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Plasma Cortisol Levels in Mania: Associated Clinical Ratings and Changes during Treatment with Haloperidol

Published online by Cambridge University Press:  29 January 2018

J. C. Cookson ,
T. Silverstone ,
S. William  and
G. M. Besser
J. C. Cookson*
Affiliation:
Academic Unit of Human Psychopharmacology, Medical Colleges of The London Hospital and St Bartholomew's Hospital
T. Silverstone
Affiliation:
Academic Unit of Human Psychopharmacology, Medical Colleges of The London Hospital and St Bartholomew's Hospital
S. William
Affiliation:
Medical College of St Bartholomew's Hospital
G. M. Besser
Affiliation:
Medical College of St Bartholomew's Hospital
*
∗Correspondence: The London Hospital (St Clement's), 2a Bow Road, London E3 4LL.
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Summary

Plasma Cortisol levels were elevated in a large proportion of samples from manic patients. Although a correlation was found between clinical ratings of the severity of mania and the degree of elevation of daytime Cortisol levels, some patients with low clinical ratings had elevated Cortisol levels. During treatment with haloperidol, Cortisol levels returned to normal earlier that the clinical state. The underlying mechanisms are discussed.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 146 , Issue 5 , May 1985 , pp. 498 - 502
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

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References

Akesode, A., Hendler, N. & Kowarski, A. A. (1976) A 24 hour monitoring of the integrated plasma concentration of aldosterone and Cortisol in manic patients. Psychoneuroendocrinology, 1, 419–426.Google Scholar
Anden, N. E., Butcher, S. G., Corrodi, H., Fuxe, F. & Ungerstedt, U. (1970). Receptor activity and turnover of dopamine and noradrenaline after neuroleptics. European Journal of Pharmacology, 11, 303–314.Google Scholar
Besser, G. M., Butler, P. W. P., Landon, J. & Rees, L. (1969) Influence of amphetamine on plasma corticosteroid and growth hormone levels in man. In British Medical Journal, iv, 528–530.CrossRefGoogle Scholar
Besser, G. M. & Edwards, C. R. W. (1972) Cushing's Syndrome. Clinics in Endocrinology and Metabolism, 1, 451–490.Google Scholar
Butler, P. W. P. & Besser, G. M. (1968) Pituitary adrenal function in severe depressive illness. In Lancet, i, 1234–1236.Google Scholar
Butler, P. W. P. & Besser, G. M. & Steinberg, H. (1968) Changes in plasma Cortisol induced by dexamphetamine and chlordiazepoxide given alone and in combination in man. Journal of Endocrinology, 40, 391–392.Google Scholar
Carpenter, W. C. & Bunney, W. E. (1971) Diurnal rhythm of Cortisol in mania. Archives of General Psychiatry, 25, 270–273.Google Scholar
Carroll, B. J. (1979) Neuroendocrine function in mania. In Manic Illness (ed. Shopsin, B.) New York: Raven Press.Google Scholar
Cookson, J. C., Moult, P. J. A., Wiles, D. & Besser, G. M. (1983) The relationship between prolactin levels and clinical ratings in manic patients treated with oral and intravenous test doses of Haloperidol. Psychological Medicine, 13, 279–285.CrossRefGoogle ScholarPubMed
Cookson, J. C., Silverstone, T., Besser, G. M. & Williams, S. (1980) Plasma corticosteroids in mania: The effects of pimozide. Neuropharmacology, 19, 1243–1244.Google Scholar
Cookson, J. C., Silverstone, T. & Rees, L. H. (1982) Plasma prolactin and growth hormone levels in manie patients treated with pimozide. British Journal of Psychiatry, 140, 274–280.Google Scholar
Evans, D. L. & Nemeroff, C. B. (1983) The dexamethasone suppression test in mixed bipolar disorder. American Journal of Psychiatry, 140, 615–617.Google Scholar
