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Performance on Neuropsychological Tests Related to Single Photon Emission Computerised Tomography Findings in Frontotemporal Dementia

Published online by Cambridge University Press:  02 January 2018

Christina I. Elfgren ,
Erik Ryding  and
Ulla Passant
Christina I. Elfgren*
Affiliation:
Department of Psychogeriatrics, University Hospital, Lund, Sweden
Erik Ryding
Affiliation:
Department of Clinical Neurophysiology, University Hospital, Lund, Sweden
Ulla Passant
Affiliation:
Department of Psychogeriatrics, University Hospital, Lund, Sweden
*
Christina I. Elfgren, msc, Clinical Neuropsychologist, Department of Psychogeriatrics, University Hospital, PO Box 638, S-22009 Lund, Sweden
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Abstract

Background

This study examines relations between regional cerebral blood flow (rCBF) and neuropsychological test results, age at onset and duration of disease in patients with frontotemporal-type dementia (FTD).

Method

Sixteen patients with a diagnosis of probable FTD were examined using single photon emission computerised tomography (SPECT) with 99mTc-HMPAO as the tracer. The rCBF of 14 regions of interest relative to cerebellar blood flow was calculated. Psychological tests assessing language, verbal fluency, memory and visuospatial constructive ability were given.

Results

Correlations were demonstrated between a global impairment score and relative blood flow in lateral frontal, medial frontal and left orbital frontal areas. Verbal fluency scores correlated with left lateral frontal medial frontal and left anterior inferior temporal blood flow. No relationships between decrease in CBF and age at onset or duration of disease, or between impaired cognitive function and age at onset or duration of disease, were found.

Conclusions

The present study demonstrates a close coupling between reduced rCBF and specific neuropsychological deficits in FTD.

Type
Papers
Information
The British Journal of Psychiatry , Volume 169 , Issue 4 , October 1996 , pp. 416 - 422
Copyright
Copyright © 1996 The Royal College of Psychiatrists 

