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Platelet Monoamine Oxidase Activity and 5-Hydroxytryptamine Uptake in Agoraphobic Patients

Published online by Cambridge University Press:  02 January 2018

J. Flaskos ,
N. Theophilopoulos  and
A. J. George
J. Flaskos
Affiliation:
Pharmacology Department, School of Pharmacy, Liverpool Polytechnic and University Department of Psychiatry, Liverpool University
N. Theophilopoulos
Affiliation:
Pharmacology Department, School of Pharmacy, Liverpool Polytechnic and University Department of Psychiatry, Liverpool University
A. J. George*
Affiliation:
University Department of Psychiatry, Liverpool University; Department of Psychiatry, Tameside General Hospital
*
∗Liverpool Polytechnic, Byron Street, Liverpool L3 3AF
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Abstract

Platelet MAO activity and platelet serotonin uptake were determined in 20 agoraphobic and 16 neurotic depressive out-patients, and 19 healthy volunteers. Agoraphobic patients were characterised by significantly higher mean values of platelet MAO activity compared with the other two groups, while neurotic depressive patients exhibited significantly higher maximum platelet serotonin uptake velocity. These findings are compatible with an abnormality in the uptake and metabolism of serotonin.

Type
Papers
Information
The British Journal of Psychiatry , Volume 155 , Issue 5 , November 1989 , pp. 680 - 685
Copyright
Copyright © Royal College of Psychiatrists, 1989 

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