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A Mechanism to Inhibit Input Activation and its Dysfunction in Schizophrenia

Published online by Cambridge University Press:  29 January 2018

J. David Johnson*
Affiliation:
106 North East Street, Eaton Rapids, Michigan, 48827, USA

Summary

Schizophrenics appear to be unable to regulate adequately the effects of external stimulation, but the cause of this deficit is unclear. Recent evidence suggests that input activation can normally be inhibited by an appropriate leading or conditioning stimulus; such inhibition has been found to be diminished in schizophrenics. Based on this evidence, a feed-forward regulating mechanism that serves to stabilise reactivity to environmental events is described; it is hypothesised that failure of the mechanism to inhibit adequately surges of activity is an underlying cause of schizophrenic symptoms. Some ways to test the validity of the mechanism are proposed, and an outline presented of steps to link the mechanism's dysfunction to schizophrenia.

Type
Research Article
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

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References

Adler, L. E., Pachtman, E., Franks, R. D., Pecevich, M., Waldo, M. C. & Freedman, R. (1982) Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biological Psychiatry, 17, 639654.Google Scholar
Braff, D. L., Callaway, E. & Naylor, H. (1977) Very short-term memory dysfunction in schizophrenia. Archives of General Psychiatry, 34, 2530.Google Scholar
Braff, D. L., Stone, C., Callaway, E., Geyer, M., Glick, I. & Likh, B. (1978) Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology, 15, 339343.Google Scholar
Broadbent, D. E. (1958) Perception and Communication. London: Pergamon Press.CrossRefGoogle Scholar
Broadbent, D. E. (1971) Decision and Stress. London: Academic Press.Google Scholar
Broen, W. E. (1973) Limiting the flood of stimulation: A protective deficit in chronic schizophrenia. In Contemporary Issues in Cognitive Psychology (ed. Solso, R. L.). Washington, D.C.: Winston.Google Scholar
Chapman, L. J., Chapman, J. P. & Raulin, M. L. (1978) Body-image aberration in schizophrenia. Journal of Abnormal Psychology, 87, 399407.Google Scholar
Chapman, L. J. & Taylor, J. (1957) Breadth of deviate concepts used by schizophrenics. Journal of Abnormal and Social Psychology, 54, 118123.Google Scholar
Franks, R. D., Adler, L. E., Waldo, M. C., Alpert, J. & Freedman, R. (1983) Neurophysiological studies of sensory gating in mama: comparison with schizophrenia. Biological Psychiatry, 18, 9891005.Google Scholar
Freedman, R., Adler, L. E., Waldo, M. C., Pachtman, E. & Franks, R. D. (1983) Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug-free patients. Biological Psychiatry, 18, 537551.Google Scholar
Gjerde, P. F. (1983) Attentional capacity dysfunction and arousal in schizophrenia. Psychological Bulletin, 93, 5772.Google Scholar
Graham, F. K. (1975) The more or less startling effects of weak prestimulation. Psychophysiology, 12, 238248.Google Scholar
Gruzelier, J. H. (1978) Bimodal states of arousal and lateralized dysfunction in schizophrenia. In The Nature of Schizophrenia (eds. Wynne, L. C., Cromwell, R. & Matthysse, S.). New York: Wiley.Google Scholar
Hemsley, D. R. (1975) A two-stage model of attention in schizophrenia research. British Journal of Social and Clinical Psychology, 14, 8189.Google Scholar
Hoffman, H. S. & Ison, J. R. (1980) Reflex modification in the domain of startle. Psychological Review, 87, 175189.Google Scholar
Kahneman, D. (1973) Attention and Effort. Englewood Cliffs, N.J.: Prentice-Hall.Google Scholar
Landis, C. & Hunt, W. A. (1939) The Startle Pattern. New York: Farrar and Rinehart.Google Scholar
Lawson, J. S., McGhie, A. & Chapman, J. (1967) Distractibility in schizophrenic and organic cerebral disease. British Journal of Psychiatry, 113, 527535.Google Scholar
Marshall, W. L. (1973) Cognitive functioning in schizophrenia. British Journal of Psychiatry, 123, 413433.Google Scholar
McGhie, A. & Chapman, J. (1961) Disorders of attention and perception in early schizophrenia. British Journal of Medical Psychology, 34, 103116.CrossRefGoogle ScholarPubMed
Peschon, J., Pun, L. & Mitter, S. K. (1965) Computer process control. In Disciplines and Techniques of Systems Control (ed. Peschon, J.). New York: Blaisdell Publishing Company.Google Scholar
Reiter, L. A. & Ison, J. R. (1977) Inhibition of the human eyeblink reflex: an examination of the Wendt-Yerkes method for threshold detection. Journal of Experimental Psychology: Human Perception and Performance, 3, 325336.Google Scholar
Rijusdorp, J. E. (1961) Single and multiple loop controls. In Handbook of Automation, Computation, and Control Vol. 3 (eds. Grabbe, E. M., Ramo, S. & Wooldridge, D. E.). New York: John Wiley and Sons, Inc.Google Scholar
Schafer, E. W. P. & Marcus, M. M. (1973) Self-stimulation alters human sensory brain responses. Science, 181, 175177.Google Scholar
Schneider, S. J. (1978) Speculating about cognitive experiments using schizophrenics. Schizophrenia Bulletin, 4, 483486.Google Scholar
Shagass, C. (1976) An electrophysiological view of schizophrenia. Biological Psychiatry, 11, 329.Google Scholar
Shagass, C. (1979) Possible contributions of evoked potentials to the vulnerability hypothesis. Psychopharmacology Bulletin, 15, 3436.Google Scholar
Shagass, C. Roemer, R. A., Straumanis, J. J. & Amadeo, M. (1978) Evoked potential correlates of psychosis. Biological Psychiatry, 13, 163184.Google Scholar
Silverman, J. (1972) Stimulus intensity modulation and psychological dis-ease. Psychopharmacologia, 24, 4280.Google Scholar
Silverstein, L. D. & Graham, F. K. (1979) Orbicularis oculi excitability and prestimulation effects during REM and NREM sleep. Psychophysiology, 16, 177.Google Scholar
Sperry, R. W. (1950) Neural basis of the spontaneous optokinetic response produced by visual inversion. Journal of Comparative and Physiological Psychology, 43, 482489.Google Scholar
Venables, P. H. (1964) Input dysfunction in schizophrenia. In Progress in Experimental Personality Research Vol. 1 (ed. Maher, B. A.). New York: Academic Press.Google Scholar
Venables, P. H. (1977) Postscript to “Input dysfunction in schizophrenia”. In Contributions to the Psychopathology of Schizophrenia (ed. Maher, B. A.). New York: Academic Press.Google Scholar
Von Holst, E. (1954) Relations between the central nervous system and the peripheral organs. British Journal of Animal Behavior, 2, 8994.Google Scholar
Zahn, T. P. (1975) Psychophysiological concomitants of task performance in schizophrenia. In Experimental Approaches to Psychopathology (eds. Kietzman, M. L., Sutton, S. & Zubin, J.). New York: Academic Press.Google Scholar
Zahn, T. P., Carpenter, W. T. & McGlashan, T. H. (1981) Autonomic nervous system activity in acute schizophrenia. I. Method and comparison with normal controls. Archives of General Psychiatry, 38, 251259.Google Scholar
Zeigler, B. L. & Graham, F. K. (1979) Developmental differences in processing of transient and sustained stimulation. Psychophysiology, 16, 177178.Google Scholar
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