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Neuronal Misconnections and Psychiatric Disorder

Is There a Link?

Published online by Cambridge University Press:  02 January 2018

Robert Goodman
Robert Goodman*
Affiliation:
Department of Child Psychiatry, Institute of Child Health, Guilford Street, London WC1N 1EH
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Abstract

Brain damage can induce anomalous neuronal connections in experimental animals, which can sometimes result in maladaptive behaviour, particularly when damage occurs early in development. Anomalous patterns of neuronal connection can also arise from genetic disorders. In humans, neuronal misconnections could be involved in a variety of psychiatric disorders. For example, they may account for the link between hyperkinesis and childhood hemiplegia, and for the link between schizophrenia and ‘alien tissue’ lesions of the temporal lobes. Predictions from misconnection hypotheses can potentially be tested in neuropathological, neurophysiological, and clinical studies.

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Comment
Information
The British Journal of Psychiatry , Volume 154 , Issue 3 , March 1989 , pp. 292 - 299
Copyright
Copyright © Royal College of Psychiatrists, 1989 

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References

Bear, D. M. (1979) Temporal lobe epilepsy – a syndrome of sensory-limbic hyperconnection. Cortex, 15, 357–384.Google Scholar
Chan-Palay, V. (1987) Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections; coexistence with neuropeptide Y neurons, and effects in Alzheimer-type dementia. Journal of Comparative Neurology, 260, 201–223.CrossRefGoogle ScholarPubMed
Corbett, J. A. & Campbell, H. J. (1981) Causes of severe self-injurious behavior. In Frontiers of Knowledge in Mental Retardation, vol. 2 (ed. Mittler, P.). Baltimore: University Park Press.Google Scholar
Cowan, W. M., Fawcett, J. W., O'Leary, D. D. M., et al (1984) Regressive events in neurogenesis. Science, 225, 1258–1265.Google Scholar
Creel, D., O'Donnell, F. E. Jr & Witkop, C. J. Jr (1978) Visual system anomalies in human ocular albinos. Science, 201, 931–933.Google Scholar
Crow, T. J. (1980) Molecular pathology of schizophrenia: more than one disease process? British Medical Journal, i, 66–68.CrossRefGoogle Scholar
Davison, K. & Bagley, C. R. (1969) Schizophrenia-like psychoses associated with organic disorders of the central nervous system: a review of the literature. British Journal of Psychiatry, Special Publication No. 4, 113 184.Google Scholar
Dennis, M. & Whittaker, H. A. (1977) Hemispheric equipotentiality and language acquisition. In Language Development and Neurological Theory (eds Segalowitz, S. J. & Gruber, F. A.). New York: Academic Press.Google Scholar
Edelman, G. M. (1983) Cell adhesion molecules. Science, 219, 450–457.Google Scholar
Falconer, M. A., Serafetinides, E. A. & Corsellis, J. A. (1964) Etiology and pathogenesis of temporal lobe epilepsy. Archives of Neurology, 10, 233–248.Google Scholar
Finger, S. & Stein, D. G. (1982) Brain Damage and Recovery: Research and Clinical Perspectives. New York: Academic Press.Google Scholar
Flor-Henry, P. (1969) Psychosis and temporal lobe epilepsy: a controlled investigation. Epilepsia, 10, 363–395.Google Scholar
Goff, W. R., Allison, T. & Vaughan, H. G. (1978) The functional neuroanatomy of event related potentials. In Event-Related Brain Potentials in Man (eds Callaway, E., Tueting, P. & Koslow, S. H.). New York: Academic Press.Google Scholar
