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Persistence of Extra-pyramidal Disorders and Psychiatric Relapse after Withdrawal of Long-Term Phenothiazine Therapy

Published online by Cambridge University Press:  29 January 2018

H. I. Hershon ,
P. F. Kennedy  and
R. J. Mcguire
H. I. Hershon
Affiliation:
Addiction Research Unit, Institute of Psychiatry, Denmark Hill, London S.E.5
P. F. Kennedy
Affiliation:
University Department of Psychiatry, Edinburgh
R. J. Mcguire
Affiliation:
University Department of Psychiatry, Edinburgh
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Extract

It has been said that any drug which is active and produces an effect which is beneficial must also, under similar or different circumstances, have side-effects which are neither beneficial nor desired (Hamilton, 1965). It is the balance between desired and undesired actions which determines the usefulness of any drug. Such a balance varies according to the individual patient's needs. Thus a life-saving drug will be given even if it has serious side effects, while this would not be justifiable for a drug with only a marginally therapeutic effect. Scrutiny of past results may enable clinicians to make finer predictions as to which patient will benefit from a certain drug and which will suffer unacceptable side-effects. Phenothiazines are one group of drugs whose efficacies and dangers have been discussed in this way.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 120 , Issue 554 , January 1972 , pp. 41 - 50
Copyright
Copyright © Royal College of Psychiatrists, 1972 

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