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Patterns of Cerebral Blood Flow in Schizophrenia

Published online by Cambridge University Press:  02 January 2018

P. F. Liddle ,
K. J. Friston ,
C. D. Frith ,
S. R. Hirsch ,
T. Jones  and
R. S. J. Frackowiak
P. F. Liddle*
Affiliation:
Department of Psychological Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, DuCane Rd, London W12 0HS
K. J. Friston
Affiliation:
MRC Cyclotron Unit and Charing Cross and Westminster Medical School
C. D. Frith
Affiliation:
MRC Cyclotron Unit
S. R. Hirsch
Affiliation:
Charing Cross and Westminster Medical School
T. Jones
Affiliation:
MRC Cyclotron Unit
R. S. J. Frackowiak
Affiliation:
Royal Postgraduate Medical School and MRC Cyclotron Unit
*
∗Correspondence
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Abstract

Positron emission tomography was used to study the relationship between rCBF and symptom profiles in 30 schizophrenic patients. Factor analysis confirmed that the symptoms segregated into three syndromes – psychomotor poverty, disorganisation, and reality distortion – described previously. Analysis of the correlations between syndrome scores and rCBF revealed that each syndrome was associated with a specific pattern of perfusion in paralimbic and association cortex, and in related subcortical nuclei. The study confirmed predictions that psychomotor poverty and disorganisation are associated with altered perfusion at different loci in the pre-frontal cortex, and reality distortion with altered perfusion in the medial temporal lobe. The perfusion patterns suggest that the abnormalities of brain function underlying each of the three syndromes are not confined to single loci, but involve distributed neuronal networks.

Type
Papers
Information
The British Journal of Psychiatry , Volume 160 , Issue 2 , February 1992 , pp. 179 - 186
Copyright
Copyright © Royal College of Psychiatrists, 1992 

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