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Pituitary and Adrenal Function in Undernutrition with Mental Illness

(including Anorexia Nervosa)

Published online by Cambridge University Press:  29 January 2018

V. Marks  and
R. G. Bannister
V. Marks
Affiliation:
Area Laboratory, at West Park Hospital, Epsom, Surrey
R. G. Bannister
Affiliation:
University Unit in Clinical Neurology, The National Hospital, Queen Square, London
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Extract

Urinary excretion of adrenal metabolites, especially neutral 17-ketosteroids, is often low in patients with anorexia nervosa (Escamilla, 1949; Bliss and Branch, 1960). This has been taken (Emanuel, 1956; Greenblatt et al., 1951) to provide evidence of adreno-cortical insufficiency secondary to defective pituitary function (Sheldon, 1939; Perloff et al., 1954). According to Perloff et al. (1954) “prolonged starvation may result in functional hypopituitarism, whose differentiation from the syndrome of hypopituitary cachexia due to structural impairment of the anterior pituitary gland is at times extremely difficult, even when the accepted tests for endocrine adequacy are performed”.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 109 , Issue 461 , July 1963 , pp. 480 - 484
Copyright
Copyright © Royal College of Psychiatrists, 1963

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