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The Nithsdale Schizophrenia Surveys. XIV: Plasma Lipid Peroxide and Serum Vitamin E Levels in Patients with and Without Tardive Dyskinesia, and in Normal Subjects

Published online by Cambridge University Press:  02 January 2018

Robin G. McCreadie ,
Elizabeth MacDonald ,
David Wiles ,
Graham Campbell  and
John R. Paterson
Robin G. McCreadie*
Affiliation:
Crichton Royal Hospital, Dumfries
Elizabeth MacDonald
Affiliation:
Crichton Royal Hospital, Dumfries
David Wiles
Affiliation:
Department of Biochemistry, Dumfries and Galloway Royal Infirmary, Dumfries
Graham Campbell
Affiliation:
Department of Biochemistry, Dumfries and Galloway Royal Infirmary, Dumfries
John R. Paterson
Affiliation:
Department of Biochemistry, Dumfries and Galloway Royal Infirmary, Dumfries
*
Dr R. G. McCreadie, Director of Clinical Research, Crichton Royal Hospital, Dumfries DG1 4TG
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Abstract

Background

Tardive dyskinesia (TD) may be mediated through free radical damage to neurons. Plasma lipid peroxide levels are a measure of radical damage to fats. Vitamin E is a free radical scavenger.

Method

One hundred and twenty-eight schizophrenic patients were examined for TD using the Abnormal Involuntary Movements Scale. Blood samples were taken to measure plasma lipid peroxide, serum vitamin E and cholesterol, and vitamin Exholesterol ratios. Twenty-four patients were also examined in October 1993, January 1994, and April 1994. Biochemical results were compared in 81 patients and 79 normal subjects.

Results

Patients with and without TD did not differ in median plasma lipid peroxide and serum vitamin E levels, or vitamin Exholesterol ratios. Correlations between seasonal change scores in TD and biochemical measurements were low. Lipid peroxide levels were higher and vitamin Exholesterol ratios lower in patients than in normal subjects. Vitamin E levels were lowest in in-patients and in those living in supported accommodation.

Conclusions

The results do not support the hypothesis that TD is mediated through free radical damage to neurons, but suggest increased free radical activity in schizophrenia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 167 , Issue 5 , November 1995 , pp. 610 - 617
Copyright
Copyright © 1995 The Royal College of Psychiatrists 

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