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Neuroanatomical Studies of Major Affective Disorders

A Review and Suggestions for Further Research

Published online by Cambridge University Press:  02 January 2018

Dilip V. Jeste ,
James B. Lohr  and
Frederick K. Goodwin
Dilip V. Jeste*
Affiliation:
University of California
James B. Lohr
Affiliation:
San Diego Veterans Administration Hospital (V-116A)
Frederick K. Goodwin
Affiliation:
Intramural Program, NIMH, Clinical Center, Bethesda
*
∗San Diego Veteran's Administration Hospital, Psychiatric Services (V-116A), 3350 La Jolla Village Drive, San Diego, California 92161, USA
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Abstract

Interest in the long-neglected neuropathology of major affective disorders has recently been rekindled, partly because of the emergence of brain-imaging techniques. We review the literature suggesting that attention be given to the neuroanatomy and neuropathology of primary and secondary affective disorders. Computerised tomography studies show that patients with affective disorders tend to be similar to schizophrenic patients and significantly different from normal control subjects in ventricle:brain ratio, sulcal widening, and cerebellar vermian atrophy. As yet, there are few neuropathological investigations of the brains of patients with primary affective disorders. Suggestions for further research in the neuropathology of affective disorders are offered.

Type
Review Article
Information
The British Journal of Psychiatry , Volume 153 , Issue 4 , October 1988 , pp. 444 - 459
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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