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P300 and CT Scan in Patients with Chronic Schizophrenia

Published online by Cambridge University Press:  02 January 2018

A. Romani ,
S. Merello ,
L. Gozzoli ,
F. Zerbi ,
M. Grassi  and
V. Cosi
A. Romani*
Affiliation:
C. Mondino Institute, Neurological Clinic, Pavia, Child Psychiatrist
S. Merello
Affiliation:
San Colombano al Lambro Fatebenefratelli Psychiatric Hospital
L. Gozzoli
Affiliation:
Department of Neuroradiology, Neurological Clinic, Pavia
F. Zerbi
Affiliation:
Neurological Clinic, Pavia
M. Grassi
Affiliation:
Department of Biostatistics, Pavia
V. Cosi
Affiliation:
Neurological Clinic, Pavia
*
Neurological Clinic, Via Palestro 3, 27100-Pavia, Italy
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Extract

Twenty chronic male schizophrenic subjects aged 30–50 years were examined by an auditory event-related potential procedure for the evaluation of the P300 component, a CT scan and a neuropsychological test battery. The P300 latency was increased and its amplitude was reduced. CT scan measures showed lateral and third ventricle enlargement, and there was a global neuropsychological impairment. Poor neuropsychological performances were consistently associated with delayed P300 latencies, but not with CT scan measures. Ventricular enlargement was more pronounced among subjects with a negative family history for major psychiatric disorders.

Type
Papers
Information
The British Journal of Psychiatry , Volume 151 , Issue 4 , October 1987 , pp. 506 - 513
Copyright
Copyright © Royal College of Psychiatrists, 1987 

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