Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-31T15:22:18.144Z Has data issue: false hasContentIssue false
  • English
  • Français

Lithium Toxicity and Mefenamic Acid

A Possible Interaction and the Role of Prostaglandin Inhibition

Published online by Cambridge University Press:  02 January 2018

R. K. Shelley
R. K. Shelley*
Affiliation:
University of Dublin, Trinity College
*
Department of Psychiatry, St James's Hospital, Dublin 8, Ireland
Get access Rights & Permissions [Opens in a new window]

Abstract

An elderly patient with bipolar manic-depressive psychosis, stabilised satisfactorily on lithium carbonate, developed acute symptoms of lithium toxicity shortly after commencing mefenamic acid. Vulnerability factors for the interaction may have included age, history of cardiac failure, and impaired glomerular function. It is hypothesised that the interaction may have been mediated by inhibition of prostaglandin activity.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 151 , Issue 6 , December 1987 , pp. 847 - 848
Copyright
Copyright © Royal College of Psychiatrists, 1987 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Calin, A. (1983) In common clinical usage nonsteroidal anti-inflammatory drugs infrequently produce effects on the kidney. American Journal of Kidney Disease, 11, 485–488.CrossRefGoogle Scholar
Gullner, H.-G., Gill, J. R., Barter, F. C. & Dusing, R. (1980) The role of the prostaglandin system in the regulation of renal function in normal women. American Journal of Medicine, 69, 718–724.CrossRefGoogle ScholarPubMed
Henrich, W. L. (1983) Nephrotoxicity of nonsteroidal antiinflammatory agents. American Journal of Kidney Disease, 11, 478–484.CrossRefGoogle Scholar
Reimann, I. W., Dienner, U. & Frolich, J. C. (1983) Indo-methadn but not aspirin increases plasma lithium ion levels. Archives of General Psychiatry, 40, 283–286.CrossRefGoogle ScholarPubMed
Sellars, L. & Wilkinson, R. (1983) Adverse effects of antirheumatic drugs on the kidney. Adverse Drug Reactions and Acute Poisoning Reviews, 2, 51–66.Google Scholar
Yeung Laiwam, A. C. & Mactier, R. A. (1981) Antagonistic effect of nonsteroidal anti-inflammatory drugs on furosemide-induced diuresis in cardiac failure. British Medical Journal, 283, 714.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.