, Liverpool University
A. J. George*
Affiliation:
University Department of Psychiatry, Liverpool University; Department of Psychiatry, Tameside General Hospital
*
∗Liverpool Polytechnic, Byron Street, Liverpool L3 3AF
Get access Rights & Permissions [Opens in a new window]

Abstract

Platelet MAO activity and platelet serotonin uptake were determined in 20 agoraphobic and 16 neurotic depressive out-patients, and 19 healthy volunteers. Agoraphobic patients were characterised by significantly higher mean values of platelet MAO activity compared with the other two groups, while neurotic depressive patients exhibited significantly higher maximum platelet serotonin uptake velocity. These findings are compatible with an abnormality in the uptake and metabolism of serotonin.

Type
Papers
Information
The British Journal of Psychiatry , Volume 155 , Issue 5 , November 1989 , pp. 680 - 685
Copyright
Copyright © Royal College of Psychiatrists, 1989 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Agras, W. S., Chapin, N. & Oliveau, D. C. (1972) The natural history of phobia: course and prognosis. Archives of General Psychiatry, 26, 315–317.Google Scholar
Alexander, N., Velazquez, M. T., Decur, M., et al (1980) Indices of sympathetic activity in the sinoaortic-denervated hypertensive rat. American Journal of Physiology, 238, H521–H526.Google Scholar
American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders, 3rd edn. Washington DC: APA.Google Scholar
Balon, R., Pohl, R., Yeragani, V., et al (1987a) Platelet serotonin levels in panic disorder. Acta Psychiatrica Scandinavica, 75, 315–317.Google Scholar
Balon, R., Rainey, J. M., Pohl, R., et al (1987b) Platelet monoamine oxidase activity in panic disorder. Psychiatry Research, 22, 37–41.Google Scholar
Baron, M., Levitt, M. & Perman, R. (1980) Human platelet monoamine oxidase and the menstrual cycle. Psychiatry Research, 3, 323–327.Google Scholar
Bhagat, B., Bryan, R. J. & Lee, Y. C. (1973) Increase in adrenal monoamine oxidase activity in hypophysectomized rats after ACTH. Neuropharmacology, 12, 1199–1202.Google Scholar
Braestrup, C. & Nielsen, M. (1982) Anxiety. Lancet, ii, 1030–1034.Google Scholar
Charney, D. S. & Heninger, M. D. (1986) Serotonin function in panic disorders. Archives of General Psychiatry, 43, 1059–1065.Google Scholar
Codd, E. E. & Walker, R. F. (1987) Platelet serotonin uptake: methods and strain differences. Psychiatry Research, 22, 61–67.Google Scholar
Coper, H., Fahndrich, E., Genert, A., et al (1979) Depression and monoamine oxidase. Progress in Neuro-Psychopharmacology, 3, 441–463.Google Scholar
Davidson, J. R. T., McLeod, M. N., Turnbull, C. D., et al (1980) Platelet monoamine oxidase activity and the classification of depression. Archives of General Psychiatry, 37, 771–773.Google Scholar
Eysenck, H. J. & Eysenck, S. B. G. (1964) Manual of the Eysenck Personality Inventory. London: London University Press.Google Scholar
File, S. F. (1984) The neurochemistry of anxiety. In Anti-Anxiety Agents (eds G. D. Burrows, T. R. Norman & B. Davies), pp. 13–24. Amsterdam: Elsevier.Google Scholar
Flaskos, J. & George, A. (1981) The effect of flupenthixol isomers on 3H-5HT uptake into blood platelets. British Journal of Pharmacology, 73, 249–250.Google Scholar
Flaskos, J., George, A. J. & Theophilopoulos, N. (1984) Symptoms of agoraphobia in relation to monoamine oxidase activity. Clinical Neuropharmacology, 7, 180–182.Google Scholar
Fowler, C. J., Wiberg, Å., Oreland, L., et al (1981) Monoamine oxidase activity and kinetic properties in platelet rich plasma from controls, chronic alcoholics and patients with non-alcoholic liver disease. Biochemical Medicine, 25, 356–365.Google Scholar
Gawel, M., Glover, V., Park, D., et al (1977) The effect of exercise upon platelet MAO-B activity. Clinical Science and Molecular Medicine, 52, 32.Google Scholar
Gentil, V., McCurdy, R. L., Alevizos, B., et al (1976) The effects of adrenaline injections on human platelet monoamine oxidase and related measures. Psychopharmacology, 50, 187–192.Google Scholar
George, A. & Jones, G. T. (1976) Studies on monoamine oxidase in rat spinal cords. British Journal of Pharmacology, 58, 270–271.Google Scholar
Glover, V., Sandler, M., Hughes, A., et al (1980) Platelet monoamine oxidase activity in megaloblastic anaemia. Journal of Clinical Pathology, 33, 963–965.CrossRefGoogle ScholarPubMed
Gordon, J. L. & Olverman, H. J. (1978) 5-Hydroxytryptamine and dopamine transport by rat and human blood platelets. British Journal of Pharmacology, 62, 219–226.Google Scholar
Gorman, J., Liebowitz, M. R., Fyer, A. J., et al (1985) Platelet monoamine oxidase activity in patients with panic disorder. Biological Psychiatry, 20, 852–857.Google Scholar
Gudeman, J. E., Schatzberg, A. F., Samson, J. A., et al (1982) Toward a biochemical classification of depressive disorders: II Platelet MAO activity and clinical symptoms in depressed patients. American Journal of Psychiatry, 139, 630–633.Google Scholar
