Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-05T04:30:37.428Z Has data issue: false hasContentIssue false
  • English
  • Français

Midline brain anomalies and schizophrenia in people with CATCH 22 syndrome

Published online by Cambridge University Press:  03 January 2018

R. Vataja  and
Eero Elomaa
R. Vataja*
Affiliation:
Department of Psychiatry, Helsinki University Hospital, Helsinki, Finland
Eero Elomaa
Affiliation:
Kellokoski Hospital, Finland
*
Dr R. Vataja, Helsinki University Hospital, Department of Psychiatry, Lapinlahdentie, 00290 Helsinki, Finland
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

Since people with chromosome 22q11 deletion (CATCH 22 syndrome) have unexpectedly high incidence of major psychosis it has been suggested that 22q area might be involved in the pathogenesis of schizophrenia and bipolar disorders.

Method

A single case report.

Results

A 32-year-old male patient with CATCH 22 syndrome and schizophrenia had extensive midline anomalies of the brain in the regions relevant to psychotic disorders.

Conclusions

22q11-dependent abnormalities in the midline structures of the brain may cause dysfunction in the limbic system and interfere with the interhemispheric information exchange thus predisposing people with CATCH 22 syndrome to psychotic disorders.

Type
Papers
Information
The British Journal of Psychiatry , Volume 172 , Issue 6 , June 1998 , pp. 518 - 520
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Honer, W. G. Basset, A. S. Macewan, W. et al (1992) Structural brain imaging abnormalities associated with schizophrenia and partial trisomy of chromosome 5. Psychological Mediane, 22, 519–524.Google Scholar
Lewis, S. W. & Mezey, G. C. (1985) Clinical correlates of septum pellucidum cavities: an unusual association with psychosis. Psychological Medicine, 15, 43–54.CrossRefGoogle ScholarPubMed
Lammer, E. J. & Opitz, J. M. (1986) The DiGeorge anomaly as a developmental field defect. American Journal of Medical Genetics, 2 (suppl. 2), 113–127.Google Scholar
Martin, P. & Alber, M. (1995) Cerebellum and schizophrenia: a selective review. Schizophrenia Bulletin, 21, 241–250.Google Scholar
Mitnick, R. J. Bello, J. A. & Shprintzen, R. J. (1994) Brain anomalies in velo-cardio-facial syndrome. American Journal of Medical Genetics, 54, 100–106.Google Scholar
Murphy, K. C. & Owen, M. J. (1996) Schizophrenia. CATCH 22 and FISH. British Journal of Psychiatry, 168, 397–398.Google Scholar
Papolos, D. F. Faedda, G. L. Veit, S. et al (1996) Bipolar spectrum disorders in patients with velo-cardiofacial syndrome: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder? American Journal of Psychiatry, 153, 1541–1547.Google Scholar
Sarwar, M. (1989) The septum pellucidum: normal and abnormal. American Journal of Neuroradiology, 10, 989–1005.Google ScholarPubMed
Wilson, D. L. Burn, J. Scambler, P. et al (1993) Syndrome of the month. DiGeorge syndrome, part of CATCH 22. Journal of Medical Genetics, 30, 852–856.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.