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A Linkage Study of Primary Affective Disorder

Published online by Cambridge University Press:  02 January 2018

Brent Waters*
Affiliation:
Department of Child & Adolescent Psychiatry, Prince of Wales Hospital, New South Wales
Dharmendra Sengar
Affiliation:
Ottawa General Hospital
Irene Marchenko
Affiliation:
Formerly Royal Ottawa Hospital
Yvon Lapierre
Affiliation:
Royal Ottawa Hospital
Cynthia J. Forster-Gibson
Affiliation:
Queen's University, Kingston, Canada
Nancy E. Simpson
Affiliation:
Queen's University, Kingston, Canada
*
Department of Child and Adolescent Psychiatry, Prince of Wales Hospital, High Street, Randwick, New South Wales 2031, Australia

Abstract

Marker loci in 113 members of nine unrelated multiplex families identified by a bipolar proband were tested for linkages with primary affective disorder. Linkage was excluded between the disease locus (assuming that it was a single autosomal dominant gene) and the HLA loci at a recombination fraction of 0.2, the ABO, Rh, and Lu loci at almost 0.05 and the Fy and P loci at 0.001.

Type
Brief Reports
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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References

Campbell, J., Crowe, R. R., Goeken, M., Pfohl, B., Pauls, D. & Palmer, D. (1984) Affective disorder not linked to HLA in a large bipolar kindred. Journal of Affective Disorders, 7, 4551.Google Scholar
Egeland, J. A., Gerhard, D., Pauls, D., Sussex, J., Kidd, K. K., Allen, C., Hostetter, A. & Houseman, D. E. (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature (London), 325, 783787.Google Scholar
Fieve, R. R., Go, R., Dunner, D. L. & Elston, R. (1984) Search for biological/genetic markers in a long-term epidemiological and morbid risk study of affective disorders. Journal of Psychiatric Research, 18, 425445.Google Scholar
Gershon, E. S., Mendlewicz, J., Gastpar, M., Bech, P., Goldin, L. R., Kielholz, R., Rafaelsen, O. J., Vartanian, F. & Bunney, W. E. (1980) A collaborative study of genetic linkage of bipolar manic-depressive illness and red/green colour-blindness. Acta Psychiatrica Scandinavica, 61, 319338.Google Scholar
Goldin, L. R., Cleroet-Darpoux, F. & Gershon, E. S. (1982) Relationship of HLA to major affective disorder not supported. Psychiatry Research, 7, 2945.Google Scholar
Hodge, S. E., Morton, L. A., Tideman, S., Kidd, K. K., Spence, M. A. (1979) Age-of-onset correction available for linkage analysis (LIPED). American Journal of Human Genetics, 31, 761762.Google Scholar
Hodgkinson, S., Sherrington, R., Curling, H., Marchbanks, R., Reeders, S., Mallets, J., McInnes, M., Petursson, H. & Brynjolpsson, J. (1987) Molecular genetic evidence for heterogeneity in manic depression. Nature (London), 325, 805808.Google Scholar
Johnson, G. F. S., Hunt, G. E., Robertson, S. (1981) A linkage study of manic-depressive disorder with HLA antigens, blood groups, serum proteins and red cell enzymes. Journal of Affective Disorders, 3, 4358.Google Scholar
Kidd, K. D., Egeland, J., Moltan, L., Pauls, D. L., Kringer, S. & Messner, K. (1984) Amish study: IV. Genetic linkage study. American Journal of Psychiatry, 14, 10411048.Google Scholar
Kruger, S. D., Turner, W. J. & Kidd, K. K. (1982) The effect of requisite assumptions on linkage analyses of manic–depressive illness with HLA. Biological Psychiatry, 17, 10811099.Google ScholarPubMed
Lamm, L. U. & Olaisen, B. (1985) Report of the committee on the genetic constitution of chromosomes 5 and 6. Human Gene Mapping 8 (1985): Eighth International Workshop on Human Gene Mapping. Cytogenetics and Cell Genetics, 40, 128155.Google Scholar
Mendlewicz, J., Linkowski, P. & Wilmotte, J. (1980) Linkage between ghicose-6 phosphate dehydrogenase deficiency and manic-depressive psychosis. British Journal of Psychiatry, 137, 337342.Google Scholar
Morton, N. E. (1955) Sequential tests for the detection of linkage. American Journal of Human Genetics, 7, 277317.Google Scholar
Nurnberger, J. I. & Gershon, E. S. (1984) Genetics of affective disorders. In Neurobiology of Mood Disorders (eds Post, R. & Ballenger, J.). Baltimore: Williams and Wilkins.Google Scholar
Ott, J. (1974) Estimation of the recombination fraction in human pedigrees: Efficient computation of the likelihood for human linkage studies. American Journal of Human Genetics, 26, 588597.Google Scholar
Robertson, R. (1987) Molecular genetics of the mind. Nature (London), 325, 755.Google Scholar
Smeraldi, E. & Bellodi, L. (1981) Possible linkage between primary affective disorder susceptibility locus and HLA haplotypes. American Journal of Psychiatry, 138, 12321234.Google Scholar
Spitzer, R. L. & Endicott, J. (1977) Schedule for Affective Disorders and Schizophrenia: Life-time Version. New York: Biometrics Research Laboratory.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1977) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders (3rd edn). New York: Biometrics Research Laboratory.Google Scholar
Suarez, B. K. & Croughan, J. (1982) Is the major histocompatibility complex linked to genes that increase susceptibility to affective disorder? A critical appraisal. Psychiatry Research, 7, 1927.Google Scholar
Suarez, B. K. & Reich, T. R. (1984) HLA and major affective disorder. Archives of General Psychiatry, 41, 2227.Google Scholar
Terasaki, P. I., Bernoco, D., Park, M. S., Ozturk, G. & Iwaka, Y. (1978) Microdroplet testing for HLA-A, B, C and D antigens. American Journal of Clinical Pathology, 69, 103120.Google Scholar
Turner, W. J. & King, S. (1983) BPD2: an autosomal dominant form of bipolar affective disorder. Biological Psychiatry, 18, 6388.Google Scholar
Turner, W. J. & King, S. (1981) Two genetically distinct forms of bipolar affective disorder? Biological Psychiatry, 16, 417439.Google Scholar
Weitkamp, L. R., Stancer, H. C., Persad, E., Flood, C. & Guttormsen, S. (1981) Depressive disorders and HLA: a gene on chromosome 6 that can affect behaviour. New England Journal of Medicine, 305, 13011306.Google Scholar
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