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Plasma Cortisol Levels in Mania: Associated Clinical Ratings and Changes during Treatment with Haloperidol

Published online by Cambridge University Press:  29 January 2018

J. C. Cookson ,
T. Silverstone ,
S. William  and
G. M. Besser
J. C. Cookson*
Affiliation:
Academic Unit of Human Psychopharmacology, Medical Colleges of The London Hospital and St Bartholomew's Hospital
T. Silverstone
Affiliation:
Academic Unit of Human Psychopharmacology, Medical Colleges of The London Hospital and St Bartholomew's Hospital
S. William
Affiliation:
Medical College of St Bartholomew's Hospital
G. M. Besser
Affiliation:
Medical College of St Bartholomew's Hospital
*
∗Correspondence: The London Hospital (St Clement's), 2a Bow Road, London E3 4LL.
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Summary

Plasma Cortisol levels were elevated in a large proportion of samples from manic patients. Although a correlation was found between clinical ratings of the severity of mania and the degree of elevation of daytime Cortisol levels, some patients with low clinical ratings had elevated Cortisol levels. During treatment with haloperidol, Cortisol levels returned to normal earlier that the clinical state. The underlying mechanisms are discussed.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 146 , Issue 5 , May 1985 , pp. 498 - 502
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

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