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Plasma Levels of Fluphenazine Decanoate

Effects of site of injection, massage and muscle activity

Published online by Cambridge University Press:  02 January 2018

Som D. Soni ,
David Wiles ,
A. A. Schiff  and
J. S. Bamrah
Som D. Soni*
Affiliation:
Prestwich and Hope Hospitals, Manchester
David Wiles
Affiliation:
Crichton Royal Hospital, Dumfries
A. A. Schiff
Affiliation:
E. R. Squibb and Sons, Hounslow
J. S. Bamrah
Affiliation:
Prestwich Hospital, Manchester
*
∗Psychiatric Research Department, Salford Health Authority, Prestwich and Hope Hospitals, Prestwich, Manchester M25 7BL
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Abstract

Depot neuroleptics are now commonly used for maintenance therapy of schizophrenia. Their physicochemical composition makes them ideal for such use because they are long-acting and show stable blood levels for prolonged periods. Their absorption from the site of injection may, however, be affected by local muscle factors. This paper describes three such factors in relation to fluphenazine decanoate: varying the site of injection; massage of the injection site; and effects of muscular exercise. Our results suggest that fluphenazine pharmacokinetics are not significantly affected by any of these factors.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 153 , Issue 3 , September 1988 , pp. 382 - 384
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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References

Cockshott, W. P., Thompson, G. T., Howlett, L. J. & Selley, E. T. (1982) Intramuscular or intralipomatous injections? New England Journal of Medicine, 307, 356–358.Google Scholar
Cohen, L. S., Rosenthal, J. E., Horner, D. W. Jr, Atkins, J. M., Mathews, O. A. & Sarnoff, S. J. (1972) Plasma levels of lidocaine after intramuscular injections. American Journal of Cardiology, 29, 520–523.Google Scholar
Diem, E. & Lentner, C. (eds) (1970) Documenta Geigy Scientific Tables (7th ed), p. 561.Google Scholar
Hansen, L. B. & Kristensen, J. H. (1973) Effect of massage, shortwave diathermy and ultrasound upon 133Xe disappearance rate from muscle and subcutaneous tissue in human calf. Scandinavian Journal of Rehabilitation Medicine, 5, 179–182.Google Scholar
Schwartz, M. L., Meyer, M. B. & Covino, M. G. (1974) Antiarrhythmic effectiveness of lidocaine: influence of different injection sites. Journal of Clinical Pharmacology, 14, 77–83.Google Scholar
Svendson, O., Dencker, S. J., Fog, R., Graven, A. O. & Kristjansen, P. (1980) Evidence of lymphogenic absorption of oil in humans receiving neuroleptic oily depot preparations intramuscularly. Acta Pharmacologica Toxicol, 47, 157–158.Google Scholar
Wiles, D. H. & Franklin, M. (1978) Radioimmunoassay of fluphenazine in human plasma. British Journal of Clinical Pharmacology, 5, 265–268.Google Scholar
Wiles, D. H. & Gelder, M. G. (1979) Plasma fluphenazine levels by radioimmunoassay in schizophrenic patients treated with depot injections of fluphenazine decanoate. British Journal of Clinical Pharmacology, 8, 565–570.Google Scholar
Wode-Helgodt, B., Borg, S., Fyro, B. & Sedvall, G. (1978) Clinical effects and drug concentration in plasma and cerebrospinal fluid in psychotic patients treated with fixed dosed of chlorpromazine. Acta Psychiatrica Scandinavica, 58, 149–173.Google Scholar
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