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A Pharmacological Profile of Fluoxetine and Other Antidepressants on Aspects of Skilled Performance and Car Handling Ability

Published online by Cambridge University Press:  06 August 2018

Ian Hindmarch
Ian Hindmarch*
Affiliation:
Human Psychopharmacology Research Unit, University of Leeds
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Extract

The measurement of the effects of an antidepressant on psychomotor ability and cognitive processing tests is important for three reasons. Firstly, because a change in psychomotor and cognitive function is one of the truly objective assessments of psychotropic activity of a drug. Secondly, since batteries of psychological tests are often analogues of the essential aspects of real-life behaviour, performance changes can reflect the potential impairment of the activities of everyday living such as car driving, operating industrial machinery, and domestic tasks. Thirdly, since Widlocher (1983a,b) has proposed that mental and psychomotor retardation are a primary expression of depressive illness, psychomotor and cognitive tests can be used to measure the extent to which a putative antidepressant affects these psychological functions. Psychopharmacological testing can thus indicate the ‘safety’ of the drug in clinical usage by establishing an index of the behavioural ‘toxicity’ of the substance. It can also objectively determine the magnitude of the drug's psychoactive properties, and the extent to which a particular compound affects information processing and cognitive function. Substances which have a negative action on these aspects of psychological integrity could be regarded as counter-therapeutic, as they are making psychomotor and mental functions worse.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 153 , Issue S3: Progress in Antidepressant Therapy , September 1988 , pp. 99 - 104
Copyright
Copyright © 1988 The Royal College of Psychiatrists 

