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A neuropsychological perspective on three schizophrenic patients with midline structural defects

Published online by Cambridge University Press:  03 January 2018

N. M. J. Edelstyn ,
F. Oyebode ,
M. J. Riddoch ,
R. Soppitt ,
H. Moselhy  and
M. George
N. M. J. Edelstyn*
Affiliation:
University Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, Birmingham
F. Oyebode
Affiliation:
University Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, Birmingham
M. J. Riddoch
Affiliation:
School of Psychology, University of Birmingham
R. Soppitt
Affiliation:
University Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, Birmingham
H. Moselhy
Affiliation:
University Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, Birmingham
M. George
Affiliation:
University Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, Birmingham
*
Dr N. M. J. Edelstyn, University Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, Mindelsohn Way, Birmingham BI52QZ
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Abstract

Background

The relationship between midline structural defects and schizophrenia remains unclear, although a number of neuroradiological studies have reported an association between schizophrenia and a range of anomalies.

Method

Three patients are reported, each diagnosed with schizophrenia and neuroradiological evidence of midline structural anomalies. MRI scans are reported in conjunction with performance over a range of neuropsychological tests designed to assess frontal and lateralised cognitive functions.

Results

Evidence of anterior dysfunction was present in all three cases, while on an individual basis patients displayed varying patterns of preserved and dysfunctional cognitive processing.

Conclusion

The reported findings raise a number of interesting issues regarding the nature of hemispheric involvement in schizophrenia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 170 , Issue 5 , May 1997 , pp. 416 - 421
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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References

Bantall, R. P. (1994) Cognitive biases and abnormal beliefs: Towards a model of persecutory delusions. In The Neuropsychology of Schizophrenia (eds A. S. David & J. C. Cutting), pp. 337–360. Oxford: Oxford University Press.Google Scholar
Cutting, J. (1994) Evidence for right hemisphere dysfunction in schizophrenia. In The Neuropsychology of Schizophrenia (eds A. S. David & J. C. Cutting), pp. 231–241. Oxford: Oxford University Press.Google Scholar
Cutting, J. & Murphy, D. (1988) Schizophrenic thought disorder: A psychological and organic interpretation. British journal of Psychiatry, 152, 310–319.Google Scholar
David, A. S. (1987) Tachistoscopic tests of colour naming and matching in schizophrenia: evidence for posterior callosum dysfunction. Psychological Medicine, 17, 621–630.CrossRefGoogle ScholarPubMed
David, A. S. (1989) Perceptual asymmetry for happy-sad chimeric faces: effects of mood. Neuropsychologia. 27, 1289–1300.Google Scholar
David, A. S. (1993a) Spatial and selective attention in the cerebral hemispheres in depression, mania and schizophrenia. Brain and Cognition. 23, 166–180.CrossRefGoogle ScholarPubMed
David, A. S. (1993b) Callosal transfer in schizophrenia: too much or too little, journal of Abnormal Psychology, 102, 573–579.Google Scholar
David, A. S. (1994) Schizophrenia and the corpus callosum: developmental. structural and functional relationships. Behavioural Brain Reseoizh, 64, 203–211.CrossRefGoogle ScholarPubMed
Edaletyn, N. M. J. Riddoch, M. J., Oyebode, F., et al (1996) Visual processing in patients with Fregoli syndrome, journal of Neuropsychiatry, 1, 103–124.Google Scholar
Eilis, A. W. & Young, A. W. (1988) Human Cognitive Neuropsychology. London: LEA.Google Scholar
Heaton, R. K., Cheiune, G. J., Talley, J.L., et al (1989) Wisconsin Card Sorting Test. Odessa, FL: Psychological Assessment Resources, Inc. Google Scholar
Hellewell, J. S. E., Connell, J. & Dealdn, J. F. W. (1994) Affect judgement and facial recognition memory in schizophrenia. Psychopathology 27, 255–261.Google Scholar
Huq, S. F., Garety, P. A. & Heimsley, D. R. (1988) Probabilistic judgements of deluded and nondeluded subjects. Quarterly journal of Experimental Psychology: Human Learning and Memory, 40A, 801–812.Google Scholar
Kay, J., Lesser, R. & Coitheart, M. (1992) Psycholinguistic Assessments of Language Processing in Aphasia. Hove: LEA.Google Scholar
Kertesz, A. (1987) The clinical spectrum and localisation of visual agnosia. In Visual Object Processing: A Cognitive Neuropsychological Approach (eds G. W. Humphreys & M. J. Riddoch), pp. 175–196. Hove: LEA.Google Scholar
Uddle, P. F. (1987) Schizophrenic syndromes, cognitive performance and neurological function. Psychological Medicine. 17, 49–57.Google Scholar
Uddle, P. F. & Morris, D. L. (1991) Schizophrenic syndromes and frontal lobe performance. British journal of Psychiatry 158, 340–345.Google Scholar
Nelson, H. E. (1982) National Adult Reading Test. Windsor: NFER-Nelson.Google Scholar
Newcombe, F. A. Marshall, J. C. (1984) Varieties of acquired dyslexia: a linguistic approach. Seminars in Neurology 4, 181–195.Google Scholar
Randam, P. L. (1983) Schizophrenia, abnormal connections and brain evolution. Medical Hypotheses. 10, 247–280.Google Scholar
Riddoch, M. J. & Humphreys, G. W. (1993) Birmingham Object Recognition Battery Hove: LEA.Google Scholar
Sartori, G., Job, R. & Colthoart, M. (1990) The neuropsychology of visual semantics. In Attention and Performance, XIV (eds D. E. Meyer & S. Kornblum). Hillsdale, NJ: LEA.Google Scholar
Stroop, J. R. (1989) Stroop Test. Odessa. FL: Psychological Assessment Resources. Inc.Google Scholar
Stuss, D.T. & Bonson, D. F. (1988) The Frontal Lobes. New York: McGraw Hill.Google Scholar
Swayza, V. W., Andresson, N. C., Ehrhardt, J. C., et al (1990) Development abnormalities of the corpus callosum in schizophrenia. Archives of Neurology 47, 805–808.CrossRefGoogle Scholar
Tassinari, G., Aglioti, S., Paltini, R., et al (1994) Interhemispheric integration of simple visuomotor responses in patients with partial callosal defects. Behavioural Brain Research. 64, 141–149.Google Scholar
Warrington, E. K. (1984) Warrington Recognition Memory Test (WRMT). Windsor: NFER-Nelson.Google Scholar
Warrington, E. K. & Jamas, M. (1988) Visual apperceptive agnosia: a clinico-anatomical study of three cases. Cortex. 24, 13–32.Google Scholar
Warrington, E. K. & Jamas, M. (1991) Visual Object and Space Perception Battery (VOSP). Fareham, Hants.: Thames Valley Test Company.Google Scholar
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