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Obstetric Complications and Schizophrenia a Case-Control Study

Published online by Cambridge University Press:  02 January 2018

Flavia Günther-Genta ,
Pierre Bovet  and
Patrick Hohlfeld
Flavia Günther-Genta
Affiliation:
University Department of Adult Psychiatry (DAMPS), Lausanne, Switzerland
Pierre Bovet*
Affiliation:
University Department of Adult Psychiatry (PPU A), Lausanne
Patrick Hohlfeld
Affiliation:
Department of Gynecology & Obstetrics (CHUV), Lausanne
*
∗PPU A, 18, av. de Sévelin, CH-1004, Lausanne, Switzerland
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Abstract

Schizophrenics have been repeatedly found to experience more obstetric complications (OCs) at birth. The meaning of such a finding is debated, and the aim of this study is to contribute to the understanding of OCs' aetiological role in schizophrenia. We compared a group of schizophrenic patients with their siblings and controls, on the basis of obstetric files stemming from the same University Hospital Maternity Ward. Schizophrenic patients had more frequent umbilical cord complications and atypical presentations, as well as higher scores on a scale measuring OCs linked to possible neonatal asphyxia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 2 , February 1994 , pp. 165 - 170
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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References

Andreasen, N. C., Nasrallah, H. A., Dunn, V., et al (1986) Structural abnormalities in the frontal system in schizophrenia. Archives of General Psychiatry, 43, 136–144.10.1001/archpsyc.1986.01800020042006Google Scholar
Andreasen, N. C., Ehrardt, J. C., Crossett, J. H. W., et al (1987) Hat size in schizophrenia. Archives of General Psychiatry, 44, 674–676.Google Scholar
Barr, C. E., Mednick, S. A. & Munk-Jorgensen, P. (1990) Exposure to influenza epidemics during gestation and adult schizophrenia. A 40-year study. Archives of General Psychiatry, 47, 869–874.10.1001/archpsyc.1990.01810210077012CrossRefGoogle ScholarPubMed
Blennow, G. & McNeil, T. F. (1991) Neurological deviations in newborns at psychiatric high risk. Acta Psychiatrica Scandinavica, 84, 179–184.10.1111/j.1600-0447.1991.tb03125.xGoogle Scholar
Bleuler, E. (1911) Dementia praecox oder Gruppe der Schizophrenien. In Handbuch der Psychiatrie. Spezieller Teil, 4. Abteilung, 1. Hälfte (ed. Aschaffenburg, G.). Leipzig: Deuticke. Trans, by Zinkin, J. (1950) Dementia Praecox or the Group of Schizophrenias. New York: International University Press.Google Scholar
Bleuler, E. & Jung, C. G. (1908) Komplexe und Krankheitsurachen bei Dementia praecox. Zentralblatt für Nervenheilkunde und Psychiatrie, 31, 220–227.Google Scholar
Bleuler, M. (1972) Die schizophrenen Geistestörungen im Lichte langjähriger Kranken- und Familiengeschichten. Stuttgart: Thieme. Trans. by Clemens, S. M. (1978) The Schizophrenic Disorders. Long-term Patient and Family Studies. New Haven: Yale University Press.Google Scholar
Bovet, P. (1990) Pathologie du deuil dans la schizophrénie: une hypothèse étiopathogénique. Entrevues, 17, 3–18.Google Scholar
Cannon, T. D., Mednick, S. A. & Parnas, J. (1989) Genetic and perinatal determinants of structural brain deficits in schizophrenia. Archives of General Psychiatry, 46, 883–889.10.1001/archpsyc.1989.01810100025005CrossRefGoogle ScholarPubMed
