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Mood Change following Bilateral Hemisphere Brain Injury

Published online by Cambridge University Press:  29 January 2018

John R. Lipsey ,
Robert G. Robinson ,
Godfrey D. Pearlson ,
Krishan Rao  and
Thomas R. Price
John R. Lipsey
Affiliation:
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Robert G. Robinson
Affiliation:
Johns Hopkins University School of Medicine
Godfrey D. Pearlson
Affiliation:
Johns Hopkins University School of Medicine
Krishan Rao
Affiliation:
University of Maryland School of Medicine, Baltimore, Maryland 21201
Thomas R. Price
Affiliation:
University of Maryland School of Medicine
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Summary

Fifteen patients with bilateral hemisphere brain injury secondary to thromboembolic stroke or trauma were evaluated for depression, cognitive impairment, and functional physical impairment. Analysis of CT scans and standardized mood scales revealed that patients with left anterior brain injury were significantly more depressed than patients without such injury. Depression severity was directly and significantly correlated with left lesion proximity to the frontal pole. Left lesion age, lesion temporal sequence, right lesion location, cognitive impairment, and functional physical impairment did not significantly correlate with depression. Depressive symptomatology previously shown to be associated with single left frontal lobe lesions appeared to dominate post-brain injury psychopathology regardless of location or temporal sequence of other brain lesions.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 143 , Issue 3 , September 1983 , pp. 266 - 273
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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