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Low CSF Concentrations of Cyclic GMP in Schizophrenia

Published online by Cambridge University Press:  29 January 2018

W. F. Gattaz ,
H. Cramer  and
H. Beckmann
W. F. Gattaz*
Affiliation:
Faculdade de Medicina da Fundacao do ABC (Brazil) and Visiting Professor, Central Institute of Mental Health, Mannheim, F.R. Germany
H. Cramer
Affiliation:
Department of Neurology, University of Freiburg, F.R. Germany
H. Beckmann
Affiliation:
The Central Institute of Mental Health—Mannheim, F.R. Germany
*
∗Correspondence and reprint requests: R. Leoncio de Carvalho 254 04003 Sao Paulo-S.P.-Brazil.
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Summary

Increasing evidence suggests that the concentrations of cyclic guanosine 3′5′-monophosphate (cGMP) in the cerebrospinal fluid (CSF) may reflect central cholinergic activity. When the concentrations of this nucleotide in the CSF from 28 schizophrenic patients (13 without and 15 with neuroleptic treatment) and 16 psychiatrically healthy controls was determined the schizophrenics showed significantly lower CSF levels of cGMP as compared to controls.

As dopamine and homovanillic acid concentrations were not altered in these CSF samples, this finding of reduced cGMP suggests a cholinergic-dopaminergic imbalance in schizophrenia, with a reduction of the former and consequently a relative dominance of the latter.

Type
Papers
Information
The British Journal of Psychiatry , Volume 142 , Issue 3 , March 1983 , pp. 288 - 291
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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