Ciompi, L. (1980) Three lectures on schizophrenia. The natural history of schizophrenia in the long term. British Journal of Psychiatry, 136, 413–420.10.1192/bjp.136.5.413Google Scholar
Ciompi, L. (1988) Learning from outcome studies. Toward a comprehensive biological-psychosocial understanding of schizophrenia. Schizophrenia Research, 1, 373–384.10.1016/0920-9964(88)90018-7CrossRefGoogle Scholar
Ciompi, L. & Müller, C. (1976) Lebensweg und Alter der Schizophrenen. Eine katamnestische Langzeitstudie bis ins Senium. Berlin: Springer.10.1007/978-3-662-01606-0Google Scholar
DeLisi, L. E. & Goldin, L. R. (1987) Hat size in schizophrenia. Archives of General Psychiatry, 44, 672–673.10.1001/archpsyc.1987.01800190092015Google Scholar
DeLisi, L. E. Dauphinais, I. D. & Gershon, E. S. (1988) Perinatal complications and reduced size of brain limbic structures in familial schizophrenia. Schizophrenia Bulletin, 14, 185–191.10.1093/schbul/14.2.185Google Scholar
Done, D. J., Johnstone, E. C., Frith, C. D., et al (1991) Complications of pregnancy and delivery in relation to psychosis in adult life: data from the British perinatal mortality survey sample. British Medical Journal, 302, 1576–1580.10.1136/bmj.302.6792.1576CrossRefGoogle ScholarPubMed
Eagles, J. M., Gibson, I., Brenner, M. H., et al (1990) Obstetric complications in DSM–III schizophrenics and their siblings. Lancet, 335, 1139–1141.10.1016/0140-6736(90)91136-XCrossRefGoogle ScholarPubMed
Goodman, R. (1988a) Are complications of pregnancy and birth causes of schizophrenia? Developmental Medicine and Child Neurology, 30, 391–406.10.1111/j.1469-8749.1988.tb14567.xCrossRefGoogle ScholarPubMed
Goodman, R. (1988b) Obstetric complications and schizophrenia. British Journal of Psychiatry, 153, 850.10.1192/bjp.153.6.850bGoogle Scholar
Jacobsen, B. & Kinney, D. K. (1980) Perinatal complications in adopted and non-adopted schizophrenics and their controls. Acta Psychiatrica Scandinavica, 62 (suppl.), 337–346.10.1111/j.1600-0447.1980.tb07709.xCrossRefGoogle Scholar
Jones, G. H. & Lewis, J. E. (1991) Head circumference in elderly long-stay patients with schizophrenia. British Journal of Psychiatry, 159, 435–438.10.1192/bjp.159.3.435Google Scholar
Kerwin, R. & Woodhouse, W. (1991) Complications of pregnancy and delivery and psychosis in adult life. British Medical Journal, 303, 188.10.1136/bmj.303.6795.188-bGoogle Scholar
Lewis, S. W. (1989) Congenital risk factors for schizophrenia. Psychological Medicine, 19, 5–13.10.1017/S0033291700010977Google Scholar
Lewis, S. W. & Murray, R. M. (1987) Obstetric complications, neurodevelopmental deviance and risk of schizophrenia. Journal of Psychiatric Research, 21, 413–422.10.1016/0022-3956(87)90088-4Google Scholar
Lewis, S. W. Owen, M. J. & Murray, R. M. (1989) Obstetric complications and schizophrenia: methodology and mechanisms. In Schizophrenia: Scientific Progress (eds S. C. Schulz & C. A. Tamminga), pp. 56–68. New York: Oxford University Press.Google Scholar
Lyon, M., Barr, C. E., Cannon, T. D., et al (1989) Fetal neural development and schizophrenia. Schizophrenia Bulletin, 15, 149–161.10.1093/schbul/15.1.149Google Scholar
McNeil, T. F. (1987) Perinatal influences in the development of schizophrenia. In Biological Perspectives of Schizophrenia (eds H. Helmchen & F. A. Henn), pp. 125–138. London: Wiley.Google Scholar