Goldman-Rakic, P. S., Isseroff, A., Schwartz, M. L., et al (1983) The neurobiology of cognitive development. In Mussen's Handbook of Child Psychology (4th edn), vol. II, Infancy and Developmental Psychobiology (eds Haith, M. M. & Campos, J. J.). New York: Wiley.Google Scholar
Goodman, R. (1986) Hemispherectomy and its alternatives in the treatment of intractable epilepsy in patients with infantile hemiplegia. Developmental Medicine and Child Neurology, 28, 251–258.Google Scholar
Goodman, R. (1987) The developmental neurobiology of language. In Language Development and Disorders. Clinics in Developmental Medicine Nos. 101/102 (eds Yule, W. & Rutter, M.). London: MacKeith Press/Blackwell.Google Scholar
Guillery, R. W., Okoro, A. N. & Witkop, C. J. Jr (1975) Abnormal visual pathways in the brain of a human albino. Brain Research, 96, 373–377.Google Scholar
Harden, A. (1982) Maturation of the visual evoked potentials. In Clinical Application of Cerebral Evoked Potentials in Pediatric Medicine (eds Chiarenza, G. A. & Papakostopoulos, D.). Amsterdam: Excerpta Medica.Google Scholar
Huttenlocher, P. R. (1979) Synaptic density in human frontal cortex – developmental changes and effects of aging. Brain Research, 163, 195–205.Google ScholarPubMed
Ingram, T. T. S. (1955) A study of cerebral palsy in the childhood population of Edinburgh. Archives of Disease in Childhood, 30, 85–98.Google Scholar
Ingram, T. T. S. (1956) A characteristic form of overactive behaviour in brain damaged children. Journal of Mental Science, 102, 550–558.Google Scholar
Jacobson, M. (1978) Developmental Neurobiology (2nd edn). New York: Plenum.Google Scholar
Jakob, H. & Beckmann, H. (1986) Prenatal developmental disturbances in the limbic allocortex in schizophrenics. Journal of Neural Transmission, 65, 303–326.CrossRefGoogle ScholarPubMed
Janowsky, J. S. & Finlay, B. L. (1986) The outcome of perinatal brain damage: the role of normal neuronal loss and axonal retraction. Developmental Medicine and Child Neurology, 28, 375–389.Google Scholar
Kovelman, J. A. & Scheibel, A. B. (1984) A neurohistological correlate of schizophrenia. Biological Psychiatry, 19, 1601–1621.Google ScholarPubMed
Kritzer, M. F., Innis, R. B. & Goldman-Rakic, P. S. (1987) Regional distribution of cholecystokinin receptors in primate cerebral cortex determined by in vitro receptor autoradiography. Journal of Comparative Neurology, 263, 418–435.Google Scholar
Lewis, D. A., Campbell, M. J., Foote, S. L., et al (1987) The distribution of tyrosine hydroxylase-immunoreactive fibers in primate neocortex is widespread but regionally specific. Journal of Neuroscience, 7, 279–290.Google Scholar
Lishman, W. A. (1987) Organic Psychiatry: The Psychological Consequences of Cerebral Disorder (2nd edn). Oxford: Blackwell.Google Scholar
Lockerbie, R. O. (1987) The neuronal growth cone: a review of its locomotory, navigational and target recognition capabilities. Neuroscience, 20, 719–729.Google Scholar
Lund, R. D. (1978) Development and Plasticity of the Brain. New York: Oxford University Press.Google Scholar
Nichols, P. L. & Chen, T. C. (1981) Minimal Brain Dysfunction – A Prospective Study. Hillsdale, New Jersey: Lawrence Erlbaum.Google Scholar
Nuechterlein, K. H. (1986) Childhood precursors of adult schizophrenia. Journal of Child Psychology and Psychiatry, 27, 133–144.CrossRefGoogle ScholarPubMed
Ounsted, C. (1955) The hyperkinetic syndrome in epileptic children. Lancet, ii, 303–311.CrossRefGoogle Scholar
