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On the Transmission of Dementia: A personal view of the slow virus problem

Published online by Cambridge University Press:  29 January 2018

J. A. N. Corsellis
J. A. N. Corsellis*
Affiliation:
Institute of Psychiatry, De Crespigny Park, London SE5 8AF
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Extract

I came across Creutzfeldt-Jakob disease within a few weeks of starting work in the neuropathological laboratories at the Maudsley Hospital. The time was the 1940's, and Alfred Meyer, who had known both Creutzfeldt and Jakob in Germany, had already published his study on the possible link between amyotrophic lateral sclerosis and Creutzfeldt-Jakob disease (or spastic pseudosclerosis of Jakob as it was then called). Meyer's interest in the condition was therefore well known to British psychiatrists and neurologists, and patients who were thought to be suffering from this illness were referred to him. Routine post-mortem examinations would be duly carried out, perhaps by the psychiatric staff, and the brain, sometimes with the spinal cord, would be hardened in formalin and sent in a parcel to the Maudsley laboratories.

Type
Papers
Information
The British Journal of Psychiatry , Volume 134 , Issue 6 , June 1979 , pp. 553 - 559
Copyright
Copyright © Royal College of Psychiatrists, 1979 

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References

Alter, M., Neugut, R. & Kahana, E. (1978) Familial aggregates of Creutzfeldt-Jakob disease (abstract). Neurology (New York), 28, 353.Google Scholar
Beck, E., Daniel, P. M., Alpers, M., Gajdusek, D. C. & Gibbs, C. J. Jr. (1966) Experimental kuru in chimpanzees: a pathological report. Lancet, ii, 1056–9.Google Scholar
Beck, E., Daniel, P. M., Matthews, W. B., Stevens, D. L., Alpers, M. P., Asher, D. M., Gajdusek, D. C. & Gibbs, C. J. Jr. (1969) Creutzfeldt-Jakob disease. The neuropathology of a transmission experiment. Brain, 92, 699–716.CrossRefGoogle ScholarPubMed
Bernoulli, C., Siegfried, J., Baumgartner, G., Regli, F., Rabinowicz, T., Gajdusek, D. C. & Gibbs, C. J. Jr. (1977) Danger of accidental person-to-person transmission of Creutzfeldt-Jakob disease by surgery. Lancet, i, 478–9.Google Scholar
Creutzfeldt, H. G. (1921) Über eine eigenartige herdförmige Erkrankung des Zentralnervensystems. In Histologische und histopathologische Arbeiten über die Grosshirnrinde (eds Nissl und Alzheimer), Suppl. 6, 1–48.Google Scholar
Duffy, P., Wolf, J., Collins, G., DeVoe, A. G., Streeten, B. & Cowen, D. (1974) Possible person-to-person transmission of Creutzfeldt-Jakob disease. New England Journal of Medicine, 299, 692–3.Google Scholar
Gajdusek, D. C. & Zigas, V. (1957) Degenerative disease of the central nervous system in New Guinea. The endemic occurrence of ‘Kuru’ in the native population. New England Journal of Medicine, 257, 974–8.CrossRefGoogle ScholarPubMed
Gajdusek, D. C., Gibbs, C. J. Jr. & Alpers, M. (1966) Experimental transmission of a kuru-like syndrome to chimpanzees. Nature, 209, 794–6.CrossRefGoogle ScholarPubMed
Gajdusek, D. C. (1972) Slow infections: Spongiform virus encephalopathies. In Host-Virus Reactions with Special Reference to Persistent Agents (ed. G. Dick). London: Journal of Clinical Pathology (pp 78–83).Google Scholar
Gajdusek, D. C., Gibbs, C. J. Jr., Asher, D. M., Brown, P., Diwan, A., Hoffman, P., Nemo, G., Rohwer, R. & White, L. (1977) Precautions in medical care of and in handling materials from patients with transmissible virus dementia (Creutzfeldt-Jakob disease). New England Journal of Medicine, 297, 1253–8.CrossRefGoogle ScholarPubMed
Garzuly, F., Jellinger, K. & Pilz, P. (1971) Subakute spongiöse Encephalopathie (Jakob-Creutzfeldt-Syndrom). Klinischmorphologische Analyse von 9 Fällen. Archiv für Psychiatric und Nervenkrankheiten, 214, 207–27.CrossRefGoogle Scholar
Gibbs, C. J. Jr., Gajdusek, D. C., Asher, D. M., Alpers, M. P., Beck, E., Daniel, P. M. & Matthews, W. B. (1968) Creutzfeldt-Jakob disease (spongiform encephalopathy) : Transmission to the chimpanzee. Science, 161, 388–9.CrossRefGoogle Scholar
Grabow, J. D., Campbell, R. J., Okazaki, H., Schut, L., Zollman, P. E. & Kurland, L. T. (1976) A transmissible subacute spongiform encephalopathy in a visitor to the Eastern Highlands of New Guinea. Brain, 99, 637–58.CrossRefGoogle Scholar
Hadlow, W. J. (1959) Scrapie and kuru. Lancet, 2, 289–90.Google Scholar
Howie, J. (1978) (Chairman) Code of Practive for the Prevention of Infection in Clinical Laboratories and Postmortem Rooms. London: HMSO.Google Scholar
Jakob, A. (1921) Über eigenartige Erkrankungen des Zentralnervensystems mit bemerkenswertem anatomischem Befunde. Zeitschrift für die gesamte Neurologic und Psychiatric, 64, 147–228.CrossRefGoogle Scholar
Kahana, E., Alter, M., Braham, J. & Sofer, D. (1974) Creutzfeldt-Jakob disease: focus among Libyan Jews in Israel. Science, 183, 90–1.CrossRefGoogle ScholarPubMed
Kirschbaum, W. R. (1968) In Jakob-Creutzfeldt Disease. New York: Elsevier.Google Scholar
Klatzo, I., Gajdusek, D. C. & Zigas, V. (1959) Pathology of kuru. Laboratory Investigation, 8, 799–847.Google ScholarPubMed
Masters, C. L., Harris, J. O., Gajdusek, D. C., Gibbs, C. J. Jr., Bernoulli, C. & Asher, D. M. (1979) Creutzfeldt-Jakob disease: patterns of world-wide occurrence and the significance of familial and sporadic clustering. Annals of Neurology, 5, 177–88.CrossRefGoogle Scholar
Matthews, W. B. (1975) Epidemiology of Creutzfeldt-Jakob disease in England and Wales. Journal of Neurology, Neurosurgery and Psychiatry, 38, 210–13.CrossRefGoogle ScholarPubMed
Meyer, A. (1929) Über eine der amyotrophischen Lateralsclerose nahestehende Erkrankung mit psychischen Störungen. Zugleich ein Beitrag zur Frage der spastischen Pseudosclerose (A. Jakob). Zeitschrift für die gesamte Neurologic und Psychiatric, 121, 107–38.Google Scholar
Rewcastle, N. B., Gibbs, C. J. Jr. & Gadjusek, D. C. (1978) Transmission of familial Alzheimer's disease to primates. Abstracts of the VIIIth International Congress of Neuropathology, 679.Google Scholar
Traub, R., Gajdusek, D. C. & Gibbs, C. J. Jr. (1977) Transmissible virus dementia: the relation of transmissible spongiform encephalopathy to Creutzfeldt-Jakob disease. In Aging and Dementia. New York: Spectrum Publications, Inc. (pp 91–172).Google Scholar
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