McNeil, T. F. & Kaij, L. (1978) Obstetric factors in the development of schizophrenia: complications in the births of preschizophrenics and in reproduction by schizophrenic parents. In The Nature of Schizophrenia. New Approaches to Research and Treatment (eds L. C. Wynne, R. L. Cromwell & S. Matthysee), pp. 401–429. New York: Wiley.Google Scholar
Mednick, S. A., Machón, R. A. & Huttunen, M. O. (1989) Disturbances of fetal neurodevelopment and adult schizophrenia. In Schizophrenia: a Scientific Focus (ed. Schulz, S.C.), pp. 69–77. New York: Oxford University Press.Google Scholar
Meehl, P. E. (1962) Schizotaxia, schizotypy, schizophrenia. American Psychologist, 17, 827–838.10.1037/h0041029CrossRefGoogle Scholar
Meehl, P. E. (1989) Schizotaxia revisited. Archives of General Psychiatry, 46, 935–944.10.1001/archpsyc.1989.01810100077015CrossRefGoogle ScholarPubMed
Murray, R. M. & Lewis, S. W. (1987) Is schizophrenia a neurodevelopmental disorder? British Medical Journal, 295, 681–682.10.1136/bmj.295.6600.681Google Scholar
Murray, R. M. Reveley, A. M. & Lewis, S. W. (1988) Family history, obstetric complications and cerebral abnormality in schizophrenia. In Handbook of Schizophrenia, vol. 3: Nosology, Epidemiology and Genetics (eds M. T. Tsuang & J. C. Simpson), pp. 563–577. Amsterdam: Elsevier.Google Scholar
Nimgaonkar, V. L., Wessely, S. & Murray, R. M. (1988) Prevalence of familiality, obstetric complications, and structural brain damage in schizophrenic patients. British Journal of Psychiatry, 153, 191–197.10.1192/bjp.153.2.191Google Scholar
Nuechterlein, K. H. (1987) Vulnerability models for schizophrenia: state of the art. In Search for the Causes of Schizophrenia (eds H. Häfner, W. F. Gattaz & W. Janzarik), pp. 300–316. Berlin: Springer.Google Scholar
O'Callaghan, E., Larkin, C., Kinsella, A., et al (1990a) Obstetric complications, the putative familial-sporadic distribution and tardive dyskinesia in schizophrenia. British Journal of Psychiatry, 157, 578–584.10.1192/bjp.157.4.578Google Scholar
O'Callaghan, E., Larkin, C., & Waddington, J. L. (1990b) Obstetric complications in schizophrenia: validity of maternal recall. Psychological Medicine, 20, 89–94.10.1017/S0033291700013258Google Scholar
O'Callaghan, E., Sham, P., Takei, N., et al (1991) Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic. Lancet, 337, 1248–1250.10.1016/0140-6736(91)92919-SCrossRefGoogle ScholarPubMed
O'Callaghan, E., Gibson, T., Colohan, H. A., et al (1992) Risk of schizophrenia in adults born after obstetric complications and their association with early onset of illness: a controlled study. British Medical Journal, 305, 1256–1259.10.1136/bmj.305.6864.1256Google Scholar
Owen, M. J., Lewis, S. W. & Murray, R. M. (1988) Obstetric complications and schizophrenia: a computed tomographic study. Psychological Medicine, 18, 331–339.10.1017/S003329170000787XGoogle Scholar
Parnas, J. (1990) Schizophrenia: etiological factors in the light of longitudinal high risk research. In Etiology of Mental Disorders (eds E. Kringlen, N. J. Larrik & S. Torgersen), pp. 49–61. Oslo: Department of Psychiatry.Google Scholar
Parnas, J. Schulsinger, F., Teasdale, T. W., et al (1982) Perinatal complications and clinical outcome within the schizophrenia spectrum. British Journal of Psychiatry, 40, 416–420.10.1192/bjp.140.4.416CrossRefGoogle Scholar
