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Long-Term Administration of Tianeptine in Depressed Patients after Alcohol Withdrawal

Published online by Cambridge University Press:  06 August 2018

R. Malka ,
H. Lôo ,
H. Ganry ,
A. Souche ,
C. Marey  and
A. Kamoun
R. Malka
Affiliation:
Centre Gilbert Raby, Meulan et Institut de Psychiatrie La Rochefoucault, Paris, France
H. Lôo
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Hôpital Sainte Anne, Paris, France
H. Ganry
Affiliation:
Institut de Recherches Internationales Servier, Courbevoie, France
A. Souche
Affiliation:
Hôpital de Malevoz, Monthey, Switzerland
C. Marey
Affiliation:
Institut de Recherches Internationales Servier, Courbevoie, France
A. Kamoun
Affiliation:
Institut de Recherches Internationales Servier, 6 place des Pleiades, 92415 Courbevoie, Cedex, France
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Extract

Alcohol interferes with the central metabolism of the catecholamines and especially with indolamines (5-HT). Thus, the use of an antidepressant such as tianeptine, whose main neurochemical effect is to increase the reuptake of 5-HT, seems to be particularly indicated for the continued treatment of depressed patients after alcohol withdrawal. This study evaluated the therapeutic efficacy and acceptability during long-term administration of tianeptine in depressed patients (major depressive episode or dysthymic disorder) in a multicentre trial, after withdrawal from alcohol abuse or dependence. The results relate to 130 depressed patients, who abstained from alcohol and received treatment for a year. Only one patient dropped-out because of side-effects, and medication was interrupted in 5% of subjects because of alcoholic relapses. Prescribed in the long term, tianeptine did not produce orthostatic hypotension, changes in bodyweight, or alterations in the ECG. All changes found in haematological and biochemical investigations suggested an improvement in patients' physical state. This, and other studies, indicate that tianeptine appears to have the potential to be a safe antidepressant, which might be particularly useful in those patients who are susceptible to the side-effects of psychotropic drugs.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 160 , Issue S15: Stress, Serotonin and Tianeptine , February 1992 , pp. 66 - 71
Copyright
Copyright © The Royal College of Psychiatrists 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
Angst, J., Bech, P., Boyer, P., et al (1989) Consensus conference on the methodology of clinical trials of antidepressants. Report of the Consensus Committee. Pharmacopsychiatry, 22, 3–7.CrossRefGoogle Scholar
Badawy, A. A. B., Punjani, N. F., Evans, C. M., et al (1980) Inhibition of rat brain tryptophan metabolism by ethanol withdrawal and possible involvement of the enhanced liver tryptophan pyrrolase activity. Biochemical Journal, 192, 449–455.CrossRefGoogle ScholarPubMed
Ballenger, J. C., Goodwin, F. K., Major, L. F., et al (1979) Alcohol and central serotonin metabolism in man. Archives of General Psychiatry, 36, 226–227.Google Scholar
Bersani, G., Pasini, A., Brancato, T., et al (1989) Serotonina e depressione: studio multricentrico controllato tianeptina versus amitriptilina. XXXVII Congresso Nazionale della Societa Italiana di Psichiatria. Roma (CIC Edizioni Internazionali), 1243–1249.Google Scholar
Davis, V. E., Brown, H., Huff, J. A., et al (1967) The alterations of serotonin metabolism to 5-hydroxytryptophol by ethanol ingestion in man. Journal of Laboratory and Clinical Medicine, 69, 132–140.Google ScholarPubMed
