Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-22T16:24:12.106Z Has data issue: false hasContentIssue false
  • English
  • Français

Monoamine Oxidase (Mao) of Platelets, Plasma, Lymphocytes and Granulocytes in Schizophrenia

Published online by Cambridge University Press:  29 January 2018

Peter A. Bond ,
Richard L. Cundall  and
Ian R. H. Falloon
Peter A. Bond
Affiliation:
University of Southern California
Richard L. Cundall
Affiliation:
University of Southern California
Ian R. H. Falloon
Affiliation:
University of Southern California
Get access Rights & Permissions [Opens in a new window]

Summary

Monoamine oxidase (MAO) levels in plasma, platelets, lymphocytes and granulocytes have been compared in schizophrenics and controls using three substrates. No significant difference was found between MAO levels in controls and the schizophrenic group as a whole, but platelets and lymphocytes of the latter (tyramine or benzylamine substrate) showed greater variation and in some cases higher values than controls, irrespective of treatment. Schizophrenics who experienced auditory hallucinations had significantly lower MAO levels in lymphocytes and platelets than those who did not.

Type
Papers
Information
The British Journal of Psychiatry , Volume 134 , Issue 4 , April 1979 , pp. 360 - 365
Copyright
Copyright © Royal College of Psychiatrists, 1979 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Belmaker, R., Murphy, D. L., Wyatt, R. J. & Loriaux, L. (1974) Human platelet monoamine oxidase changes during the menstrual cycle. Archives of General Psychiatry, 31, 553–6.Google Scholar
Berger, P. A., Ginsburg, R. A., Barchas, J. D., Murphy, D. L. & Wyatt, R. J. (1978) Platelet monoamine oxidase in chronic schizophrenic patients. American Journal of Psychiatry, 135, 95–9.Google Scholar
Bond, P. A. & Cundall, R. L. (1977) Properties of monoamine oxidase (MAO) in human blood platelets, plasma, lymphocytes and granulocytes. Clinica Chimica Acta, 80, 317–26.CrossRefGoogle ScholarPubMed
Boyum, A. (1974) Separation of blood leucocytes, granulocytes and lymphocytes. Tissue Antigens, 4, 269–74.Google Scholar
Brockington, I., Crow, T. J., Johnstone, E. C. & Owen, F. (1976) An investigation of platelet monoamine oxidase activity. In Schizophrenia and Schizoaffective Psychosis. CIBA Foundation Symposium, 39, 353–69.Google Scholar
Friedman, E., Shopsin, B., Sathananthan, G. & Gershon, S. (1974) Blood platelet monoamine oxidase activity in psychiatric patients. American Journal of Psychiatry, 131, 1392–4.Google Scholar
Meltzer, H. Y. & Stahl, S. M. (1974) Platelet monoamine oxidase activity and substrate preferences in schizophrenic patients. Research Communications in Chemical Pathology and Pharmacology, 7, 419–31.Google Scholar
Murphy, D. L. & Wyatt, R. J. (1972) Reduced monoamine oxidase activity in blood platelets from schizophrenic patients. Nature (London), 238, 225–6.Google Scholar
Murphy, D. L., Belmaker, R., Carpenter, W. T. & Wyatt, R. J. (1977) Monoamine oxidase in chronic schizophrenia. Studies of hormonal and other factors affecting enzyme activity. British Journal of Psychiatry, 130, 151–8.Google Scholar
Murphy, D. L., Donnelly, C. H., Miller, L. & Wyatt, R. J. (1976) Platelet monoamine oxidase in schizophrenia. Some enzyme characteristics relevant to reduced activity. Archives of General Psychiatry, 33, 1377–81.Google Scholar
Nies, A., Robinson, D. S., Harris, L. S. & Lamborn, K. R. (1974) Comparison of monoamine oxidase substrate activities in twins, schizophrenics, depressives and controls. In Neuropsychopharmacology of Monoamines and their Regulatory Enzymes. 59–70. Raven Press.Google Scholar
Owen, F., Bourne, R., Crow, T. J., Johnstone, E. C., Bailey, A. R. & Hershon, H. I. (1976) Platelet monoamine oxidase in schizophrenia. Archives of General Psychiatry, 33, 1370–3.Google Scholar
Owen, F., Cookson, I. B. & Ridges, A. P. (1974) Monoamine oxidase activity—a genetic marker for schizophrenia? Acta Geneticae Medicae et Gemellologiae, 23, 371–6.Google Scholar
Robinson, D. S., Lovenberg, W., Keiser, H. & Sjoerdoma, A. (1968) Effects of drugs on human blood platelets and plasma amine oxidase in vitro and in vivo. Biochemical Pharmacology, 17, 109–19.Google Scholar
Sandler, M. & Youdim, M. B. H. (1972) Multiple forms of monoamine oxidase functional significance. Pharmacological Reviews, 24, 331–49.Google Scholar
Schildkraut, J. J., Herzog, J. M., Orsulak, P. J., Edelman, S. E., Shein, H. M. & Frazier, S. H. (1976) Reduced platelet monoamine oxidase activity in a subgroup of schizophrenic patients. American Journal of Psychiatry, 133, 438–40.Google Scholar
Schildkraut, J. J., Orsulak, P. J., Schalzberg, A. F., Cole, J. O., Gudeman, J. E. & Rohde, W. A. (1978) Elevated platelet monoamine oxidase activity in schizophrenia—related depressive disorders. American Journal of Psychiatry, 135, 110–12.Google ScholarPubMed
Schneider, K., (1959) Clinical Psychopathology. New York: Grune & Stratton.Google Scholar
Shaskan, E. G. & Becker, R. E. (1975) Platelet monoamine oxidase in schizophrenics. Nature, 253, 659–60.Google Scholar
Tipton, K. F. & Youdim, M. B. H. (1976) Assay of monoamine oxidase. CIBA Foundation Symposium, 39, 393–403.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. Cambridge University Press.Google Scholar
Youdim, M. B. H. (1976) Preparation of human platelets. CIBA Foundation Symposium, 39, 405–6.Google Scholar
Youdim, M. B. H., Woods, H. F., Grahame-Smith, D. G., Mitchell, B. & Callender, S. (1975) Human platelet monoamine oxidase activity in iron-deficiency anaemia. Clinical Science and Molecular Medicine, 48, 289–95.Google Scholar
Young, D. S. & Hicks, J. M. (1965) Method for the automatic determination of serum iron. Journal of Clinical Pathology, 18, 98–102.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.