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The Nithsdale Schizophrenia Surveys X: Obstetric Complications, Family History and Abnormal Movements

Published online by Cambridge University Press:  02 January 2018

Robin G. McCreadie*
Affiliation:
Dykebar Hospital, Paisley
David J. Hall
Affiliation:
Dykebar Hospital, Paisley
Ian J. Berry
Affiliation:
Newcastle Regional Health Authority
Lesley J. Robertson
Affiliation:
Southern General Hospital, Glasgow
James I. Ewing
Affiliation:
Department of Clinical Research, Crichton Royal Hospital, Dumfries DG1 4TG, Scotland
Michael F. Geals
Affiliation:
Cresswell Hospital, Dumfries DG1 4AP
*
Correspondence

Abstract

Obstetric histories of 54 schizophrenic patients and 114 siblings were obtained from their mothers and scored using the Obstetric Complications Scale. There was no statistically significant difference in the proportion of schizophrenic patients (35%) and siblings (29%) who had at least one definite obstetric complication. There was no evidence that schizophrenic patients with a history of obstetric complications were less likely to have a first-degree relative with a history of psychiatric illness leading to in-patient care. Schizophrenic patients with a history of obstetric complications were more likely to have drug-induced Parkinsonism. There was a trend for tardive dyskinesia to be more common in those schizophrenic patients with no obstetric complications but a family history of schizophrenia.

Type
Papers
Copyright
Copyright © The Royal College of Psychiatrists 

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References

American Psychiatric Association (1967) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.Google Scholar
Barnes, T. R. E. (1989) A rating scale for drug-induced akathisia. British Journal of Psychiatry, 154, 672676.Google Scholar
DeLisi, L. E., Goldin, L. R., Maxwell, E., et al (1987) Clinical features of illness in siblings with schizophrenic or schizoaffective disorder. Archives of General Psychiatry, 44, 891896.Google Scholar
Done, J., Crow, T. J., Frith, C. D., et al (1990) Pregnancy and birth complications as causes of psychiatric illness in adult life: a study utilising the perinatal morbidity study (1958). Schizophrenia Research, 3, 91.Google Scholar
Eagles, J. M., Gibson, I., Bremner, M. H., et al (1990) Obstetric complications in DSM–III schizophrenics and their siblings. Lancet, 335, 11391141.Google Scholar
Gillberg, C., Waalstrom, J., Forsman, A., et al (1986) Teenage psychoses – epidemiology, classification and reduced optimality in the pre-, peri- and neonatal periods. Journal of Child Psychology and Psychiatry, 27, 8798.CrossRefGoogle ScholarPubMed
Jacobsen, B. & Kinney, D. K. (1980) Perinatal complications in adopted and non-adopted schizophrenics and their controls. Acta Psychiatrica Scandinavica, 62 (suppl. 285), 337346.Google Scholar
Lane, E. A. & Albee, G. W. (1966) Comparative birth weights of schizophrenics and their siblings. Journal of Psychology, 64, 227231.Google Scholar
Lewis, S. W. (1989) Congenital risk factors for schizophrenia. Psychological Medicine, 19, 513.Google Scholar
Lewis, S. W. & Murray, R. M. (1987) Obstetric complications, neurodevelopmental deviance and schizophrenia. Journal of Psychiatric Research, 21, 413421.Google Scholar
Lewis, S. W., Owen, M. J. & Murray, R. M. (1989) Obstetric complications and schizophrenia: methodology and mechanisms. In Schizophrenia: Scientific Progress (eds Schulz, S. C. & Tamminga, C. A.). New York: Oxford University Press.Google Scholar
McCreadie, R. G. (1982) The Nithsdale schizophrenia survey. I. Psychiatric and social handicaps. British Journal of Psychiatry, 140, 582586.Google Scholar
McCreadie, R. G., Robertson, L. J. & Wiles, D. H. (1992) The Nithsdale schizophrenia surveys. IX. Akathisia, parkinsonism, tardive dyskinesia and plasma neuroleptic levels. British Journal of Psychiatry, 161, 793799.Google Scholar
McGuffin, P., Farmer, A. & Gottesman, I. (1987) Is there really a split in schizophrenia: the genetic evidence. British Journal of Psychiatry, 150, 581592.CrossRefGoogle ScholarPubMed
McNeil, T. F. & Kaij, L. (1978) Obstetric factors in the development of schizophrenia. In The Nature of Schizophrenia (eds Wynne, L. C., Cromwell, R. L. & Matthysee, S.). New York: John Wiley.Google Scholar
Murray, R. M., Lewis, S. W. & Reveley, A. M. (1985) Towards an aetiological classification of schizophrenia. Lancet, i, 10231026.Google Scholar
Nimgaonkar, V. L., Wessely, S. & Murray, R. M. (1988) Prevalence of familiality, obstetric complications and structural brain damage in schizophrenic patients. British Journal of Psychiatry, 153, 191197.CrossRefGoogle ScholarPubMed
O'Callaghan, E. O., Larkin, C., Kinsella, A., et al (1990a) Obstetric complications, the putative familial-sporadic distinction, and tardive dyskinesia in schizophrenia. British Journal of Psychiatry, 157, 578584.Google Scholar
O'Callaghan, E. O., Larkin, C., & Waddington, J. L. (1990b) Obstetric complications in schizophrenia and the validity of maternal recall. Psychological Medicine, 20, 8994.Google Scholar
Owen, M. & McGuffin, P. (1990) Obstetric complications and schizophrenia. Lancet, 336, 122.Google Scholar
Parnas, J., Schulsinger, F., Teasdale, T. W., et al (1982) Perinatal complications and clinical outcome within the schizophrenia spectrum. British Journal of Psychiatry, 140, 416420.Google Scholar
Pollack, M. & Greenberg, I. M. (1966) Paranatal complications in hospitalized schizophrenics and non-schizophrenic patients. Journal of the Hillside Hospital, 15, 191204.Google Scholar
Schooler, N. R. & Kane, J. M. (1982) Research diagnoses for tardive dyskinesia. Archives of General Psychiatry, 39, 486487.Google Scholar
Simpson, G. M. & Angus, J. W. S. (1970) A rating scale for extrapyramidal side effects. Acta Psychiatrica Scandinavica (suppl. 212), 1119.Google Scholar
Turner, S. W., Toone, B. K. & Brett-Jones, J. R. (1986) Computerised tomographic scan changes in early schizophrenia – preliminary findings. Psychological Medicine, 16, 219225.CrossRefGoogle ScholarPubMed
US Department of Health, Welfare and Education (1976) Abnormal involuntary movements scale. In ECDEU Assessment Manual (ed. Guy, W.). Rockville, Maryland: US Department of Health, Education and Welfare.Google Scholar
Waddington, J. L., Youssef, H. A. & Kinsella, A. (1990) Cognitive dysfunction in schizophrenia followed up over 5 years and its longitudinal relationship to the emergence of tardive dyskinesia. Psychological Medicine, 20, 835842.CrossRefGoogle Scholar
Woerner, M. G., Pollack, M. & Klein, D. F. (1973) Pregnancy and birth complications in psychiatric patients: a comparison of schizophrenia and personality disorder patients with their siblings. Acta Psychiatrica Scandinavica, 49, 712721.Google Scholar
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