Delalleau, B., Dulcire, C., Le Moine, P., et al (1988) Analysis of the side effects of tianeptine. Clinical Neuropharmacology, 11 (suppl. 2), S83–S89.Google Scholar
Derogatis, C. R., Lipman, R. S., Rickels, K., et al (1974) The Hopkins Symptom Checklist (HSCL): a self-report symptom inventory. Behavioral Science, 19, 1–15.Google Scholar
De Simoni, M. G., De Luigi, A., Manfridi, A., et al (1989) Tianeptine enhancement of serotonin uptake: an in vivo voltametric study. Book of Abstracts, International Symposium on Serotonin from Cell Biology to Pharmacology and Therapeutics, Florence, 87.Google Scholar
Feighner, J. P., Aden, G. C., Fabre, L. F., et al (1983) Comparison of alprazolam, imipramine and placebo in the treatment of depression. Journal of the American Medical Association, 249, 3057–3064.Google Scholar
Galinowksi, A., Olie, J. P., Guelfi, J. D., et al (1988) Interest of long-term antidepressant therapy. Experience with tianeptine: a new antidepressant. Abstracts of the XVIth CINP Congress Munich. Psychopharmacology, 96 (suppl.) 11.31.11.Google Scholar
Gay, C., Benkelfat, C. & Renardet, M. (1986) Utilisation de la télématique dans les essais cliniques de phase IV. Une étude nationale avec la trazodone sur 1946 patients déprimés. Actualités Psychiatriques, 4, 81–96.Google Scholar
Glassman, A. H. & Bigger, J. T. (1981) Cardiovascular effects of therapeutic doses of tricyclic antidepressants. Archives of General Psychiatry, 38, 815–820.CrossRefGoogle ScholarPubMed
Guelfi, J. D., Dreyfus, J. F. & Pull, C. B. (1983) A check list for the assessment of somatic symptoms (CHESS). Book of Abstracts, Proceedings of the 7th World Congress Psychiatry, Vienna, July.Google Scholar
Guelfi, J. D., Pichot, P. & Dreyfus, J. F. (1989) Efficacy of tianeptine in anxious-depressed patients: results of a controlled multicenter trial versus amitriptyline. Neuropsychobiology, 22, 41–48.Google Scholar
Guy, W. (1976) ECDEU Assessment Manual for Psychopharmacology. Washington, DC: US Department of Health Education and Welfare.Google Scholar
Hamilton, M. (1959) The assessment of anxiety states by rating. British Journal of Psychology, 32, 50–55.Google Scholar
Kato, G. & Weitsch, A. F. (1988) Neurochemical profile of tianeptine, a new antidepressant drug. Clinical Neuropharmacology, 11 (suppl. 2), S43–S50.Google ScholarPubMed
Labrid, C., Moleyre, J., Poignant, J. C., et al (1988) Structure-activity relationships of tricyclic antidepressant with special reference to tianeptine. Clinical Neuropharmacology, 11 (suppl. 2), S21–S31.Google ScholarPubMed
Lejeune, F., Poignant, J. C. & Reure, H. (1988) Etude électro-physiologique de la tianeptine, nouveau stimulant du recaptage de la sérotonine possédant une activité antidépressive. Neurophysiologie Clinique, 18, 369–381.CrossRefGoogle Scholar
Lôo, H., Zarifian, E. & Kamoun, A. (1981) Place de la tianeptine parmi les antidépresseurs. In Proceedings of the Third World Congress of Biological Psychiatry, Stockholm (eds Perris, C., Struwe, G. & Jansson, B.), pp. 609–612. Amsterdam: Elsevier.Google Scholar
Lôo, H. & Olié, J. P. (1984) Problèmes liès à l'arrět des antidépresseurs et du lithium. Thérapie, 39, 403–410.Google Scholar
Lôo, H. & Deniker, P. (1988) Position of tianeptine among antidepressive chemotherapies. Clinical Neuropharmacology, 11 (suppl. 2), S97–S102.Google ScholarPubMed
Lôo, H., Malka, R., Defrance, R., et al (1988) Tianeptine and amitriptyline: controlled double blind trial in depressed alcholic patients. Neuropsychobiology, 19, 79–85.Google Scholar
