Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-22T16:27:40.306Z Has data issue: false hasContentIssue false
  • English
  • Français

Morbidity Risks of Schizophrenia and Affective Disorders among First-Degree Relatives of Patients with Schizoaffective Disorders

Published online by Cambridge University Press:  02 January 2018

Ming T. Tsuang
Ming T. Tsuang*
Affiliation:
Departments of Psychiatry and Epidemiology, Harvard University; Harvard Schools of Medicine and Public Health; Brockton/West Roxbury VA Medical Center, 940 Belmont Street, Brockton, MA 02401, USA
Get access Rights & Permissions [Opens in a new window]

Abstract

Of 510 patients consecutively admitted and diagnosed as schizophrenic, 310 who failed to meet research criteria for schizophrenia were labelled as having ‘atypical psychosis'. This heterogeneous group of patients was then subtyped into more homogeneous subgroupings according to their clinical characteristics, independent of their family data. One subgroup resembled schizophrenia, one resembled affective disorders and a third (n = 57), which did not resemble either schizophrenia or affective disorder, was defined as ‘schizoaffective’. Comparing the morbidity risks for schizophrenic and affective disorders in the relatives of this schizoaffective group with those of the relatives of ‘typical’ groups of schizophrenia and affective disorder, showed that this group was different from those with schizophrenic and affective disorders.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 158 , Issue 2 , February 1991 , pp. 165 - 170
Copyright
Copyright © Royal College of Psychiatrists, 1991 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
American Psychiatric Association (1987) Diagnosis and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.Google Scholar
Baron, M. Gruen, R. Asnis, L. et al (1982) Schizoaffective illness, schizophrenia and affective disorders: morbidity risk and genetic transmission. Acta Psychiatrica Scandinavica, 65, 253–262.CrossRefGoogle ScholarPubMed
Beck, A. T. (1967) Depression: Cases in Treatment. Philadelphia: University of Pennsylvania Press.Google Scholar
Bleuler, E. (1911) Dementia Praecox oder Gruppe der Schizophrenie. Leipzig: Deuticke.Google Scholar
Bleuler, E. (1924) Textbook of Psychiatry (trans, by Brill, A. A.). New York: Macmillan.Google Scholar
Brockington, I. F. Kendell, R. E. & Wainwright, S. (1980 a) Depressed patients with schizophrenic or paranoid symptoms. Psychological Medicine, 10, 665–675.Google Scholar
Brockington, I. F. Wainwright, S. & Kendell, R. F. (1980 b) Manic patients with schizophrenic or paranoid symptoms. Psychological Medicine, 10, 73–83.Google Scholar
Coble, S. (1953) Progress in internal medicine: review of neuropsychiatry. Archives of Internal Medicine, 92, 273.Google Scholar
Croughan, J. L. Welner, A. & Robins, E. (1974) The group of schizoaffective and related psychoses – critique, record, follow-up, and family studies. II. Record studies. Archives of General Psychiatry, 31, 632–637.Google Scholar
Crow, T. J. (1986) The continuum of psychosis and its implications for the structure of the gene. British Journal of Psychiatry, 149, 419–429.Google Scholar
Engleman, L. (1981) Stepwise logistic regression. In BMDP Statistical Software (ed. Dixon, W.). Berkeley: University of California Press.Google Scholar
Feighner, J. P. Robins, E. Guze, S. B. et al (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.CrossRefGoogle ScholarPubMed
Feinberg, S. E. (1981) The Analysis of Cross-Classified Categorical Data (2nd edn). Cambridge, Massachusetts: MIT Press.Google Scholar
Goode, D. J. & Manning, A. A. (1983) Comparison of buproprion alone with haloperidol in schizoaffective disorder, depressed type. Journal of Clinical Psychiatry, 44, 253–355.Google Scholar
Goodnick, P. J. & Meltzer, H. Y. (1984) Treatment of schizoaffective disorder. Schizophrenia Bulletin, 10, 30–48.Google Scholar
Gross, G. Huber, G. & Armbruster, B. (1986) Schizoaffective psychoses – long-term prognosis and symptomatology. In Schizoaffective Psychoses (eds Marneros, A. & Tsuang, M. T.), pp. 181–203. New York: Springer-Verlag.Google Scholar
