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No Evidence for a Susceptibility Locus Predisposing to Manic Depression in the Region of the Dopamine (D2) Receptor Gene

Published online by Cambridge University Press:  02 January 2018

Deborah Holmes ,
Jon Brynjolfsson ,
Peter Brett ,
David Curtis ,
Hannes Petursson ,
Robin Sherrington  and
Hugh Gurling
Deborah Holmes
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine, London
Jon Brynjolfsson
Affiliation:
Department of Psychiatry, Borgaspitalinn, Reykjavik
Peter Brett
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine, London
David Curtis
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine, London
Hannes Petursson
Affiliation:
Department of Psychiatry, Borgaspitalinn, Reykjavik, Iceland
Robin Sherrington
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine, London
Hugh Gurling*
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine, London, Riding House Street, London W1P 7PN
*
∗Correspondence
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Abstract

Recent reports of cytogenetic abnormalities linked to psychiatric illness and the localisations of the genes for the dopamine (D2) receptor and tyrosinase on the long arm of chromosome 11 have suggested that susceptibility loci for schizophrenia and manic depression might be situated in this region. We could find no evidence for linkage in five Icelandic pedigrees between manic depression and markers in this region, and we have excluded candidate genes coding for the D2 receptor and tyrosinase. We conclude that mutations at loci in this region are not a common cause of manic depression in the population studied.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 158 , Issue 5 , May 1991 , pp. 635 - 641
Copyright
Copyright © Royal College of Psychiatrists, 1991 

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