Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-22T08:02:14.240Z Has data issue: false hasContentIssue false
  • English
  • Français

Neoplastic Liability in Klinefelter's Syndrome

Published online by Cambridge University Press:  29 January 2018

L. R. Robinson
L. R. Robinson*
Affiliation:
Purdysburn Hospital, Belfast 8
Get access Rights & Permissions [Opens in a new window]

Extract

One of the common clinical interests shared by physicians and psychiatrists is the genetically determined syndrome to which Klinefelter has given his name. Over the past few years positive identification has become possible through advances in cytogenetics, and more recently evidence has been accumulating which seems to indicate that a significant correlation may exist between Klinefelter's Syndrome and the development of other diseases, malignant disease in particular. Mental retardation is one of the most common symptoms found in the syndrome, so the psychiatrist is often in the best position to detect it. The case to be described here as well as having a few interesting facets of psychopathology may also provide more evidence of the pathological loading which the basic genetic abnormality seems to carry.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 112 , Issue 488 , July 1966 , pp. 713 - 715
Copyright
Copyright © Royal College of Psychiatrists, 1966 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bradbury, J. T. Bunge, R. G. and Boccabella, R. A. (1956). “Chromatin test in Klinefelter's syndrome”. J. clin. Endocrin., 16, 689.CrossRefGoogle Scholar
Burt, A. S. Reiner, L. Cohen, R. B. and Sniffen, R. C. (1954). “Klinefelter's syndrome: report of an autopsy with particular reference to the histology and histochemistry of the endocrine glands”. Ibid., 14, 719–727.Google Scholar
Daly, J. J. and Rickards, D. F. (1964). “Klinefelter's syndrome with asthma”. Lancet, i, 1451–1452.Google Scholar
Ferguson-Smith, M. A. Lennox, B. Mack, W. S. and Stewart, J. S. S. (1957). “Klinefelter's syndrome: frequency and testicular morphology in relation to nuclear sex.” Ibid., ii, 167–169.Google Scholar
Jackson, A. W. Muldal, S. Ockey, C. H. and O'Connor, P. J. (1965). “Carcinoma of male breast in association with the Klinefelter syndrome”. Brit. med. J., i, 223–225.Google Scholar
Klinefelter, H. F. Reifenstein, E. C. and Albright, F. (1942). “Syndrome characterized by gynecomastia, aspermatogenesis without A-leydigism, and increased excretion of follicle-stimulating hormone”. J. clin. Endocrin., 2, 615–627.CrossRefGoogle Scholar
Lubs, H. A. (1962). “Testicular size in Klinefelter's syndrome in men over 50”. New Engl. J. Med., 267, 326–331.Google Scholar
McClean, N. Harnden, D. G. Court Brown, W. M. Bond, J. and Mantle, D. J. (1964). “Sex chromosome abnormalities in new born babies”. Lancet, i, 286–290.Google Scholar
McSween, R. N. M. (1965). “Reticulum-cell sarcoma and rheumatoid arthritis in a patient with XY/XXY/XXXY Klinefelter's syndrome and normal intelligence.” Ibid., i, 460–461.Google Scholar
Mamunes, P. Lapidus, P. H. Abbott, J. A. and Roath, S. (1961). “Acute leukaemia and Klinefelter's syndrome.” Ibid., ii, 26–27.Google Scholar
Nielsen, J. and Fischer, M. (1965). “Sex-chromatin and sex-chromosome abnormalities in male hypogonadal mental patients”. Brit. J. Psychiat., 111, 641–647.Google Scholar
Stewart, J. S. S. Mack, W. S. Govan, A. D. T. Ferguson-Smith, M. A. and Lennox, B. (1959). “Klinefelter's syndrome: clinical and hormonal aspects”. Quart. J. Med., 28, 561–571.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.