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The Onset and Rate of the Antidepressant Effect of Electroconvulsive Therapy

A Neglected Topic of Research

Published online by Cambridge University Press:  02 January 2018

Allan I. F. Scott*
Affiliation:
Andrew Duncan Clinic, Royal Edinburgh Hospital, Morningside Terrace, Edinburgh EH10 5HF
Lawrence J. Whalley
Affiliation:
University Department of Mental Health, Foresterhill, Aberdeen AB9 2ZD
*
Correspondence

Extract

This annotation is concerned with how soon and at what rate antidepressant effects become apparent over a course of electroconvulsive therapy (ECT). The first question is of importance in the design and interpretation of biological studies of the mode of action of ECT. The second question is of practical interest to the treating psychiatrist when we ask how the speed of recovery is influenced by what the psychiatrist prescribes, that is, the number and frequency of treatments. These questions are little better answered now than 20 years ago. This may come as a surprise to many readers, who have been advised to use ECT when “seeking rapid improvement” in depressive disorders (ECT Sub-Committee of the Research Committee of the Royal College of Psychiatrists, 1989). This lack of progress is attributable to a dearth of appropriately designed ECT studies.

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Annotation
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Abrams, R. (1982) Clinical prediction of ECT response in depressed patients. Psychopharmacology Bulletin, 18, 4850.Google ScholarPubMed
Abrams, R. (1986) Is unilateral electroconvulsive therapy really the treatment of choice in endogenous depression? Annals of the New York Academy of Sciences, 462, 5055.CrossRefGoogle ScholarPubMed
Abrams, R. (1988) Electroconvulsive Therapy, pp. 9598. Oxford: Oxford University Press.Google Scholar
American Psychiatric Association Task Force on Electroconvulsive Therapy (1990) The Practice of Electroconvulsive Therapy: Recommendations for Treatment, Training and Privileging. Washington, DC: APA.Google Scholar
Avery, D. & Winokur, G. (1977) The efficacy of electroconvulsive therapy and antidepressants in depression. Biological Psychiatry, 12, 507523.Google ScholarPubMed
Barton, J. L. (1977) ECT in depression: the evidence of controlled studies. Biological Psychiatry, 12, 687695.Google ScholarPubMed
Barton, J. L., Mehta, S. & Snaith, R. P. (1973) The prophylactic value of ECT in depressive illness. Acta Psychiatrica Scandinavica, 49, 386392.CrossRefGoogle ScholarPubMed
Blachly, P. H. & Gowing, D. (1966) Multiple monitored electroconvulsive treatment. Comprehensive Psychiatry, 7, 100109.CrossRefGoogle Scholar
Black, D. W., Winokur, G. & Nasrallah, A. (1989) Illness duration and acute response in major depression. Convulsive Therapy, 5, 338343.Google ScholarPubMed
Browning, S. M. & Cowen, P. J. (1986) Changes in mood, appetite and psychomotor retardation in depressed patients given ECT. British Journal of Psychiatry, 149, 371373.CrossRefGoogle ScholarPubMed
Clare, A. (1980) Psychiatry in Dissent, p. 278. Cambridge: Tavistock.Google Scholar
Crow, T. J., Deakin, J. F. W., Johnstone, E. C., et al (1984) The Northwick Park ECT trial. Predictors of response to real and simulated ECT. British Journal of Psychiatry, 144, 227237.Google Scholar
Crow, T. J., & Johnstone, E. C. (1986) Controlled trials of electroconvulsive therapy. Annals of the New York Academy of Science, 462, 1229.CrossRefGoogle ScholarPubMed
Daniel, W. F. (1983) ECT seizure duration and alleviation of depression. British Journal of Psychiatry, 143, 523.CrossRefGoogle ScholarPubMed