Pasamanick, B., Rogers, M. E. & Lilienfeld, A. M. (1956) Pregnancy experience and the development of behaviour disorder in children. American Journal of Psychiatry, 112, 613–618.10.1176/ajp.112.8.613Google Scholar
Pasamanick, B., & Knobloch, H. (1960) Brain damage and reproductive casualty. American Journal of Orthopsychiatry, 30, 398–405.10.1111/j.1939-0025.1960.tb02341.xGoogle Scholar
Pearlson, G. D., Garbacz, D. J., Moberg, P. J., et al (1985) Symptomatic, familial, perinatal and social correlates of computerised axial tomography (CAT) changes in schizophrenics and bipolars. Journal of Nervous and Mental Disease, 173, 42–50.10.1097/00005053-198501000-00007CrossRefGoogle ScholarPubMed
Reveley, A. M., Reveley, M. A. & Murray, R. M. (1984) Cerebral ventricular enlargement in non-genetic schizophrenia: a controlled twin study. British Journal of Psychiatry, 144, 89–93.10.1192/bjp.144.1.89Google Scholar
Reveley, M. A. & Reveley, A. M. (1987) Hat size in schizophrenia. Archives of General Psychiatry, 44, 673–674.10.1001/archpsyc.1987.01800190093017Google Scholar
Shields, J. & Gottesmann, I. I. (1977) Obstetric complications and twin studies of schizophrenia: clarifications and affirmations. Schizophrenia Bulletin, 3, 351–354.10.1093/schbul/3.3.351Google Scholar
Silverton, L., Mednick, S. A., Schulsinger, F., et al (1988) Genetic risk for schizophrenia, birthweight, and cerebral ventricular enlargement. Journal of Abnormal Psychology, 97, 496–498.10.1037/0021-843X.97.4.496Google Scholar
Spellacy, W. N., Gravem, H. & Fich, R. O. (1966) The umbilical cord complications of true knots, nuchal coils and cord around the body. Report from the collaborative study of cerebral palsy. American Journal of Obstetrics and Gynecology, 94, 1136–1142.10.1016/0002-9378(66)90777-0Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders, 3rd edition. New York: State Psychiatric Institute.Google Scholar
Stevens, J. R. & Waldmon, I. N. (1987) Hat size in schizophrenia. Archives of General Psychiatry, 44, 673.10.1001/archpsyc.1987.01800190093016Google Scholar
Turner, S. W., Toone, B. K. & Brett-Jones, J. R. (1986) Computed tomographic scan changes in early schizophrenia - preliminary findings. Psychological Medicine, 16, 219–226.10.1017/S003329170000266XCrossRefGoogle ScholarPubMed
Weinberger, D. R. (1986) The pathogenesis of schizophrenia: a neurodevelopmental theory. In Handbook of Schizophrenia: the Neurology of Schizophrenia (eds E. A. Nasrallah & D. R. Weinberger), pp. 397–406. Amsterdam: Elsevier.Google Scholar
Weinberger, D. R. Berman, K. F., Iadarola, M., et al (1987) Hat size in schizophrenia. Archives of General Psychiatry, 44, 672.10.1001/archpsyc.1987.01800190092014Google Scholar
Wilcox, J. A. & Nasrallah, H. A. (1987a) Perinatal distress and prognosis of psychotic illness. Neuropsychobiology, 17, 173–175.10.1159/000118359Google Scholar
Wilcox, J. A. & Nasrallah, H. A. (1987b) Perinatal insult as a risk factor in paranoid and nonparanoid schizophrenia. Psychopathology, 20, 285–287.10.1159/000284512Google Scholar
Zubin, J. (1986) Models for the aetiology of schizophrenia. In Handbook of Studies on Schizophrenia. Part 1: Epidemiology, Aetiology and Clinical Features (eds G. D. Burrows, T. R. Norman & G. Rubinstein), pp. 97–104. Amsterdam: Elsevier.Google Scholar
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