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Oral olanzapine versus oral haloperidol in the maintenance treatment of schizophrenia and related psychoses

Published online by Cambridge University Press:  03 January 2018

Pierre V. Tran ,
Mary Anne Dellva ,
Gary D. Tollefson ,
Anita L. Wentley  and
Charles M. Beasley Jr
Pierre V. Tran*
Affiliation:
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, USA
Mary Anne Dellva
Affiliation:
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, USA
Gary D. Tollefson
Affiliation:
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, USA
Anita L. Wentley
Affiliation:
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, USA
Charles M. Beasley Jr
Affiliation:
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, USA
*
Dr Pierre V. Tran, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0538, Indianapolis, IN 46285. Tel: 317-276-4491. Fax: 317-277-7839
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Abstract

Background

Three studies compared olanzapine and haloperidol given orally in maintenance therapy for schizophrenia and related psychoses.

Method

Data were from double-blind extensions of acute studies. The subjects met criteria for schizophrenia, schizophreniform disorder or schizoaffective disorder. Subjects had responded to acute therapy (Brief Psychiatric Rating Scale total score decreased $ 40% from baseline (Studies 1, 2, and 3) or was $ 18 (Studies I and 2)) and were out-patients at their last acute phase visit. Relapse was defined as hospitalisation for psychopathology. Subjects treated with olanzapine in the three studies were pooled to form the olanzapine group and subjects treated with haloperidol were pooled to form the haloperidol group.

Results

Olanzapine-treated subjects experienced less relapse (P=0.034). The Kaplan-Meier estimated one-year risk of relapse was 19.7% with olanzapine and 28% with haloperidol.

Conclusion

Olanzapine was superior to haloperidol in the maintenance therapy of schizophrenia and related psychoses.

Type
Papers
Information
The British Journal of Psychiatry , Volume 172 , Issue 6 , June 1998 , pp. 499 - 505
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

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Footnotes

Declaration of interest

This work was sponsored by Eli Lilly and Company.

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