Dykes, S. R. (1988) Process of Change in Mood and Cognition During a Course of ECT. MPhil Thesis, University of Edinburgh.Google Scholar
ECT Sub-Committee of the Research Committee of the Royal College of Psychiatrists (1989) The Practical Administration of Electroconvulsive Therapy. London: Gaskell.Google Scholar
Fink, M. (1979) Convulsive Therapy. New York: Raven Press.Google Scholar
Forrest, A. D. (1973) Physical and pharmacological methods of treatment. In The Companion to Psychiatric Studies, vol. 2 (ed. Forrest, A.), pp. 391412. Edinburgh: Churchill Livingstone.Google Scholar
Gelder, M., Gath, R. & Mayou, R. (1989) Oxford Textbook of Psychiatry, p. 688. Oxford: Oxford University Press.Google Scholar
Grahame-Smith, D. G., Green, A. R. & Costain, D. W. (1978) Mechanism of the antidepressant action of electroconvulsive therapy. Lancet, i, 254257.CrossRefGoogle Scholar
Green, A. R. & Nutt, D. J. (1987) Psychopharmacology of repeated seizures: possible relevance to the mechanism of action of ECT. In New Directions in Behavioural Pharmacology, vol. 19 (eds Iversen, L. et al), pp. 375419. London: Plenum Press.Google Scholar
Gregory, S., Shawcross, C. R. & Gill, D. (1985) The Nottingham ECT study. British Journal of Psychiatry, 146, 520524.CrossRefGoogle ScholarPubMed
Hill, P., Murray, R. & Thorley, A. (1986) Essentials of Post-Graduate Psychiatry, p. 677. London: Grune & Stratten.Google Scholar
Kaplan, H. I. & Sadock, B. J. (1989) Comprehensive Textbook of Psychiatry, pp. 16701678. London: Williams & Wilkins.Google Scholar
Katz, M. M., Koslow, S. H., Maas, J. W., et al (1987) The timing, specificity and clinical prediction of tricyclic drug effects in depression. Psychological Medicine, 19, 297309.CrossRefGoogle Scholar
Kendell, R. E. & Zealley, A. K. (1988) Companion to Psychiatric Studies, pp. 709720. Edinburgh: Churchill Livingstone.Google Scholar
Kety, S. (1974) Biochemical and neurochemical effects of electroconvulsive shock. In Psychobiology of Convulsive Therapy (eds Fink, M., Kety, S., McGaugh, J., et al), pp. 285294. Washington, DC: V. H. Winston.Google Scholar
Kiloh, L. G., Smith, J. S. & Johnson, G. F. (1988) Physical Treatments in Psychiatry, pp. 205252. Edinburgh: Blackwell Scientific.Google Scholar
Lerer, B., Weiner, R. D. & Belmaker, R. H. (1984) ECT: Basic Mechanisms. London: John Libbey.Google Scholar
Lerer, B., & Shapira, B. (1986) Optimum frequency of ECT: implications for practice and research. Convulsive Therapy, 2, 141144.Google Scholar
Lerer, B., & Shapira, B. & Calev, A. (1991) Optimising ECT: schedule of administration. Biological Psychiatry, 29, 118S.Google Scholar
McAllister, D. A., Perri, M. G., Jordan, R. C., et al (1987) Effects of ECT given two versus three times weekly. Psychiatry Research, 21, 6369.CrossRefGoogle Scholar
Montgomery, S. A. & Åsberg, M. (1979) A new depression scale designed to be sensitive to the change. British Journal of Psychiatry, 134, 382389.CrossRefGoogle Scholar
National Advisory Mental Health Council (1988) Approaching the 21st Century: Opportunities for NIMH Neuroscience Research. DHHS Publication No: 88-1580. Maryland: US Department of Health and Human Services.Google Scholar
Pande, A. C., Krugler, T., Haskett, R. F., et al (1988) Predictors of response to ECT in major depressive disorder. Biological Psychiatry, 24, 9193.CrossRefGoogle Scholar
Pande, A. C., Grunhaus, L. J., Haskett, R. F., et al (1990) Electroconvulsive therapy in delusional and non-delusional depressive disorder. Journal of Affective Disorders, 19, 215219.CrossRefGoogle ScholarPubMed
