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Negative Symptoms at Discharge and Outcome in Schizophrenia

Published online by Cambridge University Press:  02 January 2018

Hai-Gwo Hwu ,
Happy Tan ,
Chu-Chang Chen  and
Ling-Ling Yeh
Hai-Gwo Hwu*
Affiliation:
Department of Psychiatry, College of Medicine, National Taiwan University
Happy Tan
Affiliation:
Department of Psychiatry, College of Medicine, National Taiwan University
Chu-Chang Chen
Affiliation:
Department of Psychiatry, College of Medicine, National Taiwan University
Ling-Ling Yeh
Affiliation:
Department of Psychiatry, College of Medicine, National Taiwan University
*
Professor Hai-Gwo Hwu, Department of Psychiatry, National Taiwan University Hospital, No. 7 Chung-Shan S. RD, Taipei, Taiwan 100, Republic of China
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Abstract

Background

The clinical significance in schizophrenia of positive and negative symptoms at discharge was assessed.

Method

Of schizophrenic patients fulfilling DSM–III criteria, 113 were recruited for this study. Personal, social and psychopathological data were collected and all cases were followed up at one and two years after discharge.

Results

The presence of positive symptoms (64 cases), without concomitant negative symptoms, did not predict the follow-up social function and positive symptom score. Conversely, the presence of negative symptoms (31 cases) predicted worse social functioning (P < 0.05 to P < 0.005) and higher positive symptom scores (P < 0.01) at follow-up using MANOVA. Eighteen cases (15.9%) had neither positive nor negative symptoms and had the best clinical outcome.

Conclusions

Negative, but not positive, symptoms assessed at discharge are an important predictor of poor outcome. In addition, negative symptoms may themselves expose a biological vulnerability to the presence of positive symptoms.

Type
Papers
Information
The British Journal of Psychiatry , Volume 166 , Issue 1 , January 1995 , pp. 61 - 67
Copyright
Copyright © 1995 The Royal College of Psychiatrists 

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