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Methodological Problems of Prophylactic Trials in Recurrent Affective Disorders

Published online by Cambridge University Press:  29 January 2018

P. Grof ,
M. Schou ,
J. Angst ,
P. C. Baastrup  and
P. Weis
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Extract

During the past year the question of lithium prophylaxis has been the subject of lively debate (Blackwell and Shepherd, 1968; Hullin et al., 1968; Houghton, 1968; Baastrup and Schou, 1968a; Lader, 1968; Sargant, 1968; Saran, 1968; Baastrup and Schou, 1968b; Melia, 1968; Fieve and Platman, 1968; Cole, 1968; Kline, 1968; Kerry, 1968; Editorial, 1968; Berlyne, 1968; Silverman, 1968; Laurell and Ottosson, 1968; Lancet Editorial, 1969; Whybrow, 1969; Melia, 1969; Angst et al., 1969c). This discussion has revealed considerable uncertainty about the design and assessment of prophylactic trials, and there have been misunderstandings on important points.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 116 , Issue 535 , June 1970 , pp. 599 - 603
Copyright
Copyright © Royal College of Psychiatrists, 1970 

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