Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-20T02:38:49.828Z Has data issue: false hasContentIssue false
  • English
  • Français

No Genetic Linkage Detected for Schizophrenia to Xq27–q28

Published online by Cambridge University Press:  02 January 2018

Lynn E. Delisi ,
Timothy J. Crow ,
Kay E. Davies ,
Joseph D. Terwilliger ,
Jurg Ott ,
Ragnatham Ram ,
Tracey Flint  and
Angela Boccio
Lynn E. Delisi
Affiliation:
Department of Psychiatry, Health Sciences Center, SUNY Stony Brook, Stony Brook, New York 11794, USA
Timothy J. Crow
Affiliation:
Division of Psychiatry, Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex HA1 3UJ
Kay E. Davies
Affiliation:
Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU
Joseph D. Terwilliger
Affiliation:
Department of Psychiatry and Department of Genetics and Development, Columbia University, New York, USA
Jurg Ott
Affiliation:
Department of Psychiatry and Department of Genetics and Development, Columbia University, New York, USA
Ragnatham Ram
Affiliation:
Department of Psychiatry, SUNY Stony Brook, New York
Tracey Flint
Affiliation:
Institute of Molecular Medicine, University of Oxford
Angela Boccio
Affiliation:
Department of Psychiatry, SUNY Stony Brook, New York
Get access Rights & Permissions [Opens in a new window]

Abstract

The hypothesis that at least a subgroup of familial cases of schizophrenia could be due to a genetic defect on the X chromosome is supported by the observation of an excess of X-chromosome aneuploidies (XXX and XXY) among populations of patients with psychosis. The distal long arm, Xq27–q28, is a candidate region where linkage has been claimed to manic-depressive disorder and a fragile site has been associated with schizophrenia spectrum disorders. The present study excluded linkage to a large part of this region using four polymorphic probes and multipoint lod-score analysis in 10 families with multiple members with schizophrenia.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 158 , Issue 5 , May 1991 , pp. 630 - 634
Copyright
Copyright © Royal College of Psychiatrists, 1991 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
Baron, M., Risch, N., Hamberger, R., et al (1987) Genetic linkage between X chromosome markers and bipolar affective illness. Nature, 326, 289–292.CrossRefGoogle ScholarPubMed
Brown, W. T., Jenkins, E. C., Cohen, I. L., et al (1986) Fragile X and autism: a multi–center survey. American Journal of Medical Genetics, 23, 341–352.CrossRefGoogle Scholar
Collinge, J., Boccio, A. M., DeLisi, L. E., et al (1989) Evidence for a pseudoautosomal locus for schizophrenia. Cytogenetics Cell Genetics (Human Gene Mapping 10), 51, 978.Google Scholar
Collinge, J., DeLisi, L. E., Boccio, A., et al (1991) Evidence for a pseudo–autosomal locus for schizophrenia using the method of affected sibling pairs. British Journal of Psychiatry, 158, 624–629.CrossRefGoogle ScholarPubMed
Crow, T. J. (1986) The continuum of psychosis and its implication for the structure of the gene. British Journal of Psychiatry, 149, 419–429.Google Scholar
Crow, T. J. (1988) Sex chromosomes and psychosis: the case for a pseudoautosomal locus. British Journal of Psychiatry, 153, 675–683.Google Scholar
Crow, T. J., DeLisi, L. E. & Johnstone, E. C. (1989) Concordance by sex in sibling pairs with schizophrenia is paternally inherited: evidence for a pseudoautosomal locus. British Journal of Psychiatry, 155, 92–97.CrossRefGoogle ScholarPubMed
Davies, K. E., Mandel, L.–L., Weisseneach, J., et al (1987) Report of the committee on the genetic constitution of the X and Y chromosomes. Cytogenetics and Cell Genetics, 46, 277–315.Google Scholar
DeLisi, L. E., Goldin, L. E., Maxwell, M. E., et al (1987) A clinical study of siblings with schizophrenia. Archives of General Psychiatry, 44, 891–896.Google Scholar
DeLisi, L. E., Reiss, A. L., White, B. J., et al (1988) Cytogenetic studies of males with schizophrenia: screening for the fragile X chromosome and other chromosomal abnormalities. Schizophrenia Research, 1, 277–281.Google Scholar
DeLisi, L. E., & Crow, T. J. (1989) Evidence for an X chromosome locus for schizophrenia. Schizophrenia Bulletin, 15, 431–440.Google Scholar
Del Zompo, M., Bochetta, A., Goldin, L. R., et al (1984) Linkage between X chromosome markers and manic–depressive illness. Acta Psychiatrica Scandinavica, 70, 282–287.CrossRefGoogle ScholarPubMed
Fryns, J. P. (1984) The fragile X syndrome: a study of 83 families. Clinical Genetics, 26, 497–528.Google Scholar
Lathrop, G. M., Lalouel, J. M., Julier, C., et al (1984) Strategies for multilocus linkage analysis in humans. Proceedings of the National Academy of Sciences, USA, 81, 3443–3446.Google Scholar
Mandel, J.–L., Hillard, H. F., Nussbaum, R. L., et al (1989) Report of the committee on the genetic constitution of the X chromosome. Cytogenetics and Cell Genetics, 51, 384–437.Google Scholar
Maniatis, T., Fritsch, E. F. & Sambrook, J. (1982) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, New York.Google Scholar
Martin, J. B. & Bell, J. (1943) A pedigree of mental defect showing sex linkage. Journal of Neurology and Psychiatry, 6, 154–157.CrossRefGoogle ScholarPubMed
Mendlewicz, J., Linkowski, P. & Wilmotte, J. (1980) Linkage between glucose–6-phosphate dehydrogenase deficiency and manic-depressive psychosis. British Journal of Psychiatry, 137, 337–342.CrossRefGoogle ScholarPubMed
Mendlewicz, J., Sevy, S., Brocas, H., et al (1987) Polymorphic DNA marker on X chromosome and manic depression. Lancet, i, 1230–1232.CrossRefGoogle Scholar
Ott, J. (1985) Analysis of Human Genetic Linkage. Baltimore: Johns Hopkins University Press.Google Scholar
Reiss, A. L., Feinstein, C., Toomey, K. E., et al (1986) Psychiatric disability associated with the fragile X chromosome. American Journal of Medical Genetics, 23, 393–402.Google Scholar
Reiss, A. L., Hagerman, R. J., Vinogradov, S., et al (1988) Psychiatric disability in female carriers of the fragile X chromosome. Archives of General Psychiatry, 45, 25–30.CrossRefGoogle ScholarPubMed
Rogers, R. C. & Simensen, R. J. (1987) Fragile X syndrome: a common etiology of mental retardation. American Journal of Mental Deficiency, 91, 445–449.Google ScholarPubMed
Spitzer, R. L., Endicott, J. & Robins, E. (1977) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders (3rd edn). New York: Biometrics Research Division, New York State Psychiatric Institute.Google Scholar
Spitzer, R. L., Endicott, J. (1978) Schedule for Affective Disorders and Schizophrenia (SADS). New York: Biometrics Research Division, New York State Psychiatric Institute.Google Scholar
Webb, T. P., Thake, A. I., Bundey, S. E., et al (1987) A cytogenetic survey of a mentally retarded school age population with special reference to fragile sites. Journal of Mental Deficiency Research, 31, 61–71.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) Description and Classification of Psychiatric Symptoms. London: Cambridge University Press.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.