Hallstrom, C. O. S., Pare, C. M. B., Rees, W. L., et al (1976) Platelet uptake of 5-hydroxytryptamine and dopamine in depression. Postgraduate Medical Journal (Suppl.), 52, 40–44.Google ScholarPubMed
Innis, R. B., Charney, D. S. & Heninger, G. R. (1987) Differential 3H-imipramine platelet binding in patients with panic disorder and depression. Psychiatry Research, 21, 33–41.Google Scholar
Khan, A., Lee, E., Dager, S., et al (1986) Platelet MAO-B activity in anxiety and depression. Biological Psychiatry, 21, 847–849.Google Scholar
Kralik, P. M., Ho, B. T., Mathew, R. J., et al (1983) Kinetic evaluation of platelet monoamine oxidase following relaxation in chronic anxiety. Acta Psychiatrica Scandinavica, 67, 307–314.Google Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L., et al (1951) Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265–275.Google Scholar
Mann, J. (1979) Altered platelet monoamine oxidase activity in affective disorders. Psychological Medicine, 9, 729–736.Google Scholar
Marks, I. M. & Mathews, A. M. (1979) Brief standard self-rating for phobic patients. Behaviour Research and Therapy, 17, 263–267.CrossRefGoogle ScholarPubMed
Mathew, R. J., Ho, B. T., Kralik, P., et al (1981) Anxiety and platelet MAO levels after relaxation training. American Journal of Psychiatry, 138, 371–373.Google Scholar
Maura, G., Versace, P. & Paudice, P. (1978) Chronic environmental stress on the development of MAO and COMT in discrete brain regions. Pharmacological Research Communications, 10, 235–241.Google Scholar
Meltzer, H. Y., Arora, R. C., Babar, R., et al (1981) Serotonin uptake in blood platelets of psychiatric patients. Archives of General Psychiatry, 38, 1322–1326.Google Scholar
Murphy, D. L., Wright, C., Buchsbaum, M., et al (1976) Platelet and plasma oxidase activity in 680 normals: sex and age differences and stability over time. Biochemical Medicine, 16, 254–265.CrossRefGoogle Scholar
Murphy, D. L., Belmaker, R. H., Buchsbaum, M. S., et al (1977) Biogenic amine-related enzymes and personality variations in normals. Psychological Medicine, 7, 149–157.Google Scholar
Perris, C., Eisemann, M., Von Knorring, L., et al (1984) Personality traits and monoamine oxidase activity in platelets in depressed patients. Neuropsychobiology, 12, 201–205.Google Scholar
Puzynski, S., Hauptmann, M. & Zaluska, M. (1983) Studies on biogenic amine metabolizing enzymes (DBH, COMT, MAO) and pathogenesis of affective illness: III Platelet monoamine oxidase activity in endogenous depression. Acta Psychiatrica Scandinavica, 67, 101–108.Google Scholar
Robinson, D. S., Lovenberg, W., Keiser, H., et al (1968) Effects of drugs on human blood platelet and plasma amine oxidase activity in vitro and in vivo . Biochemical Pharmacology, 17, 109–119.Google Scholar
Robinson, D. S., Davis, J. M., Nies, A., et al (1971) Relation of sex and ageing to monoamine oxidase activity of human brain, plasma and platelets. Archives of General Psychiatry, 24, 536–539.Google Scholar
Rotman, A. (1982) Blood platelets in psychopharmacological research. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 7, 135–151.Google Scholar
Sandler, M., Youdim, M. B. H. & Hannington, E. (1974) A defect in phenylethylamine deamination in migraine patients. Nature, 250, 335–336.Google Scholar
Sandler, M., Reveley, M. A. & Glover, V. (1981) Human platelet monoamine oxidase activity in health and disease: a review. Journal of Clinical Pathology, 34, 292–302.Google Scholar
Schooler, C., Zahn, T. P., Murphy, D. L., et al (1978) Psychological correlates of monoamine oxidase activity in normals. Journal of Nervous and Mental Disease, 166, 177–186.Google Scholar
Sheehan, D. V., Coleman, J. H., Greenblatt, D. J., et al (1984) Some biochemical correlates of panic attacks with agoraphobia and their response to a new treatment. Journal of Clinical Psychopharmacology, 4, 66–75.CrossRefGoogle ScholarPubMed
Tuomisto, T. & Tukiainen, E. (1976) Decreased uptake of 5-hydroxytryptamine in blood platelets from depressed patients. Nature, 262, 596–598.Google Scholar
White, K., Shih, J., Fong, T. L., et al (1980) Elevated platelet monoamine oxidase activity in patients with nonendogenous depression. American Journal of Psychiatry, 137, 1258–1259.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. An instruction manual for the PSE and Catego program. Cambridge: Cambridge University Press.Google Scholar
Woods, H. F., Youdim, M. B. H., Boullin, D., et al (1977) Monoamine metabolism and platelet function in iron-deficiency anaemia. In Iron Metabolism, Ciba Foundation Symposium 51, New Series, pp. 227–248. Amsterdam: Elsevier.CrossRefGoogle Scholar
Yu, P. H., Bowen, R. C., Davis, B. A., et al (1983) Platelet monoamine oxidase activity and trace acid levels in plasma of agoraphobic patients. Acta Psychiatrica Scandinavica, 67, 188–194.Google Scholar
Zeller, E. A. & Davis, J. M. (1980) Protein content and monoamine oxidase activity in platelets. Schizophrenia Bulletin, 6, 267–274.CrossRefGoogle ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.