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Localisation of a Susceptibility Locus for Schizophrenia on Chromosome 5

Published online by Cambridge University Press:  02 January 2018

Michael Owen ,
David Craufurd  and
David St Clair
Michael Owen
Affiliation:
Department of Psychological Medicine and Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff
David Craufurd
Affiliation:
Department of Medical Genetics, St Mary's Hospital, Hathersage Road, Manchester M13 0JH
David St Clair
Affiliation:
University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF
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Abstract

“A considerable proportion of the variance in the liability to develop schizophrenia may be genetic, but segregation analysis, to establish a mode of transmission, has not produced a consistent result. One of these studies was carried out in Iceland and made use of the large family size and extensive genealogical information present in that country. Here we demonstrate genetic linkage of two DNA polymorphisms on the long arm of human chromosome 5 to schizophrenia in seven British and Icelandic families with multiple affected members. The results indicate the existence of a gene locus with a dominant schizophrenia-susceptibility allele. Inheritance of the allele in the families studied suggests that it may also predispose to psychiatric conditions such as schizophrenia spectrum disorders and a variety of other disorders. This report provides the first strong evidence for the involvement of a single gene in the causation of schizophrenia.”

Type
The Current Literature
Information
The British Journal of Psychiatry , Volume 157 , Issue 1 , July 1990 , pp. 123 - 127
Copyright
Copyright © The Royal College of Psychiatrists 

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