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The Neuroleptic Hypothesis: Study of the Covariation of Extrapyramidal and Therapeutic Drug Effects

Published online by Cambridge University Press:  29 January 2018

M. Alpert ,
F. Diamond ,
J. Weisenfreund ,
E. Taleporos  and
A. J. Friedhoff
M. Alpert
Affiliation:
Department of Psychiatry
F. Diamond
Affiliation:
Department of Psychiatry
J. Weisenfreund
Affiliation:
Department of Psychiatry
E. Taleporos
Affiliation:
Millhauser Laboratories of the Department of Psychiatry, New York University, School of Medicine, 550 First Avenue, New York, NY. 10016, U.S.A.
A. J. Friedhoff
Affiliation:
Albert Einstein Medical College
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Summary

A therapeutic trial with chlorpromazine was conducted with a homogeneous (for age and sex) group of recently admitted schizophrenic patients. Extrapyramidal effects were measured through quantitative analysis of digital tremor, after four days of fixed-dose treatment. Assessment of treatment efficacy was based on Brief Psychiatric Rating Scale ratings, done at the end of four weeks' treatment. Those patients whose tremor was least affected by drug were most likely to benefit from the treatment. Implications of this negative correlation for our understanding of the neuroleptic hypothesis and the closely associated dopamine hypothesis of schizophrenia are discussed.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 133 , Issue 2 , August 1978 , pp. 169 - 175
Copyright
Copyright © Royal College of Psychiatrists, 1978 

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