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Plasma Levels of β-Endorphin in Depressed Patients

With and without Pain

Published online by Cambridge University Press:  02 January 2018

R. J. Daly ,
P. F. Duggan ,
P. J. Bracken ,
H. J. Doonan  and
N. J. Kelleher
R. J. Daly*
Affiliation:
Professorial Psychiatric Unit
P. F. Duggan
Affiliation:
Biochemistry Laboratory
P. J. Bracken
Affiliation:
Professorial Psychiatric Unit
H. J. Doonan
Affiliation:
Department of Psychiatry
N. J. Kelleher
Affiliation:
Biochemistry Laboratory
*
∗Cork Regional Hospital, Wilton, Cork, Ireland
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Abstract

We studied 27 patients who complained of pain, for which no organic basis could be found, and 11 patients without pain. All patients were depressed according to clinical diagnosis and Beck Depression Inventory (BDI) scores. Plasma β-endorphin levels were found not to differ between the two groups or across other variables. The patients who complained of pain had significantly higher scores on the BDI.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 150 , Issue 2 , February 1987 , pp. 224 - 227
Copyright
Copyright © 1987 The Royal College of Psychiatrists 

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References

Alexopoulos, C. E., Inturrisi, C. E., Lipman, R., Frances, R., Haycox, J., Dougherty, J. H. & Rossier, J. (1983) Plasma immunoreactive beta-endorphin levels in depression. Archives of General Psychiatry, 40, 181–183.CrossRefGoogle ScholarPubMed
Almay, B. G. L., Johanssen, F., Von Knorring, L., Terenius, L. & Wahlström, A. (1978) Endorphins in chronic pain: 1. Differences in CSF endorphin levels between organic and psychogenic pain syndrome. Pain, 5, 153–162.Google Scholar
Atkinson, J. M. Kremer, E. F., Risch, S. C., Morgan, C. D., Azad, R. F., Ehlers, L. L. & Bloom, F. E. (1983) Plasma measures of beta-endorphin/beta-lipotropin-like immunoreactivity in chronic pain syndrome and psychiatric subjects. Psychiatry Research, 9, 319–327.Google Scholar
Beck, A. T., Ward, C. H., Mendelson, M., Mock, J. E. & Erbaugh, J. K. (1961) An inventory for measuring depression. Archives of General Psychiatry, 4, 561–571.Google Scholar
Brambilla, F., Genazzani, A. R., Facchinetti, F., Parrini, D., Petraglia, F., Sacchetti, E., Scarone, S., Guastalla, A. & D'Antona, N. (1981) Beta-endorphin and beta-lipotropin plasma levels in chronic schizophrenia, primary affective disorders and secondary affective disorders. Psychoendocrinology, 6, 321–330.CrossRefGoogle ScholarPubMed
Cohen, M. R., Pickar, D., Extein, I., Gold, M. S. & Sweeney, D. R. (1984) Plasma cortisol and beta-endorphin immunoreactivity in nonmajor and major depression. American Journal of Psychiatry, 141, 628–632.Google Scholar
Davis, G. C. (1983) Endorphins and pain. Psychiatric Clinics of North America, 6, 473–487.CrossRefGoogle ScholarPubMed
Garvey, M. J., Schaffer, C. B. & Tuason, V. B. (1983) Relationship of headaches to depression. British Journal of Psychiatry, 143, 544–547.Google Scholar
Gerner, R. H. & Sharp, B. (1982) CSF beta-endorphin immunoreactivity in normal, schizophrenic, depressed, manic and anorexic subjects. Brain Research, 237, 244–247.Google Scholar
Kriegar, D. T. & Liotta, A. S. (1979) Pituitary hormones in brain. Where, how and why? Science, 205, 366–372.Google Scholar
Mains, R. E., Eipper, B. A. & Lino, N. (1977) Common precursor to corticotropins and endorphins. Proceedings of the National Academy of Science USA, 74, 3014–3018.Google Scholar
Merskey, H. & Spear, F. G. (1967) Pain, Psychological and Psychiatric Aspects. London: Bailliere, Tindall & Cassell.Google Scholar
Naber, D., Pickar, D., Post, R. M., Van Kammen, D. P., Waters, R. N., Ballenger, J. C., Goodwin, F. K. & Bunney, W. E. (1981) Endogenous opioid activity and beta-endorphin immunoreactivity in CSF of psychiatric patients and normal volunteers. American Journal of Psychiatry, 138, 1457–1462.Google Scholar
Ohnhaus, E. E. & Adler, R. (1975) Methodological problems in the measurement of pain: a comparison between the verbal rating scale and the visual analogue scale. Pain, 4, 375–378.Google Scholar
Risch, S. C. (1982) Beta-endorphin hypersecretion in depression: possible cholinergic mechanisms. Biological Psychiatry, 17, 1071–1079.Google ScholarPubMed
Rossier, J., French, E., Guillerin, P. et al (1980) On the mechanisms of the simultaneous release of immunoreactive beta-endorphin, ACTH and prolactin by stress. In Neural Peptides and Neuronal Communications (eds E. Costa & M. Trabuchi). New York: Raven Press.Google Scholar
Rubinow, D. R., Post, R. M., Pickar, D. et al (1981) Relationship between urinary-free cortisol and CSF opioid binding activity in depressed patients and normal volunteers. Psychiatry Research, 5, 87–93.Google Scholar
Terenius, L., Wahlstrom, A. & Agren, J. (1977) Naloxone treatment in depression: clinical observations and effects on CSF and endorphins and monoamine metabolites. Psychopharmacology, 54, 31–33.CrossRefGoogle ScholarPubMed
Willer, J. C., Shery-Shu, L., Bertagna, X. & Girard, F. (1984) Pituitary beta endorphin not involved in pain control in some patho-physiological conditions. Lancet, 2, 295–296.Google Scholar
Woolf, C. J. & Wall, P. D. (1983) Endogenous opioid peptides and pain mechanisms: a complex relationship. Nature, 306, 739–740.Google Scholar
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