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Pipothiazine Palmitate in the Management of Aggressive Mentally Handicapped Patients

Published online by Cambridge University Press:  29 January 2018

D. M. Lynch ,
C. L. S. Eliatamby  and
A. A. Anderson
D. M. Lynch
Affiliation:
Turner Village Hospital, Colchester, Essex CO4 5JP
C. L. S. Eliatamby
Affiliation:
Essex Hall Hospital, Colchester, Essex CO1 1XE
A. A. Anderson
Affiliation:
Department of Clinical Research, May & Baker Ltd., Dagenham, Essex RM10 7XS
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Summary

The efficacy of intramuscular pipothiazine palmitate (PP) in the management of aggressive mentally handicapped patients was examined in a double-blind, placebo-controlled, cross-over study, in which 30 patients received each treatment for 13 weeks. A target symptom scale of aggressiveness (TSA) and a clinical global impression scale of efficacy were rated at monthly intervals, and an extra-pyramidal side-effects scale weekly. The patients showed marked improvement during treatment with PP, which was assessed as superior to placebo. Individual and total TSA scores were also reduced compared to placebo.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 146 , Issue 5 , May 1985 , pp. 525 - 529
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

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