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Linkage between Glucose-6-Phosphate Dehydrogenase Deficiency and Manic-Depressive Psychosis

Published online by Cambridge University Press:  29 January 2018

J. Mendlewicz ,
P. Linkowski  and
J. Wilmotte
J. Mendlewicz
Affiliation:
Department of Psychiatry, Erasme Hospital, Free University of Brussels, 808 Route de Lennick, 1070 Brussels, Belgium
P. Linkowski
Affiliation:
Department of Psychiatry, Erasme Hospital, Free University of Brussels, 808 Route de Lennick, 1070 Brussels, Belgium
J. Wilmotte
Affiliation:
Department of Psychiatry, Civil Hospital, Charleroi, and University of Brussels, Belgium
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Summary

Heredity has been shown to be an important factor in the aetiology of manic-depressive psychosis. Recent linkage studies with colour blindness have suggested the presence of an X-linked dominant gene in the transmission of manic-depressive psychosis. We report here positive evidence of a linkage between manic-depressive psychosis and glucose-6-phosphate dehydrogenase deficiency in an informative family assorting for both traits. These results strengthen previous linkage studies in affective illness and support the hypothesis of X-linkage in a subgroup of manic-depressive psychosis.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 137 , Issue 4 , October 1980 , pp. 337 - 342
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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References

Baron, M. (1977) Linkage between an X-chromosome marker (deutan color blindness) and bipolar affective illness. Archives of General Psychiatry, 24, 721–7.Google Scholar
Belmaker, R. H. & Wyatt, R. J. (1976) Possible X-linkage in a family with varied psychoses. Israel Annals of Psychiatry, 14, 345–53.Google Scholar
Edwards, J. H. (1971) The analysis of X-linkage. Annals of Human Genetics, 341, 229–50.Google Scholar
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.Google Scholar
Gall, G. C., Brewer, G. J. & Dern, R. J. (1965) Studies of glucosc-6-phosphate dehydrogenase activity of individual erythrocytes: the methemoglobin elution test for identification of females heterozygous for G6PD deficiency. American Journal of Human Genetics, 17, 359–68.Google Scholar
Mendlewicz, J., Fleiss, J. L. & Fieve, R. R. (1972a) Evidence for X-linkage in the transmission of manic-depressive illness. Journal American Medical Association, 222, 1624–7.Google Scholar
Mendlewicz, J., Fieve, R. R., Rainer, J. D. & Fleiss, J. L. (1972b) Manic-depressive illness: a comparative study of patients with and without a family history. British Journal of Psychiatry, 120, 523–30.Google Scholar
Mendlewicz, J., Fieve, R. R., Rainer, J. D. & Cataldo, M. (1973) Affective disorder on paternal and maternal sides. Observations in bipolar (manic-depressive) patients with and without a family history. British Journal of Psychiatry, 122, 31–4.Google Scholar
Mendlewicz, J. & Fleiss, J. L. (1974) Linkage studies with X-chromosome markers in bipolar (manic-depressive) and unipolar (depressive) illnesses. Biological Psychiatry, 9, 261–94.Google Scholar
Mendlewicz, J. & Rainer, J. D. (1974) Morbidity risk and genetic transmission in manic-depressive illness. American Journal of Human Genetics, 26, 692–701.Google Scholar
Mendlewicz, J., Fleiss, J. L. & Fieve, R. R. (1975a) Linkage studies in affective disorders. The Xg blood group and manic-depressive illness. In: Genetic Research in Psychiatry (Fieve, R. R., Rosenthal, D., Brill, H.). Pp. 219–232. Baltimore-Lonson: The John Hopkins University Press.Google Scholar
Mendlewicz, J., Fleiss, J. L., Cataldo, M. & Rainer, J. D. (1975b) Accuracy of the family history method in family studies in affective illness. Archives of General Psychiatry, 32, 309–14.Google Scholar
Mendlewicz, J. & Rainer, J. D. (1975) Adoption studies supporting genetic transmission of manic-depressive illness. Mature, 268, 327–9.Google Scholar
Ott, J. (1974) Estimation of the recombination fraction in human pedigrees: Efficient computation of the likelihood for human linkage studies. American Journal Human Genetics, 26, 588–97.Google Scholar
Perris, C. (1968) Genetic transmission of depressive psychoses. Acta Psychiatrica Scandinavica, Suppl. 203, 45–52.Google Scholar
Siniscalco, M., Filippi, G. & Latte, B. (1964) Recombination between protan and deutan genes: data on their relative positions in respect of the G6PD locus. Nature, 204, 1062–4.Google Scholar
Slater, E. (1938) Zur Periodik des manisch-depressiven Irreseins. Zeitschrift Gesamte Neurologie und Psychiatrie, 162, 794.Google Scholar
Spitzer, R. L., Endicott, J. & Fleiss, J. L. (1967) Instruments and recording forms for evaluating psychiatric states and history: rational method of development and description. Comprehensive Psychiatry, 8, 321–43.Google Scholar
Winokur, G., Clayton, P. J. & Reich, T. (1969) Manic-Depressive Illness (ed. C. V. Mosby, St Louis).Google Scholar
Zerbin-Rudin, E. (1967) Endogene Psychosen. In: Humangenetik: ein kurzes Handbuch in fünf Bänden. (Becker, P. E.). Pp 446–577. Stuttgart, Georg Thieme-Verlag.Google Scholar
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