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Plasma Levels of Antidiuretic Hormone in Patients Receiving Prolonged Lithium Therapy

Published online by Cambridge University Press:  29 January 2018

P. L. Padfield ,
S. J. Park ,
J. J. Morton  and
A. E. Braidwood
P. L. Padfield
Affiliation:
Medical Research Council, Blood Pressure Unit, Western Infirmary, Glasgow G11 6NT; and Gartnavel Royal Psychiatric Hospital, Glasgow G12 0XH
S. J. Park
Affiliation:
Medical Research Council, Blood Pressure Unit, Western Infirmary, Glasgow G11 6NT; and Gartnavel Royal Psychiatric Hospital, Glasgow G12 0XH
J. J. Morton
Affiliation:
Medical Research Council, Blood Pressure Unit, Western Infirmary, Glasgow G11 6NT; and Gartnavel Royal Psychiatric Hospital, Glasgow G12 0XH
A. E. Braidwood
Affiliation:
Medical Research Council, Blood Pressure Unit, Western Infirmary, Glasgow G11 6NT; and Gartnavel Royal Psychiatric Hospital, Glasgow G12 0XH
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Summary

Among 18 patients receiving prophylactic, long-term lithium treatment for manic-depressive psychosis, a high incidence of increased thirst and frequency of micturition (60–70 per cent) was noted on direct questioning. Symptoms arose at varying times after the start of lithium therapy; in no patient did symptoms antedate the use of the drug.

Plasma levels of antidiuretic hormone were found, on average, to be higher than in normal control subjects for a given level of plasma osmolality, although the scatter of results was wide. It is suggested that elevation of antidiuretic hormone occurs as a compensatory mechanism for the polyuria which is a common feature of long-term lithium treatment. The more florid form of nephrogenic diabetes insipidus occasionally seen in lithium takers seems likely to be due to a different mechanism from the more common mild polyuria.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 130 , Issue 2 , February 1977 , pp. 144 - 147
Copyright
Copyright © Royal College of Psychiatrists 1977 

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References

Angrist, M. B., Gershon, S., Levitan, S.J. & Blumberg, A. G. (1970) Lithium induced diabetes insipidus-like syndrome. Comprehensive Psychiatry, 11, 141–6.CrossRefGoogle ScholarPubMed
Baastrup, P. C., Poulsen, J. C., Schou, M., Thomsen, K. & Amdisen, A. (1970) Prophylactic lithium: double blind discontinuation in manic depressive and recurrent depressive disorders. Lancet, ii, 326–30.Google Scholar
Baastrup, P. C., & Schou, M. (1967) Lithium as a prophylactic agent. Archives of General Psychiatry, 16, 162–8.Google Scholar
Blinjenberg, B. G. & Leijnse, B. (1968) The determination of lithium in serum by atomic absorption spectroscopy and flame emission spectroscopy. Clinica Chimica Acta, 19, 97–100.Google Scholar
Coppen, A., Noguera, R., Bailey, J., Burns, B. H., Swani, M. A., Hare, E. H., Gardner, R. & Maggs, R. (1971) Prophylactic lithium in affective disorders, Lancet, ii, 275–9.Google Scholar
Czaczes, J. W. & Kleeman, C. R. (1964) The effect of various states of hydration and the plasma concentration on the turnover of antidiuretic hormone in mammals. Journal of Clinical Investigation, 4, 1649–58.Google Scholar
Evan, A. P. & Ollerich, D. A. (1972) The effect of lithium carbonate on the structure of the kidney. American Journal of Anatomy, 134, 97–106.Google Scholar
Forrest, J. N., Cohen, A. D., Torretti, J., Himmelhoch, J. M. & Epstein, F. H. (1974) On the mechanism of lithium-induced diabetes insipidus in man and rat. Journal of Clinical Investigation, 53, 1115–23.Google Scholar
Geisler, A., Wraae, O. & Oleson, O. V. (1972) Adenyl cyclase activity in kidneys of rats with lithium-induced polyuria. Acta Pharmacologica et Toxicologia, 31, 203–8.Google ScholarPubMed
Harris, C. A. & Jenner, F. A. (1972) Some aspects of the inhibition of the action of antidiuretic hormone by lithium ions in the rat kidney and bladder of the toad Bufo marinus. British Journal of Pharmacology, 44, 223–32.Google Scholar
Jenner, F. A. & MacNeil, S. (1975) The effects of lithium ions on the antidiuretic action of vasopressin in the rat. British Journal of Pharmacology, 55, 527–34.Google Scholar
Lee, R. V., Jampol, L. M. & Braun, W. V. (1971) Nephrogenic diabetes insipidus and lithium intoxication: complications of lithium carbonate. New England Journal of Medicine, 284, 93.Google Scholar
Lindop, G. B. M. & Padfield, P. L. (1975) The renal pathology in a case of lithium-induced diabetes insipidus. Journal of Clinical Pathology, 28, 472–5.CrossRefGoogle Scholar
MacNeil, S., Jennings, G., Eastwood, P. R., Paschalis, C. & Jenner, F. A. (1976) Lithium and the antidiuretic hormone. British Journal of Clinical Pharmacology, 3, 305–14.CrossRefGoogle ScholarPubMed
Miller, M. & Moses, A. M. (1972) Urinary antidiuretic hormone in polyuric disorders and the inappropriate ADH syndrome. Annals of Internal Medicine, 77, 715–21.Google Scholar
Morton, J. J., Forsling, M. & Padfield, P. L. (1975) A radioimmunoassay for plasma arginine vasopressin in man and dog. Journal of Endocrinology, 65, 411–24.CrossRefGoogle ScholarPubMed
Padfield, P. L., Morton, J. J., Lindop, G. B. M. & Timbury, G. C. (1975) Lithium-induced nephrogenic diabetes insipidus; changes in plasma vasopressin and angiotensin, II. Clinical Nephrology, 3, 220–4.Google ScholarPubMed
Radomski, J. L., Fuyat, H. N., Nelson, A. A. & Smith, P. K. (1950) The toxic effects of excretion and distribution of lithium chloride. Journal of Pharmacology, 100, 429–44.Google ScholarPubMed
Ramsay, T. A., Mendels, J., Stokes, J. W. & Fitzgerald, R. G. (1972) Lithium carbonate and kidney function: a failure in renal concentrating ability. Journal of the American Medical Association, 219, 1446–9.Google Scholar
Schou, M. (1959) Lithium in psychiatric therapy. Psychopharmacologia, 1, 65–78.CrossRefGoogle ScholarPubMed
Singer, I., Rotenberg, D. & Puschett, J. B. (1972) Lithium-induced nephrogenic diabetes insipidus in vivo and in vitro studies. Journal of Clinical Investigation, 51, 1081–91.CrossRefGoogle ScholarPubMed
Voil, G. W. & Smith, E. K. M. (1971) Vasopressin inhibition by lithium. New England Journal of Medicine, 284, 674–5.Google Scholar
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