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Lithium Combined with Haloperidol in Schizophrenic Patients

Published online by Cambridge University Press:  02 January 2018

Yaacov Lerner ,
Yaacov Mintzer  and
Miguel Schestatzky
Yaacov Lerner*
Affiliation:
Hadassah Medical School, Hebrew University, and Director, Eitanim Psychiatric Hospital
Yaacov Mintzer
Affiliation:
Eitanim Psychiatric Hospital
Miguel Schestatzky
Affiliation:
Eitanim Psychiatric Hospital, Doar Na'Shimshon, Israel
*
∗Eitanim Government Psychiatric Hospital, Affilitated to the Hebrew University and Hadassah Medical School, Doar-na Shimshon, Israel
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Abstract

Previously, the addition of lithium to haloperidol has been reported to be of modest benefit to schizoaffective patients. To test this treatment on a different sample, 36 mainly schizophrenic patients were subdivided on the basis of the median of their initial depression score on the BPRS into depressive and non-depressive schizophrenic subjects. Each group randomly received haloperidol plus placebo or haloperidol plus lithium for 8 weeks. The schizophrenic patients who were on the depressive side of the median BPRS depression score were found to be the most resistant to neuroleptic treatment alone, and benefited from the addition of lithium.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 153 , Issue 3 , September 1988 , pp. 359 - 362
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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