Ounsted, C., Lindsay, J. & Norman, R. (1966) Biological Factors in Temporal Lobe Epilepsy. Clinics in Developmental Medicine No. 22. London: SIMP/Heinemann.Google Scholar
Prechtl, H. F. R. (1978) Minimal brain dysfunction syndrome and the plasticity of the nervous system. In Advances in Biological Psychiatry, vol 1. Minimal Brain Dysfunction: Fact or Fiction (eds Kalverboer, A. F., van Praag, H. M. & Mendelewicz, J.). Basel: Karger.Google Scholar
Randall, P. L. (1980) A neuroanatomical theory on the aetiology of schizophrenia. Medical Hypotheses, 6, 645–658.CrossRefGoogle ScholarPubMed
Randall, P. L. (1981) An alternative mechanism of action for neuroleptic and antidepressant drugs. Medical Hypotheses, 7, 251–260.Google Scholar
Randall, P. L. (1983) Schizophrenia, abnormal connection, and brain evolution. Medical Hypotheses, 10, 247–280.Google Scholar
Rossor, M. N. (1981) Parkinson's disease and Alzheimer's disease as disorders of the isodendritic core. British Medical Journal, ii, 1588–1590.Google Scholar
Rutter, M., Graham, P. & Yule, W. (1970) A Neuropsychiatry Study in Childhood. Clinics in Developmental Medicine Nos. 35/36. London: SIMP/Heinemann.Google Scholar
Schneider, G. E. (1979) Is it really better to have your brain lesion early? A revision of the “Kennard principle”. Neuropsychologia, 17, 557–583.CrossRefGoogle Scholar
Smith, A. & Sugar, O. (1975) Development of above normal language and intelligence 21 years after left hemispherectomy. Neurology, 25, 813–818.Google Scholar
Spiers, P. A., Schomer, D. L., Blume, H. W., et al (1985) Temporolimbic epilepsy and behavior. In Principles of Behavioral Neurology (ed. Mesulam, M-M.). Philadelphia: Davis.Google Scholar
Taylor, D. C. (1972) Mental state and temporal lobe epilepsy: a correlative account of 100 patients treated surgically. Epilepsia, 13, 727–765.Google Scholar
Taylor, D. C. (1975) Factors influencing the occurrence of schizophrenialike psychosis in patients with temporal lobe epilepsy. Psychological Medicine, 5, 249–254.Google Scholar
Taylor, D. C. (1977) Epileptic experience, schizophrenia and the temporal lobe. McLean Hospital Journal, June, 22 39.Google Scholar
Taylor, E. (1986) Overactivity, hyperactivity and hyperkinesis: problems and prevalence. In The Overactive Child. Clinics in Developmental Medicine No. 97 (ed. Taylor, E.). London: MacKeith Press/Blackwell.Google Scholar
Trimble, M. R. (1983) Interictal behaviour and temporal lobe epilepsy. In Recent Advances in Epilepsy (eds Pedley, T. A. & Meldrum, B. S.). Edinburgh: Churchill Livingstone.Google Scholar
van Praag, H. M. (1978) Amine hypothesis of affective disorders. In Biology of Mood and Antianxiety Drugs. Handbook of Psychopharmacology, vol. 13 (eds Iversen, L. L., Iversen, S. D. & Snyder, S. H.). New York: Plenum.Google Scholar
Varoha-Khadem, F., O'Gorman, A. M., & Watters, G. V. (1985) Asphasia and handedness in relation to hemispheric side, age at injury and severity of cerebral lesion during childhood. Brain, 108, 677–696.Google Scholar
Weintraub, S. & Mesulam, M-M. (1983) Developmental learning disabilities of the right hemisphere: emotional, interpersonal and cognitive components. Archives of Neurology, 40, 463–468.Google Scholar
Woods, B. T. & Carey, S. (1979) Language deficits after apparent clinical recovery from childhood aphasia. Annals of Neurology, 6, 405–409.Google Scholar
Zeitlin, H. (1986) The Natural History of Psychiatric Disorder in Children. Maudsley Monographs No. 29. Oxford: Oxford University Press.Google Scholar
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