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References

Benton, A. L. & Hamsher, K. (1976) Multilingual Aphasia Examination. Iowa City: University of Iowa.Google Scholar
Brun, A. (1993) Frontal lobe degeneration of non-Alzheimer type. Revisited. Dementia, 4, 126–131.Google Scholar
Brun, A., Englund, B., Gustafson, L., et al (1994) Consensus statement – Clinical and neuropathological criteria for frontotemporal dementia. Journal of Neurology, Neurosurgery and Psychiatry, 57, 416–418.Google Scholar
Chase, T. N., Burrows, H. & Mohr, E. (1987) Cortical glucose utilization patterns in primary degenerative dementias of the anterior and posterior type. Archives of Gerontology and Geriatrics, 6, 289–297.CrossRefGoogle ScholarPubMed
Christensen, A.-L. (1974) Luria's Neuropsychological Investigation. Copenhagen: Munksgaard.Google Scholar
Cronholm, B. & Molander, L. (1954) Memory disturbances after electroconvulsive therapy. Conditions six hours after electroshock treatment. Acta Psychiatrica et Neurologica Scandinavica, 32, 280.CrossRefGoogle Scholar
Elfgren, C., Passant, U. & Risberg, J. (1993) Neuropsychological findings in frontal lobe dementia. Dementia, 4, 214–219.Google ScholarPubMed
Elfgren, C., Brun, A., Gustafson, L., et al (1994) Neuropsychological tests as discriminators between dementia of Alzheimer type and frontotemporal dementia. International Journal of Geriatric Psychiatry, 9, 635–642.CrossRefGoogle Scholar
Folstein, M. F., Folstein, S. E. & McHugh, P. R. (1975) “Mini-Mental State”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.CrossRefGoogle ScholarPubMed
Frisoni, G. B., Pizzolato, G., Geroldi, C., et al (1995) Dementia of the frontal type: neuropsychological and (99Tc)-HMPAO SPET features. Journal of Geriatric Psychiatry and Neurology, 8, 42–48.Google Scholar
Gustafson, L. (1992) Frontal lobe degeneration of non-Alzheimer type. In Unusual Dementias, pp. 559–582. Baillière's Clinical Neurology, Vol. 1. London: Baillière Tindall.Google Scholar
Gustafson, L. (1993) Clinical picture of frontal lobe degeneration of non-Alzheimer type. Dementia, 4, 143–148.Google ScholarPubMed
Gustafson, L., Brun, A. & Ingvar, D. H. (1977) Presenile dementia: clinical symptoms, pathoanatomical findings and cerebral blood flow. In Cerebral Vascular Disease (eds Meyer, J. S., Lechner, H. & Reivich, M.), pp. 5–9. Amsterdam: Excerpta Medica.Google Scholar
Holmes, R. A., Chaplin, S. B., Royston, K. G., et al (1985) Cerebral uptake and retention of 99Tcm-hexamethylpropylene amine oxime (99Tcm-HMPAO). Nuclear Medicine Communications, 6, 443–447.CrossRefGoogle Scholar
Husén, T. (1956) CVB-Skalan, Individualtestskala för Vuxna. Lund: Psykologi Förlaget AB.Google Scholar
Jagust, W. J., Reed, B. R., Seab, P. J., et al (1989) Clinical–physiologic correlates of Alzheimer's disease and frontal lobe dementia. American Journal of Physiological Imaging, 4, 89–96.Google ScholarPubMed
Johanson, A. & Hagberg, B. (1989) Psychometric characteristics in patients with frontal lobe degeneration of non-Alzheimer type. Archives of Gerontology and Geriatrics, 8, 129–137.CrossRefGoogle ScholarPubMed
Knopman, M. D., Mastri, A. R., Frey, W. H., et al (1990) Dementia lacking distinctive histological features: a common non-Alzheimer degenerative dementia. Neurology, 40, 251–256.CrossRefGoogle ScholarPubMed
Kretschmann, H. J. & Weirinch, W. (1986) Neuroanatomy and Cranial Computed Tomography. Stuttgart: Thieme Verlag.Google Scholar
Miller, B. K., Cummings, J. L., Villanueva-Meyer, J., et al (1991) Frontal lobe degeneration: clinical neuropsychological and SPECT characteristics. Neurology, 41, 1374–1382.CrossRefGoogle ScholarPubMed
Minoshima, S., Foster, N. L. & Kuhl, D. E. (1994) Posterior cingulate cortex in Alzheimer's disease. Lancet, 344, 895.CrossRefGoogle ScholarPubMed
Neary, D., Snowden, J. S., Shields, R. A., et al (1987) Single photon emission tomography using 99mTc-HM-PAO in the investigation of dementia. Journal of Neurology, Neurosurgery and Psychiatry, 50, 1101–1109.CrossRefGoogle ScholarPubMed
Neary, D., Snowden, J. S., Northern, B., et al (1988) Dementia of frontal lobe type. Journal of Neurology, Neurosurgery and Psychiatry, 51, 353–361.CrossRefGoogle ScholarPubMed
Neary, D., Snowden, J. S. & Mann, D. M. A. (1993) The clinical pathological correlates of lobar atrophy. Dementia, 4, 154–159.Google ScholarPubMed
O'Brien, J. T., Eagger, S., Ghulam, M. S. S., et al (1992) A study of regional cerebral blood flow and cognitive performance in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 55, 1182–1187.CrossRefGoogle ScholarPubMed
Pasquier, F., Lebert, F., Grymonprez, L., et al (1995) Verbal fluency in dementia of frontal lobe type and dementia of Alzheimer type. Journal of Neurology, Neurosurgery and Psychiatry, 58, 81–84.CrossRefGoogle ScholarPubMed
Risberg, J. (1987) Frontal lobe degeneration of non-Alzheimer type. III. Regional cerebral blood flow. Archives of Gerontology and Geriatrics, 6, 225–233.CrossRefGoogle ScholarPubMed
Risberg, J., Passant, U., Warkentin, S., et al (1993) Regional cerebral blood flow in frontal lobe dementia of non-Alzheimer type. Dementia, 4, 186–187.Google ScholarPubMed
Waldemar, G., Hasselbalch, S. G., Andersen, A. R., et al (1991) 99mTc-d, 1-HMPAO and SPECT of the brain in normal aging. Journal of Cerebral Blood Flow and Metabolism, 11, 508–521.CrossRefGoogle Scholar
Wechsler, D. (1958) The Measurement and Appraisal of Adult Intelligence. Baltimore: Williams and Wilkins.Google Scholar
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