Grossman, L. S. Harrow, M. Fudala, J. L. et al (1984) The longitudinal course of schizoaffective disorders. Journal of Nervous and Diseases, 172, 140–149.CrossRefGoogle ScholarPubMed
Harrow, M. & Grossman, L. S. (1984) Outcome in schizoaffective disorders: a critical review and reevaluation of the literature. Schizophrenia Bulletin, 10, 87–108.Google Scholar
Kasanin, J. (1933) The acute schizoaffective psychoses. American Journal of Psychiatry, 13, 92–126.Google Scholar
Levitt, J. J. & Tsuang, M. T. (1988) The heterogeneity of schizoaffective disorder: implications for treatment. American Journal of Psychiatry, 145, 926–936.Google Scholar
Maj, M. (1985) Clinical course and outcome of schizoaffective disorders: a three year follow-up study. Acta Psychiatrica Scandinavica, 72, 542–550.Google Scholar
Mitsuda, H. (ed.) (1967) Clinical Genetics in Psychiatry. Tokyo: Igaku Shoin.Google Scholar
Morrison, J. Clancy, J. Crowe, R. et al (1972) The Iowa 500: I. Diagnostic validity in mania, depression, and schizophrenia. Archives of General Psychiatry, 27, 457–461.CrossRefGoogle ScholarPubMed
Ollerenshaw, D. P. (1973) The classification of the functional psychoses. British Journal of Psychiatry, 122, 517–530.CrossRefGoogle ScholarPubMed
Pope, H. G. & Lipinski, J. F. (1978) Diagnosis in schizophrenia and manic-depressive illness: a reassessment of the specificity of “schizophrenic” symptoms in the light of current research. Archives of General Psychiatry, 35, 811–828.CrossRefGoogle ScholarPubMed
Pope, H. G. & Lipinski, J. F. Cohen, B. N. et al (1980) ‘Schizoaffective disorder’: an invalid diagnosis? A comparison of schizoaffective disorder, schizophrenia, and affective disorder. American Journal of Psychiatry, 137, 921.Google ScholarPubMed
Post, F. (1971) Schizoaffective symptomatology in later life. British Journal of Psychiatry, 118, 437–445.CrossRefGoogle Scholar
Rogers, K. L. & Winokur, G. (1988) The genetics of schizoaffective disorder and the schizophrenia spectrum. In Handbook of Schizophrenia (eds Tsuang, M. T. & Simpson, J. C.). Amsterdam: Elsevier Science Publishers.Google Scholar
Samson, J. A. Simpson, J. C. & Tsuang, M. T. (1988) Outcome studies of schizoaffective disorders. Schizophrenia Bulletin, 14, 543–554.CrossRefGoogle ScholarPubMed
Stephens, M. A. (1974) EDF statistics for goodness of fit and some comparisons. Journal of the American Statistical Association, 69, 730–737.CrossRefGoogle Scholar
Tsuang, M. T. (1979) ‘Schizoaffective disorder’: dead or alive? Archives of General Psychiatry, 36, 633–634.Google Scholar
Tsuang, M. T. & Simpson, J. C. (1984) Schizoaffective disorder: concept and reality. Schizophrenia Bulletin, 10, 14–25.Google Scholar
Tsuang, M. T. & Fleming, J. A. (1986) Long-term outcome of schizophrenia and other psychoses. In Search for the Causes of Schizophrenia (ed. H. Hafner), pp. 88–97. Heidelberg: University of Heidelberg.Google Scholar
Tsuang, M. T. Woolson, R. F. & Fleming, J. A. (1979) Long-term outcome of major psychoses: I. Schizophrenia and affective disorder compared with psychiatrically symptom-free surgical conditions. Archives of General Psychiatry, 36, 1295–1301.Google Scholar
Tsuang, M. T. Woolson, R. F. & Simpson, J. C. (1980 a) The Iowa structured psychiatric interview: rationale, reliability, and validity. Acta Psychiatrica Scandinavica, 62 (suppl. 283), 7–26.Google Scholar
Tsuang, M. T. Winokur, G. & Crowe, R. R. (1980 b) Morbidity risks of schizophrenia and affective disorders among first-degree relatives of patients with schizophrenia, mania, depression and surgical conditions. British Journal of Psychiatry, 137, 497–504.Google Scholar
Welner, A. Croughan, J. L. Fishman, R. et al (1977) The group of schizoaffective and related psychoses: a follow-up study. Comprehensive Psychiatry, 20, 413–422.Google Scholar
Welner, A. Welner, Z. & Fishman, R. (1979) The group of schizoaffective and related psychoses: IV. A family study. Comprehensive Psychiatry, 20, 21–26.Google Scholar
Zerbin-Rüdin, E. (1986) Schizoaffective and other atypical psychoses: the genetic aspect. In Schizoaffective Psychoses (eds A. Marneros & M. T. Tsuang). Berlin: Springer-Verlag.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.