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No Evidence for a Pseudoautosomal Locus for Schizophrenia

Linkage Analysis of Multiply Affected Families

Published online by Cambridge University Press:  02 January 2018

P. Asherson ,
E. Parfitt ,
M. Sargeant ,
S. Tidmarsh ,
P. Buckland ,
C. Taylor ,
A. Clements ,
M. Gill ,
P. Mcguffin  and
M. Owen
P. Asherson*
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF4 4XN
E. Parfitt
Affiliation:
Department of Medical Genetics, University of Wales College of Medicine, Cardiff
M. Sargeant
Affiliation:
St Tydfil's Hospital, Merthyr Tyafil
S. Tidmarsh
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff
P. Buckland
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff
C. Taylor
Affiliation:
Institute of Psychiatry, London
A. Clements
Affiliation:
Genetics Section, Institute of Psychiatry, London
M. Gill
Affiliation:
Genetics Section, Institute of Psychiatry, London
P. Mcguffin
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff
M. Owen
Affiliation:
Departments of Medical Genetics and Psychological Medicine, University of Wales College of Medicine, Cardiff
*
∗Correspondence
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Abstract

Evidence for a pseudoautosomal locus for a schizophrenia susceptibility gene was sought by two forms of analysis of 25 multiply affected families. Firstly, in the sample as a whole there was an excess of same-sex over mixed-sex siblings compared with that expected. Secondly, linkage analysis was performed in six of the families. The genotypes were studied for DXYS14, a highly polymorphic marker in the telomeric pseudoautosomal region. No evidence for positive linkage was found with two-point analysis under eight different genetic models for the mode of transmission. A non-parametric, sibling-pair analysis also failed to detect linkage. Our findings provide no evidence for linkage within the pseudoautosomal region; same-sex concordance must arise from some other mechanism.

Type
Papers
Information
The British Journal of Psychiatry , Volume 161 , Issue 1 , July 1992 , pp. 63 - 68
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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