Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-22T17:45:37.339Z Has data issue: false hasContentIssue false
  • English
  • Français

Lithium Combined with Haloperidol in Schizophrenic Patients

Published online by Cambridge University Press:  02 January 2018

Yaacov Lerner ,
Yaacov Mintzer  and
Miguel Schestatzky
Yaacov Lerner*
Affiliation:
Hadassah Medical School, Hebrew University, and Director, Eitanim Psychiatric Hospital
Yaacov Mintzer
Affiliation:
Eitanim Psychiatric Hospital
Miguel Schestatzky
Affiliation:
Eitanim Psychiatric Hospital, Doar Na'Shimshon, Israel
*
∗Eitanim Government Psychiatric Hospital, Affilitated to the Hebrew University and Hadassah Medical School, Doar-na Shimshon, Israel
Get access Rights & Permissions [Opens in a new window]

Abstract

Previously, the addition of lithium to haloperidol has been reported to be of modest benefit to schizoaffective patients. To test this treatment on a different sample, 36 mainly schizophrenic patients were subdivided on the basis of the median of their initial depression score on the BPRS into depressive and non-depressive schizophrenic subjects. Each group randomly received haloperidol plus placebo or haloperidol plus lithium for 8 weeks. The schizophrenic patients who were on the depressive side of the median BPRS depression score were found to be the most resistant to neuroleptic treatment alone, and benefited from the addition of lithium.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 153 , Issue 3 , September 1988 , pp. 359 - 362
Copyright
Copyright © Royal College of Psychiatrists, 1988 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alexander, P. E., van Kammen, D. P. & Bunney, W. E. (1979) Antipsychotic effects of lithium in schizophrenia. American Journal of Psychiatry, 136, 283–287.Google Scholar
American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM-III). Washington, DC: APA.Google Scholar
Bieoerman, J., Lerner, Y. & Belmaker, R. H. (1979) Combination of lithium carbonate and haloperidol in schizoaffective disorder. Archives of General Psychiatry, 36, 327–333.Google Scholar
Braden, W., Fink, E. B., Qualls, C. B., Christine, K. H. & Samuels, W. O. (1982) Lithium and chlorpromazine in psychotic inpatients. Psychiatry Research, 7, 69–81.Google Scholar
Carman, J. S., Bigelow, L. B. & Wyatt, R. J. (1981) Lithium combined with neuroleptics in chronic schizophrenic and schizo-affective patients. Journal of Clinical Psychiatry, 42, 124–128.Google Scholar
Delva, N. J. & Letemendia, F. J. J. (1982) Lithium treatment in schizophrenia and schizoaffective disorders. British Journal of Psychiatry, 141, 387–400.CrossRefGoogle Scholar
Delva, N. J., Letemendia, F. J. J. & Prowse, A. W. (1981) Lithium withdrawal trial in chronic schizophrenia. British Journal of Psychiatry, 141, 401–406.CrossRefGoogle Scholar
Dixon, W. (1985) BMDP Statistical Software Annual. Berkeley: University of California Press.Google Scholar
Growe, G. A., Crayton, J. W., Klass, D. B., Evans, H. & Strizich, M. (1979) Lithium in chronic schizophrenic. American Journal of Psychiatry, 136, 454–455.Google Scholar
Guy, W., Cleary, P. & Bonato, R. R. (1976) Methodological implications of a large central data system. In ECDEU Assessment Manual. Bethesda, MD: US Department of Health, Education and Welfare, NIMH.Google Scholar
Hamilton, M. (1967) Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology, 6, 278–296.Google Scholar
Lerner, Y. & Moscovich, D. (1985) Depressive symptoms in acute schizophrenic hospitalised patients. Journal of Clinical Psychiatry, 46, 483–484.Google Scholar
Muller, H. J. & Zerssen, D. V. (1981) Depressive states during the clinical treatment of 280 schizophrenic inpatients. Pharmacopsychiatry, 14, 172–179.Google Scholar
Planansky, K. & Johnston, R. (1978) Depressive syndrome in schizophrenia. Acta Psychiatrica Scandinavica, 57, 207–218.Google Scholar
Scheffee, H. A. (1959) The Analysis of Variance. New York: Wiley.Google Scholar
Shalif, I., Lerner, Y. & Dasberg, H. (1981) A symptom profile analysis of antipsychotic drug treatment: non-parametric multidimensional technique. Psychiatry Research, 4, 1–12.Google Scholar
Small, J. G., Kelloms, J. J., Milstein, V. et al (1975) A placebo-controlled study of lithium combined with neuroleptics in chronic schizophrenic patients. American Journal of Psychiatry, 132, 1315–1317.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders (3rd edn). New York: New York State Psychiatric Institute.Google Scholar
Wistedt, B. & Polmsterna, T. (1983) Depressive symptoms in chronic schizophrenic patients after withdrawal of long-acting neuroleptics. Journal of Clinical Psychiatry, 44, 369–371.Google Scholar
Zemlan, F. P., Hirschowitz, J., Sautter, F. J., Hirschowitz, J., Savtter, F. J. & Garver, D. L. (1984) Impact of lithium therapy on core psychotic symptoms of schizophrenia. British Journal of Psychiatry, 144, 64–69.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.