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Olanzapine versus haloperidol in the treatment of schizoaffective disorder

Acute and long-term therapy

Published online by Cambridge University Press:  02 January 2018

Pierre V. Tran ,
Gary D. Tollefson ,
Todd M. Sanger ,
Yili Lu ,
Paul H. Berg  and
Charles M. Beasley Jr
Pierre V. Tran*
Affiliation:
Psychopharmacology Division, Lilly Research Laboratories, Indianapolis, IN, USA
Gary D. Tollefson
Affiliation:
Psychopharmacology Division, Lilly Research Laboratories, Indianapolis, IN, USA
Todd M. Sanger
Affiliation:
Psychopharmacology Division, Lilly Research Laboratories, Indianapolis, IN, USA
Yili Lu
Affiliation:
Psychopharmacology Division, Lilly Research Laboratories, Indianapolis, IN, USA
Paul H. Berg
Affiliation:
Psychopharmacology Division, Lilly Research Laboratories, Indianapolis, IN, USA
Charles M. Beasley Jr
Affiliation:
Psychopharmacology Division, Lilly Research Laboratories, Indianapolis, IN, USA
*
Pierre V. Tran, MD, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0538, Indianapolis, IN 46285. Tel: (317)27: (317) 276–4491; Fax: (317)277–7893
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Abstract

Background

The effectiveness of antipsychotic monotherapy in schizoaffective disorder is limited, and further constrained by safety concerns.

Aims

We aimed to compare the efficacy, tolerability and safety profile of the new pharmaceutical, olanzapine, with haloperidol.

Method

Data were assessed from 300 DSM – III – R schizoaffective subjects from a larger double-blind prospective international study. Subjects were randomly allocated to six weeks of olanzapine (5–20 mg) or haloperidol (5–20 mg) treatment; responders were followed for up to one year of double-blind, long-term maintenance therapy.

Results

Olanzapine-treated patients achieved a statistically significant greater improvement than haloperidol-treated patients on overall measures of efficacy, including clinical response. Significantly fewer olanzapine patients left the study early, and fewer adverse events were observed among those receiving olanzapine. During maintenance, olanzapine-treated patients continued to experience additional improvement, with fewer EPS but more weight gain than those on haloperidol.

Conclusions

Olanzapine demonstrated substantial advantages over the conventional antipsychotic haloperidol in the management of schizoaffective disorder.

Type
Papers
Information
The British Journal of Psychiatry , Volume 174 , Issue 1 , January 1999 , pp. 15 - 22
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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Footnotes

Declaration of interest

Sponsored by Eli Lilly and Company.

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