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Metabolism of Phenothiazine and Butyrophenone Antipsychotic Drugs

A Review of some Recent Research Findings and Clinical Implications

Published online by Cambridge University Press:  06 August 2018

J. W. Hubbard ,
K. K. Midha ,
E. M. Hawes ,
G. McKAY ,
S. R. Marder ,
M. Aravagiri  and
E. D. Korchinski
J. W. Hubbard
Affiliation:
College of Pharmacy, University of Saskatchewan
K. K. Midha*
Affiliation:
Colleges of Pharmacy and Medicine, University of Saskatchewan and UCLA/Clinical Research Center for Schizophrenia & Psychiatric Rehabilitation, and the Psychopharmacology Laboratory, West Los Angeles Veteran's Affairs Medical Center
E. M. Hawes
Affiliation:
College of Pharmacy, University of Saskatchewan
G. McKAY
Affiliation:
College of Pharmacy, University of Saskatchewan
S. R. Marder
Affiliation:
UCLA/Clinical Research Center for Schizophrenia & Psychiatric Rehabilitation, and the Psychopharmacology Laboratory, West Los Angeles Veteran's Affairs Medical Center
M. Aravagiri
Affiliation:
UCLA/Clinical Research Center for Schizophrenia & Psychiatric Rehabilitation, and the Psychopharmacology Laboratory, West Los Angeles Veteran's Affairs Medical Center
E. D. Korchinski
Affiliation:
College of Pharmacy/Medicine, University of Saskatchewan
*
∗College of Pharmacy, University of Saskatchewan, Saskatoon, Saskatchewan S7N 0W0, Canada
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Abstract

Whereas some metabolites of antipsychotic drugs are psychoactive and contribute to clinical improvement, recent studies have provided evidence that certain metabolites contribute to side-effects which can be disabling enough to negate clinical improvement as regards the psychosis. The route of administration of the drug can determine the amount of metabolite produced in the body and affect how the patient feels in response to the treatment.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 163 , Issue S22: The Psychopharmacology of Schizophrenia , December 1993 , pp. 19 - 24
Copyright
Copyright © 1993 The Royal College of Psychiatrists 

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