Malka, R. (1988) Role of drug therapies in the treatment of alcoholism: alcohol and anxiety – alcohol and depression. Clinical Neuropharmacology, 11 (suppl. 2), S69–S73.Google ScholarPubMed
Malka, R., Fouquet, P. & Vachonfrance, G. (1986) Alcoologie. (Masson édit.), 190 p.Google Scholar
Malka, R. & Lôo, H. (1988) Place des psychotropes dans la prise en charge des alcooliques. Concours Médical, 110, 2453–2457.Google Scholar
Mendels, J. & Schless, A. P. (1986) Comparative efficacy of alprazolam, imipramine and placebo administered once a day in treating depressed patients. Journal of Clinical Psychiatry, 47, 357–361.Google Scholar
Mennini, T., Mocaër, E. & Garattini, S. (1987) Tianeptine, a selective enhancer of serotonin uptake in rat brain. Naunyn Schmiedeberg's Archives of Pharmacology, 336, 478–482.Google Scholar
Merikangas, K. R., Leckman, J. F., Prusoff, B. A., et al (1985) Familial transmission of depression and alcoholism. Archives of General Psychiatry, 42, 367–372.Google Scholar
Mocaër, E., Rettori, M. C. & Kamoun, A. (1988) Pharmacological antidepressive effects and tianeptine-induced 5-HT uptake increase. Clinical Neuropharmacology, 11 (suppl. 2), S32–S42.Google Scholar
Montgomery, S. A. & Åsberg, M. (1979) A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382–389.Google Scholar
Olié, J. P., Guelfi, J. D., Malka, R., et al (1988) Traitement de longue durée par les antidépresseurs. La tianeptine: méthodologie d'une étude au long cours et résultats préliminaries. Encéphale, 14, 379–384.Google Scholar
Ostaptzeff, G. (1981) Etude contrôlée à double insu versus imipramine de l'efficacité de la tianeptine dans les états dépressifs non psychotiques. In Proceedings of the Third World Congress of Biological Psychiatry, Stockholm in Proceedings of the Third World Congress of Biological Psychiatry, Stockholm (eds Perris, C., Struwe, G. & Jansson, B.), pp. 597–600. Amsterdam: Elsevier.Google Scholar
Prien, R. F. (1987) Long-term treatment of affective disorders. In Psychopharmacology: the Third Generation of Progress (ed. Meltzer, H. Y.), pp. 1051–1058. New York: Raven Press.Google Scholar
Renaud, B., Mocaër, E., Weitsch, A. F., et al (1988) Stimulation of serotonin uptake induced by a new antidepressant. (Proceeding of the ECNP constitutent meeting, Brussels). Pharmacopsychiatry, 21, 66.Google Scholar
Weiss, C., Gorceix, A., Kindynis, S., et al (1981) Etude contrôlée à double insu versus nomifensine de l'activité et du délai d'action d'un nouvel antidépresseur: la tianeptine. In Proceedings of the Third World Congress of Biological Psychiatry, Stockholm in Proceedings of the Third World Congress of Biological Psychiatry, Stockholm (eds Perris, C., Struwe, G., Jansson, B.), pp. 593–596. Amsterdam: Elsevier.Google Scholar
Weissman, M. M. & Myers, J. K. (1980) Clinical depression in alcoholism. American Journal of Psychiatry, 137, 372–373.Google Scholar
Weitsch, A. F., Mocaër, E. & Kato, G. (1986) Tianeptine: a new antidepressant which increases serotonin uptake. Book of abstracts–Poster Sessions of the 15th Collegium Internationale Neuropsychopharmacologicum Congress, San Juan, Porto-Rico, p. 241.Google Scholar
Winokur, G. (1979) Alcoholism and depression in the same family. In Alcoholism and Affective Disorders: Clinical, Genetic and Biochemical Studies (eds Goodwin, D. W. & Erickson, P.), pp. 49–56. New York: S.P. Medical and Scientific Books.Google Scholar
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