Gerner, R. H. & Wilkins, J. N. (1983) CSF Cortisol in patients with depression, mania or anorexia nervosa and in normal subjects. American Journal of Psychiatry, 140, 92–94.Google Scholar
Graham, P. M., Booth, J., Borange, G., Galhenage, S., Myers, C. M., Teoh, C. J. & Cox, L.S. (1982) The dexamethasone suppression test in mania. Journal of Affective Disorders, 4, 201–211.Google Scholar
Greden, J. F., De Vinge, J. P., Albala, A. A., Tarika, J., Bultenheim, M., Eiser, A. & Carroll, B. J. (1982) Serial dexamethasone suppression tests among rapidly cycling bipolar patients, Biological Psychiatry, 17, 455–462.Google Scholar
Grossman, A. & Besser, G. M. (1982) Opiates control ACTH through a noradrenergic mechanism. Clinical Endocrinology, 17, 287–290.Google Scholar
Kellner, C.H., Rubinow, D.R., Gold, P. W. & Post, R. M. (1983) Relationship of Cortisol hypersecretion to brain CT scan alterations in depressed patients. Psychiatry Research, 8, 191–197.CrossRefGoogle Scholar
Krishnan, P. R., Maltbie, A. A. & Davidson, J. R. (1983) Abnormal Cortisol suppression in bipolar patients with simultaneous manic and depressive symptoms. American Journal of Psychiatry, 140, 203–205.Google Scholar
Peroutka, S. J. & Snyder, S. H. (1980) Relationship of neuroleptic drug effects at brain dopamine, serotonin, ∞-adrenergic, and histamine receptors to clinical potency. American Journal of Psychiatry, 137, 1518–1522.Google Scholar
Petterson, R., Fyro, B. & Sedval, G. (1973) A new scale for longitudinal rating of manic states. Acta Psychiatrica Scandinavica, 49, 248–256.Google Scholar
Platman, S. R. & Fieve, R. R. (1968) Lithium carbonate and plasma Cortisol response in affective disorders. Archives of General Psychiatry, 18, 591–594.Google Scholar
Post, R. M., Lake, C. R., Jimerson, D. R., Bunney, W. E., Wood, S. H., Siegler, M. G. & Goodwin, F. K. (1978) Cerebrospinal fluid norepinephrine in affective illness. American Journal of Psychiatry, 135, 907–912.Google Scholar
Rees, L., Butler, P. W. P., Gosling, C. & Besser, G. M. (1970) Adrenergic blockade and the corticosteroid and growth hormone response to methylamphetamine. Nature, 228, 565–566.Google Scholar
Sachar, E. J. (1975) 24 hour Cortisol secretory patterns in depressed and manic patients. In Hormones, Homeostasis and the Brain, (eds. Gispen, W. H. et al) Amsterdam; Elsevier.Google Scholar
Schildkraut, J. J. (1965) Catecholamine hypothesis of affective disorders: Review of supporting evidence. American Journal of Psychiatry, 122, 509–522.Google Scholar
Schlesser, M. A., Winokur, G. & Sherman, B. M. (1980) Hypothalamic-adrenal axis activity in depressive illness. Archives of General Psychiatry, 37, 737–743.Google Scholar
Silverstone, T. & Cookson, J. C. (1982) The biology of mania. In Recent Advances in Clinical Psychiatry, Volume 4 (ed. Granville-Grossman, K.) Edinburgh: Churchill-Livingstone.Google Scholar
Swann, A. C., Davis, J., Maas, J., Secunda, S., Kocsis, J., Javaid, J. & Chang, S. (1984). Lithium treatment of mania: behavioural and neurochemical changes. Proceedings of the 14th CINP Congress. Clinical Neuropharmacology, 7, Suppl. 1., 830–831.Google Scholar
Swann, A. C., Secunda, S., Davis, J. M., Robins, E., Hanin, I., Koslow, S. H. & Mass, J. W. (1983). CSF monoamine metabolites in mania. American Journal of Psychiatry, 140, 396–400.Google Scholar
Swigar, M. E., Kolakowska, T. & Ouinlan, D. M. (1979) Plasma Cortisol levels in depression and other psychiatric disorders: a study of newly admitted psychiatric patients. Psychological Medicine, 9, 449–455.CrossRefGoogle ScholarPubMed
Szabadi, E., Gaszner, P. & Bradshaw, C. M. (1981) An investigation of the-adrenoceptor blocking properties of neuroleptics in the human iris in vivo. British Journal of Clinical Pharmacology, 11, 416–417.Google Scholar
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