Perris, C. (1966) A study of bipolar and unipolar recurrent depressive psychosis. Acta Psychiatrica Scandinavica (suppl. 194), 153165.CrossRefGoogle Scholar
Pettinati, H. M. & Nilsen, S. (1985) Missed and brief seizures during ECT. Biological Psychiatry, 20, 506514.CrossRefGoogle ScholarPubMed
Pettinati, H. M., Stephens, S. M., Willis, K. M., et al (1990) Evidence for less improvement in depression in patients taking benzodiazepines during unilateral ECT. American Journal of Psychiatry, 147, 10291035.Google ScholarPubMed
Pippard, J. & Ellam, L. (1981) Electroconvulsive Treatment in Great Britain. London: Gaskell.CrossRefGoogle ScholarPubMed
Post, R. M., Uhde, T. W., Rubinow, D. R., et al (1987) Differential time course for antidepressant effects after sleep deprivation, ECT, and carbamazepine: clinical and theoretical implications. Psychiatry Research, 22, 1119.CrossRefGoogle ScholarPubMed
Price, T. R. P., Mackenzie, T. B., Ticker, G. J., et al (1978) The dose-response ratio in electroconvulsive therapy. Archives of General Psychiatry, 35, 11311136.CrossRefGoogle ScholarPubMed
Prien, R. F., Carpenter, L. L. & Kupfer, D. J. (1991) The definition and operational criteria for treatment outcome of major depressive disorder. Archives of General Psychiatry, 486, 796800.CrossRefGoogle Scholar
Prudic, C. J., Sackheim, H. A. & Devanand, D. P. (1990) Medication resistance and clinical response to ECT. Psychiatry Research, 31, 287296.CrossRefGoogle Scholar
Rich, C. L. & Black, N. A. (1985) The efficacy of ECT: II. Correlation of specific treatment variables to response rate in unilateral ECT. Psychiatry Research, 16, 147154.CrossRefGoogle ScholarPubMed
Roemer, R. A., Dubin, W. R., Jaffe, R., et al (1990) An efficacy study of single-versus double-seizure induction with ECT in major depression. Journal of Clinical Psychiatry, 51, 473478.Google ScholarPubMed
Sackeim, H. A., Decina, P., Kanzler, M., et al (1987) Effects of electrode placement on the efficacy of titrated low-dose ECT. American Journal of Psychiatry, 144, 14491455.Google ScholarPubMed
Sargent, W. & Slater, E. (1944) An Introduction to Physical Methods of Treatment in Psychiatry. Edinburgh: Livingstone.Google Scholar
Scott, A. I. F., Whalley, L. J., Bennie, J., et al (1986) Oestrogen-stimulated neurophysin and outcome after electroconvulsive therapy. Lancet, i, 14111414.CrossRefGoogle Scholar
Scott, A. I. F., Whalley, L. J., & Legros, J.-J. (1989) Treatment outcome, seizure and duration and the neurophysin response to ECT. Biological Psychiatry, 25, 585597.CrossRefGoogle ScholarPubMed
Scott, A. I. F., Shering, P. A., Legros, J.-J., et al (1991) Recovery from depressive illness is not associated with altered neurophysin release. Psychiatry Research, 36, 6573.CrossRefGoogle Scholar
Slater, E. & Roth, M. (1969) Clinical Psychiatry (3rd edn), pp. 232236. London: Baillière, Tindall & Cassell.Google Scholar
Small, J. K., Small, I. F. & Milstein, Z. (1978) Electrophysiology of EST. In Psychopharmacology: A Generation of Progress (eds Lipton, M. A. et al). New York: Raven Press.Google Scholar
Smith, J. K., Williams, K., Glue, P., et al (1990) Oxytocin responses to ECT - relationship to treatment outcome. Abstracts of Proceedings of Meetings of the Royal College of Psychiatrists. Psychiatric Bulletin (suppl. 3), p. 61.Google Scholar
Stromgren, L. S. (1975) Therapeutic results in brief interval unilateral ECT. Acta Psychiatrica Scandinavica, 52, 246255.CrossRefGoogle ScholarPubMed
Whalley, L. J., Eagles, J. M., Bowler, G. M., et al (1987) Selective effects of ECT on hypothalamic pituitary activity. Psychological Medicine, 17, 312328.CrossRefGoogle ScholarPubMed
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