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Mode of Inheritance as Indicated by One-sided and Two-sided Familial Taint: with an Application to Schizophrenia

Published online by Cambridge University Press:  02 January 2018

Erik Essen-Möller  and
Jan Lanke
Erik Essen-Möller*
Affiliation:
Docent, Department of Statistics, University of Lund
Jan Lanke
Affiliation:
Docent, Department of Statistics, University of Lund
*
Alsbäck 3186, S-453 00 Lysekil, Sweden
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Abstract

Among his various approaches to an understanding of schizophrenic inheritance, whether dominant or recessive, Rüdin (1916) also compared the respective frequencies of one-sided and two-sided familial taint. Essen-Möller (1949) tried the idea on another sample, but neither of us arrived at a definite choice. Lateron Slater (1966) surprisingly demonstrated that unilaterality is typical not only of dominant but also of polygenic transmission. In the present paper we adjust Slater's computation and, in so doing, accentuate his result. We also find a similar preponderance of unilaterality on a recessive model, and offer an explanation for this. The findings substantially reduce the efficacy of laterality of taint as an indicator of mode of inheritance.

Type
Papers
Information
The British Journal of Psychiatry , Volume 151 , Issue 6 , December 1987 , pp. 766 - 772
Copyright
Copyright © Royal College of Psychiatrists, 1987 

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Footnotes

For reprints: The Secretary, Department of Psychiatry Lasarettet, S-221 85 Lund, Sweden

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