Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-19T05:23:32.733Z Has data issue: false hasContentIssue false
  • English
  • Français

Plasma Viscosity in Mental Deficiency and Down's Syndrome

Published online by Cambridge University Press:  29 January 2018

R. D. Eastham ,
J. Jancar  and
Ethel H. L. Duncan
R. D. Eastham
Affiliation:
Frenchay/Cossham Group of Hospitals, Bristol
J. Jancar
Affiliation:
Stoke Park and Hortham-Brentry Hospital Groups, Bristol
Ethel H. L. Duncan
Affiliation:
Department of Public Health, University of Bristol
Get access Rights & Permissions [Opens in a new window]

Extract

Increase in serum gamma globulin concentration with reciprocal reduction in serum albumin concentration is commonly found in patients suffering from Down's syndrome (mongolism) (Carver et al., 1959; Nelson, 1961; Pritham et al., 1963). It is possible that gamma globulin of relatively less effective composition than normal is produced, and that hospitalized living increases production of this faulty protein (Pritham et al., 1963). On the other hand, Polani (1962) suggested that in Down's syndrome there is either exaggerated or diminished response to drugs and hormones, and the raised gamma globulin levels could result from an excessive production of normal gamma globulin, possibly in response to infection.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 111 , Issue 479 , October 1965 , pp. 999 - 1002
Copyright
Copyright © Royal College of Psychiatrists, 1965 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Carver, M. J., and Welton, L. D. (1961). “Studies on serum protein fractions from mongoloids” Dis. nerv. Syst., 22, 84–86.Google Scholar
Carver, M. J., Wiltshe, H., and Wittson, C. L. (1959). “Basic studies in mongolism I. Serum Proteins” Ibid., 20, 162–164.Google Scholar
Eastham, R. D., and Jancar, J. (1965). “Plasma viscosity in cases of severe mental subnormality” Amer. J. ment. Defic., 69, 502–505.Google Scholar
Hardwicke, J., and Squire, J. R. (1952). “The basis of the erythrocyte sedimentation rate” Clin. Sci., 11, 333–353.Google Scholar
Harkness, J. (1963). “A new instrument for the measurement of plasma viscosity” Lancet, ii, 280–281.Google Scholar
Harkness, J. (1964). Personal Communication.Google Scholar
Kaplitz, S. E., Dubin, A., and Bronsky, D., (1964). “Serum proteins in Down's syndrome (mongolism)” Amer. J. ment. Defic., 69, 236–238.Google Scholar
Nelson, T. L. (1961). “Serum proteins and lipoprotein fractions in mongolism,” Amer. J. Dis. Child., 102, 369–374.Google Scholar
Polani, P. E. (1962). “Chromosome abnormalities as a cause of defective development”, in Aspects of Psychiatric Research. Ed. D. Richter, J. M. Tanner, Lord Taylor, and O. L. Zangwill London: Oxford University Press.Google Scholar
Pritham, G. H., Appleton, M. D., and Fluck, E. R. (1963). “Biochemical studies in mongolism. I. The influence of environment on the concentrations and mobilities of plasma proteins” Amer. J. ment. Defic., 67, 517–52:.Google Scholar
Skanse, B., and Laurell, C. B. (1962). “The immune-globulins in mongolism” Acta. med. scand., 172, 63–65.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.