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References

Ban, T. A. & Lehmann, H. E. (1973) Systematic clinical studies with trazodone: methodological aspects. Current Therapeutics Research - Clinical and Experimental, 15, 764–769.Google ScholarPubMed
Ban, T. A., Amin, M., Galvan, L., Nair, N. P. V., Vergara, L. & Zoch, C. (1973) Comprehensive clinical studies with trazodone. Current Therapeutic Research, 15, 540–551.Google ScholarPubMed
Crome, P. & Newman, B. (1978) A comparison of the effects of single doses of mianserin and amitriptyline on psychomotor tests in normal volunteers. Journal of International Medical Research, 6, 430–434.CrossRefGoogle ScholarPubMed
Dimascio, A., Klerman, G. L., Rinkel, H., Greenblatt, M. & Brown, J. (1958) Psychophysiologic evaluation of phenylolox-amine: a new phrenotropic agent. American Journal of Psychiatry, 115, 301–317.CrossRefGoogle ScholarPubMed
Fink, M., Irwin, P., Gastpar, M. & De Ridder, J. J. (1977) EEG, blood level and behavioural effects of the antidepressant mianserin. Psychopharmacology, 54, 249–254.CrossRefGoogle ScholarPubMed
Grundstrom, R., Holmberg, G., Lederman, H. & Livstedi, B. (1977) Sedative properties of doxepin in comparison with diazepam. Psychopharmacology, 54, 165–169.CrossRefGoogle ScholarPubMed
Hanks, G. W. (1984) The effect of amitriptyline and nomifensine on critical flicker fusion threshold in an elderly patient population. In Nomifensine: A Pharmacological and Clinical Profile, Royal Society of Medicine International Congress and Symposium Series No. 70 (eds L. W. Rees & R. G. Priest), pp. 71-76. Oxford: Oxford University Press.Google Scholar
Hindmarch, I. (1980) Psychomotor function and psychoactive drugs. British Journal of Clinical Pharmacology, 10, 189–209.CrossRefGoogle ScholarPubMed
Hindmarch, I. (1982a) Antidepressant drugs and performance. The British Journal of Clinical Practice, 19, 73–77.Google Scholar
Hindmarch, I. (1982b) Critical flicker fusion frequency (CFFF): the effects of psychotropic compounds. Pharmacopsychiatry, 15 (Suppl. 1). 44–48.CrossRefGoogle Scholar
Hindmarch, I. (1986) The effects of psychoactive drugs on car handling and related psychomotor activity: a review. In Drugs and Driving (eds O'Hanlon, J. F. & De Gier, J. J.), pp. 71–82. London: Taylor & Francis.Google Scholar
Hindmarch, I. (1987a) Antidepressant drugs and cognitive function. In Quo Vadis: Diagnosis and Treatment of Depression (eds Biziere, K., Garattini, S. & Simon, P.), pp. 356–363. Paris: Medsi/McGraw Hill.Google Scholar
Hindmarch, I. (1987b) Three antidepressants (amitriptyline, dothiepin, fluoxetine), with and without alcohol, compared with placebo on tests of psychomotor ability related to car driving. Human Psychopharmacology, 2, 177–183.CrossRefGoogle Scholar
Hindmarch, I. & Bhatti, J. Z. (1988) The psychopharmacological effects of sertraline in normal, healthy volunteers. European Journal of Clinical Pharmacology (in press).CrossRefGoogle Scholar
Hindmarch, I. & Harrison, C. (1988) The effects of paroxetine and other antidepressants in combination with alcohol in psychomotor activity related to car driving. Human Psychopharmacology, 3, 13–20.CrossRefGoogle Scholar
Hindmarch, I. & Parrott, A. C. (1977) Repeated dose comparisons of nomifensine, imipramine and placebo on subjective assessments of sleep and objective measures of psychomotor performance. British Journal of Clinical Pharmacology, 4, 167S–173S.CrossRefGoogle Scholar
Hindmarch, I. & Subhan, Z. (1986) The effects of antidepressants, taken in conjunction with alcohol, on information processing and psychomotor performance related to car driving ability. In Drugs and Driving (eds O'Hanlon, J. F. & de Gier, J. J.), pp. 231–240. London: Taylor & Francis.Google Scholar
Hindmarch, I., Parrott, A. C. & Stonier, P. D. (1980) The effects of nomifensine and HOE 8476 on car driving and related psychomotor performance. In Nomifensine, Royal Society of Medicine International Congress and Symposium Series No. 25 (eds P. D. Stonier & F. A. Jenner), pp. 47-54. London: Academic Press.Google Scholar
Hindmarch, I., Subhan, Z. & Stoker, M. J. (1983) The effects of zimeldine and amitriptyline on car driving and psychomotor tests. Acta Psychiatrica Scandinavica, 68, 141–146.CrossRefGoogle Scholar
Hindmarch, I., Harrison, C. & Shillingford, C. A. (1988) An investigation of the effects of lofepramine, nomifensine, amitriptyline and placebo on aspects of memory and psychmotor performance related to car driving. International Journal of Clinical Pharmacology (in press).CrossRefGoogle Scholar
Hofner, K. J. (1978) The effects of a new antidepressant, mianserin, on performance related to car driving. Clinical Therapeutics, 1, 280–284.Google Scholar
Holmberg, G. (1981) Critical flicker fusion (CFF) test for sedative effects of anti-depressants. Acta Psychiatrica Scandinavica, 63 (Suppl. 290), 289–301.CrossRefGoogle Scholar
Khan, H. C., Mahapatra, S. N., Stonier, P. D. & Thomas, E. M. (1984) Nomifensine and mianserin: non-tricyclic antidepressants with distinct clinical profiles: a randomised double-blind study. In Nomifensine: A Pharmacological and Clinical Profile, Royal Society of Medicine International Congress and Symposium Series No. 70 (eds L. W. Rees & R. G. Priest), pp. 71-76. Oxford: Oxford University Press.Google Scholar
Parroti, A. C. (1982) Critical flicker fusion threshold and their relationship to other measures of alertness. Pharmacopsychiatrica, 15, 39–43.CrossRefGoogle Scholar
Peck, A. W., Bye, C. E., Clubley, M., Henson, T. & Riddington, C. (1979) A comparison of bupropion hydrochloride with dexamphetamine and amytriptyline in healthy subjects. British Journal of Clinical Pharmacology, 7, 469–478.CrossRefGoogle Scholar
Saakima, J. (1974) Trazodone: a review of the literature. Modern Problems in Pharmacopsychiatry (eds Ban, T. & Silvestrini, B.) Vol. 9, 95–100. Basel: Karger.Google Scholar
Seppala, T. (1977) Psychomotor skills during acute and two week treatment with mianserin and amitriptyline and their combined effects with alcohol. Annals of Clinical Research, 9, 66–72.Google ScholarPubMed
Seppala, T., Linnoila, M. & Mattila, M. J. (1976) Psychomotor skills in depressed out-patients treated with L-tryptophan, doxepin or chlorimipramine. Annals of Clinical Research, 10, 214–221.Google Scholar
Schaffler, K. (1986) Study on performance and alcohol interaction with the antidepressant fluoxetine, using computer assisted psychophysiological methodology. British Journal of Clinical Practice, 40, (Suppl. 46), 28–33.Google Scholar
Siegfried, K. (1988) Towards a clinical classification of antidepressant profiles. In Human Psychopharmacology (eds Hindmarch, I. & Stonier, P. D.) Vol. II. Chichester: Wiley.Google Scholar
Siegfried, K. & O'Connolly, M. (1986) Cognitive and psychomotor effects of different antidepressants in the treatment of old age depression. International Clinical Psychopharmacology, I, 221–230.Google Scholar
Siegfried, K., Jansen, W. & Pahnke, K. (1984) Cognitive dysfunction in depression, Drug Development Research, 4, 533–553.CrossRefGoogle Scholar
Silvestrini, B., Lisciani, R. & De Gregorio, M. (1980) Trazodone. In Pharmacological and Biochemical Properties of Drug Substances (ed. Goldberg, M. E.). Washington: American Psychiatric Press.Google Scholar
Widlocher, D. (1983a) Psychomotor retardation: clinical, theoretical and psychometric aspects. Psychiatrics Clinics of North America, 6, 27–39.CrossRefGoogle ScholarPubMed
Widlocher, D. (1983b) Le Ralentissement Depressif. Paris: Presses Universitaires de France.Google Scholar
Wittenborn, J. R. (1977) Contrasts in antidepressant medications. British Journal of Clinical Pharmacology, 4, 153S–156S.CrossRefGoogle Scholar
Wittenborn, J. R., Flaherty, C. F., McGough, W. E., Bossanage, K. A. & Nash, R. A. (1976) A comparison of the effect of imipramine, nomifensine and placebo on the psychomotor performance of normal males. Psychopharmacology, 51, 85–90.CrossRefGoogle ScholarPubMed
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